Here, we develop an historical quantitative approach integrating a novel chemostratigraphic record, data on policy making, and socio-economic trends to evaluate the feedback relationship between environmental injustice and Anthropocene in sacrifice zones. We specifically outlined a case study for the Puchuncavi valley -one of the most emblematic sacrifice zones from Chile-. We verify an ever-growing burden of heavy metals and metalloids over the past five decades paced by the staggering expansion of local industrial activities, which has ultimately been spurred by national and transnational market forces. Local poverty levels have declined concomitantly, but this path towards social equality is marginal as costs of pollution have exacerbated through time. Indeed, national and international pollution control actions appear insufficient in mitigating the cumulative impact brought by highly toxic elements. Thus, our sub-decadal reconstruction for pollution trends over the past 136 years from a sediment record, emerges as a science-based instrument for informing the discussion on Anthropocene governance. Furthermore, it helps to advance in the assessment of environmental inequality in societal models that prioritize economic growth to the detriment of socio-environmental security.