A liaF Codon Deletion Abolishes Daptomycin Bactericidal Activity against Vancomycin-Resistant Enterococcus faecalis
Journal
Antimicrobial Agents and Chemotherapy
ISSN
0066-4804
1098-6596
Date Issued
2013
Author(s)
Truc T. Tran
Lorena Diaz
Diana Panesso
Jinnethe Reyes
Barbara E. Murray
Cesar A. Arias
Type
Resource Types::text::journal::journal article
URL Institutional Repository
Abstract
The genetic bases for antibiotic tolerance are obscure. Daptomycin (DAP) is a lipopeptide antibiotic with bactericidal activity against enterococci. Using time-kill assays, we provide evidence for the first time that a deletion of isoleucine in position 177 of LiaF, a member of the three-component regulatory system LiaFSR involved in the cell envelope response to antimicrobials, is directly responsible for a DAP-tolerant phenotype and is likely to negatively affect response to DAP therapy.
Subjects
faecium
;
endocarditis
;
infections
;
emergence
;
failure