VIAL COX, MARIA CECILIAMARIA CECILIAVIAL COXCALDERON GIADROSIC, JUAN FRANCISCOJUAN FRANCISCOCALDERON GIADROSICKLEIN POSTERNACK, ANDRES DAVIDANDRES DAVIDKLEIN POSTERNACK2023-06-062023-06-062021http://hdl.handle.net/11447/4342https://investigadores.udd.cl/handle/123456789/631210.2174/15665240206662007131754262-s2.0-85103608252WOS:000647674200002<jats:sec> <jats:title /> <jats:p>The COVID-19 plague is hitting mankind. Several viruses, including SARS-CoV-1, MERS-CoV, EBOV, and SARS-CoV-2, use the endocytic machinery to enter the cell. Genomic variants in NPC1, which encodes for the endo-lysosomal Niemann-Pick type C1 protein, restricts the host-range of viruses in bats and susceptibility to infections in humans. Lack of NPC1 and its pharmacological suppression inhibits many viral infections including SARS-CoV-1 and Type I Feline Coronavirus Infection. Antiviral effects of NPC1-inhibiting drugs for COVID-19 treatment should be explored.</jats:p> </jats:sec>covid-19sars-cov-2niemann-pick c1modifier genedrug repurposingvirusinfectionantiviral agentscovid-19drug repositioninghumansintracellular signaling peptides and proteinssars-cov-2severity of illness indexvirus internalization1 benzylpiperazine derivativeamphophileangiotensin converting enzyme 2antisense oligonucleotideclomifenediamidehydroxychloroquinenpc intracellular cholesterol transporter 1terconazoleantivirus agentnpc1 protein, humansignal peptideantiviral activityarticlechikungunya viruscholesterol metabolismcoronavirus disease 2019dengue virusdisease severitydrug repositioningebolavirusendocytosisfeline coronavirusfilovirusgene silencinggenetic susceptibilityhepatitis chost rangehumanhuman immunodeficiency viruslysosomelysosome storage diseasemiddle east respiratory syndrome coronavirusmodifier genemultiple sclerosisniemann pick diseasenonhumanplagueprotein functionsevere acute respiratory syndrome coronavirus 2single nucleotide polymorphismvirus entryvirus infectionwest nile viruszika feverzika virusdrug therapypathophysiologyphysiologyseverity of illness indexvirologyvirus entryNPC1 as a Modulator of Disease Severity and Viral Entry of SARSCoV- 2Resource Types::text::journal::journal article