GONZALEZ COFRE, FERNANDO OMAR

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Switching Stable Kidney Transplant Recipients to a Generic Tacrolimus Is Feasible and Safe, but It Must Be Monitored
(2017)
Fernando González
;
Elizabeth Arriagada
;
René López
;
René Carrasco
;
NATALIA BERNARDITA GALLARDO CHAPARRO
<jats:p><jats:italic>Background</jats:italic>. Tacrolimus is the primary immunosuppressive drug used in kidney transplant patients. Replacing brand name products with generics is a controversial issue that we studied after a Chilean Ministry of Health mandate to implement such a switch.<jats:italic>Methods</jats:italic>. Forty-one stable Prograf (Astellas) receiving kidney transplant patients were switched to a generic tacrolimus (Sandoz) in a 1 : 1 dose ratio and were followed up for up to 8 months. All other drugs were maintained as per normal practice.<jats:italic>Results</jats:italic>. Neither tacrolimus doses nor their trough blood levels changed significantly after the switch, but serum creatinine did:<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mn fontstyle="italic">1.62</mml:mn><mml:mo>±</mml:mo><mml:mn fontstyle="italic">0.90</mml:mn></mml:math>versus<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M2"><mml:mn fontstyle="italic">1.75</mml:mn><mml:mo>±</mml:mo><mml:mn fontstyle="italic">0.92</mml:mn></mml:math> mg/dL (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M3"><mml:mi>p</mml:mi><mml:mo><</mml:mo><mml:mn fontstyle="italic">0.001</mml:mn></mml:math>). At the same time, five graft biopsies were performed, and two of them showed cellular acute rejection. There were nine infectious episodes treated satisfactorily with proper therapies. No patient or graft was lost during the follow-up time period.<jats:italic>Conclusion</jats:italic>. Switching from brand name tacrolimus to a generic tacrolimus (Sandoz) is feasible and appears to be safe, but it must be monitored carefully by treating physicians.</jats:p>
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MRI/TRUS fusion vs. systematic biopsy: intra-patient comparison of diagnostic accuracy for prostate cancer using PI-RADS v2
(2020)
Andrés Labra
;
Claudio Silva
;
Fernando González
;
Gerhard Franz
;
Rodrigo Pinochet
8Scopus© Citations 9
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Virtual Unenhanced Images at Dual-Energy CT: Influence on Renal Lesion Characterization
(2019)
Mathias Meyer
;
Rendon C. Nelson
;
Federica Vernuccio
;
GONZALEZ COFRE, FERNANDO OMAR
;
Alfredo E. Farjat
1Scopus© Citations 66
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LI-RADS: Diagnostic Performance of Hepatobiliary Phase Hypointensity and Major Imaging Features of LR-3 and LR-4 Lesions Measuring 10-19 mm With Arterial Phase Hyperenhancement
(2019)
Federica Vernuccio
;
Roberto Cannella
;
Mathias Meyer
;
Kingshuk Roy Choudhoury
;
Fernando Gonzáles
Scopus© Citations 33 1
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Correlation of preoperative imaging characteristics with donor outcomes and operative difficulty in laparoscopic donor nephrectomy
(2020)
Fides R. Schwartz
;
Brian I. Shaw
;
Reginald Lerebours
;
Federica Vernuccio
;
Francesca Rigiroli
Scopus© Citations 6 19
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Comparison of Iodine Quantification and Conventional Attenuation Measurements for Differentiating Small, Truly Enhancing Renal Masses From High-Attenuation Nonenhancing Renal Lesions With Dual-Energy CT
(2019)
Mathias Meyer
;
Rendon C. Nelson
;
Federica Vernuccio
;
GONZALEZ COFRE, FERNANDO OMAR
;
Christoph Schabel
Scopus© Citations 16 1
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Variability of quantitative measurements of metastatic liver lesions: a multi-radiation-dose-level and multi-reader comparison
(2020)
Yuqin Ding
;
Daniele Marin
;
Federica Vernuccio
;
GONZALEZ COFRE, FERNANDO OMAR
;
Hannah V. Williamson
Scopus© Citations 4 3
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Secondary rectal linitis plastica caused by prostatic adenocarcinoma - magnetic resonance imaging findings and dissemination pathways: A case report
(2024)
LABRA WEITZLER, ANDRES ANTONIO
;
SCHIAPPACASSE FAUNDES, GIANCARLO
;
Rolando Alfonso Cocio
;
Jorge Tomás Torres
;
GONZALEZ COFRE, FERNANDO OMAR
<jats:p>BACKGROUND</jats:p> <jats:p>Secondary rectal linitis plastica (RLP) from prostatic adenocarcinoma is a rare and poorly understood form of metastatic spread, characterized by a desmoplastic response and concentric rectal wall infiltration with mucosal preservation. This complicates endoscopic diagnosis and can mimic gastrointestinal malignancies. This case series underscores the critical role of magnetic resonance imaging (MRI) in identifying the distinct imaging features of RLP and highlights the importance of considering this condition in the differential diagnosis of patients with a history of prostate cancer.</jats:p> <jats:p>CASE SUMMARY</jats:p> <jats:p>Three patients with secondary RLP due to prostatic adenocarcinoma presented with varied clinical features. The first patient, a 76-year-old man with advanced prostate cancer, had rectal pain and incontinence. MRI showed diffuse prostatic invasion and significant rectal wall thickening with a characteristic "target sign" pattern. The second, a 57-year-old asymptomatic man with elevated prostate-specific antigen levels and a history of prostate cancer exhibited rectoprostatic angle involvement and rectal wall thickening on MRI, with positron emission tomography/computed tomography PSMA confirming the prostatic origin of the metastatic spread. The third patient, an 80-year-old post-radical prostatectomy, presented with refractory constipation. MRI revealed a neoplastic mass infiltrating the rectal wall. In all cases, MRI consistently showed stratified thickening, concentric signal changes, restricted diffusion, and contrast enhancement, which were essential for diagnosing secondary RLP. Biopsies confirmed the prostatic origin of the neoplastic involvement in the rectum.</jats:p> <jats:p>CONCLUSION</jats:p> <jats:p>Recognizing MRI findings of secondary RLP is essential for accurate diagnosis and management in prostate cancer patients.</jats:p>
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GONZALEZ COFRE, FERNANDO OMAR

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