EFFECTIVENESS AND SAFETY OF THE TETRAVALENT TAK-003 DENGUE VACCINE: A SYSTEMATIC REVIEW

Journal
Medicina (Buenos Aires)
ISSN
00257680
Date Issued
2024-07-01
Author(s)
Bengolea, Agustín
Scigliano, Clara
Ramos-Rojas, Jose T.
Catalano, Hugo N.
Izcovich, Ariel
Type
Resource Types::text::journal::journal article::review article
Scopus ID
2-s2.0-85201999858
WoS ID
WOS:001293434800012, WOS:001293434800013
URL
Abstract
In Argentina, the dengue virus has experienced an increase in recent years. This study aims to conduct a systematic review to evaluate the effectiveness and safety of the TAK-003 tetravalent dengue vaccine in this context. A systematic review of randomized controlled trials comparing the effectiveness and safety of the vaccine with placebo in the general population was conducted. The search was carried out in Epistemonikos, and two researchers independently assessed the studies. Risk of bias was evaluated using the Cochrane Rob 2 tool. A meta-analysis of the results was performed, and the certainty of evidence was assessed using the GRADE methodology. We concluded, with high certainty of evidence, that the tetravalent dengue vaccine reduces severe infections (RR 0.17, 95% CI 0.12 to 0.24) and infections by the dengue virus (RR 0.40, 95% CI 0.36 to 0.45) in a population ≤17 years. The vaccine may not increase the risk of serious adverse events, although it is important to note the low certainty of evidence (RR 1.04, 95% CI: 0.69-1.55). The use of the tetravalent dengue vaccine decreases the risk of severe and non-severe dengue infections in this population. However, there is low certainty of evidence regarding the vaccine’s safety. The decision to vaccinate should consider the magnitude of benefits relative to the risk of infection.
Cite this document
Ramos, J. (2024). Effectiveness and Safety of the Tetravalent Tak-003 dengue vaccine: a systematic review. Medicina 84(4): 689-707
Subjects
Argentina

; 

dengue

; 

GRADE

; 

systematic review

; 

tetravalent vaccine