VIAL COX, MARIA CECILIAMARIA CECILIAVIAL COXCALDERON GIADROSIC, JUAN FRANCISCOJUAN FRANCISCOCALDERON GIADROSICKLEIN POSTERNACK, ANDRES DAVIDANDRES DAVIDKLEIN POSTERNACK2023-06-062023-06-062021http://hdl.handle.net/11447/4342https://investigadores.udd.cl/handle/123456789/631210.2174/15665240206662007131754262-s2.0-85103608252WOS:000647674200002<jats:sec> <jats:title /> <jats:p>The COVID-19 plague is hitting mankind. Several viruses, including SARS-CoV-1, MERS-CoV, EBOV, and SARS-CoV-2, use the endocytic machinery to enter the cell. Genomic variants in NPC1, which encodes for the endo-lysosomal Niemann-Pick type C1 protein, restricts the host-range of viruses in bats and susceptibility to infections in humans. Lack of NPC1 and its pharmacological suppression inhibits many viral infections including SARS-CoV-1 and Type I Feline Coronavirus Infection. Antiviral effects of NPC1-inhibiting drugs for COVID-19 treatment should be explored.</jats:p> </jats:sec>NPC1 as a Modulator of Disease Severity and Viral Entry of SARSCoV- 2Resource Types::text::journal::journal article