Routine Ultrasonography Guidance for Femoral Vascular Access for Cardiac Procedures
Journal
JAMA Cardiology
ISSN
2380-6583
Date Issued
2022
Author(s)
Sanjit S. Jolly
Sulaiman AlRashidi
Marc-André d’Entremont
Omar Alansari
Bradley Brochu
Laura Heenan
Elizabeth Skuriat
Jessica Tyrwhitt
Michael Raco
Michael Tsang
Nicholas Valettas
James L. Velianou
Tej Sheth
Matthew Sibbald
Shamir R. Mehta
Natalia Pinilla-Echeverri
Jon David Schwalm
Madhu K. Natarajan
Andrew Kelly
Elie Akl
Sarah Tawadros
Mercedes Camargo
Walaa Faidi
John Bauer
Rachel Moxham
James Nkurunziza
Gustavo Dutra
Type
Resource Types::text::journal::journal article
Abstract
<jats:sec><jats:title>Importance</jats:title><jats:p>A significant limitation of femoral artery access for cardiac interventions is the increased risk of vascular complications and bleeding compared with radial access. Strategies to make femoral access safer are needed.</jats:p></jats:sec><jats:sec><jats:title>Objective</jats:title><jats:p>To determine whether routinely using ultrasonography guidance for femoral arterial access for coronary angiography/intervention reduces bleeding or vascular complications.</jats:p></jats:sec><jats:sec><jats:title>Design, Setting, and Participants</jats:title><jats:p>The Routine Ultrasound Guidance for Vascular Access for Cardiac Procedures (UNIVERSAL) randomized clinical trial is a multicenter, prospective, open-label trial of ultrasonography-guided femoral access vs no ultrasonography for coronary angiography or intervention with planned femoral access. Patients were randomized from June 26, 2018, to April 26, 2022. Patients with ST-elevation myocardial infarction were not eligible.</jats:p></jats:sec><jats:sec><jats:title>Interventions</jats:title><jats:p>Ultrasonography guidance vs no ultrasonography guidance for femoral arterial access on a background of fluoroscopic landmarking.</jats:p></jats:sec><jats:sec><jats:title>Main Outcomes and Measures</jats:title><jats:p>The primary composite outcome is the composite of major bleeding based on the Bleeding Academic Research Consortium 2, 3, or 5 criteria or major vascular complications within 30 days.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>A total of 621 patients were randomized at 2 centers in Canada (mean [SD] age, 71 [10.24] years; 158 [25.4%] female). The primary outcome occurred in 40 of 311 patients (12.9%) in the ultrasonography group vs 50 of 310 patients (16.1%) without ultrasonography (odds ratio, 0.77 [95% CI, 0.49-1.20]; <jats:italic>P</jats:italic> = .25). The rates of Bleeding Academic Research Consortium 2, 3, or 5 bleeding were 10.0% (31 of 311) vs 10.7% (33 of 310) (odds ratio, 0.93 [95% CI, 0.55-1.56]; <jats:italic>P</jats:italic> = .78). The rates of major vascular complications were 6.4% (20 of 311) vs 9.4% (29 of 310) (odds ratio, 0.67 [95% CI, 0.37-1.20]; <jats:italic>P</jats:italic> = .18). Ultrasonography improved first-pass success (277 of 311 [86.6%] vs 222 of 310 [70.0%]; odds ratio, 2.76 [95% CI, 1.85-4.12]; <jats:italic>P</jats:italic> &lt; .001) and reduced the number of arterial puncture attempts (mean [SD], 1.2 [0.5] vs 1.4 [0.8]; mean difference, −0.26 [95% CI, −0.37 to −0.16]; <jats:italic>P</jats:italic> &lt; .001) and venipuncture (10 of 311 [3.1%] vs 37 of 310 [11.7%]; odds ratio, 0.24 [95% CI, 0.12-0.50]; <jats:italic>P</jats:italic> &lt; .001) with similar times to access (mean [SD], 114 [185] vs 129 [206] seconds; mean difference, −15.1 [95% CI, −45.9 to 15.8]; <jats:italic>P</jats:italic> = .34). All prerandomization prespecified subgroups were consistent with the overall finding.</jats:p></jats:sec><jats:sec><jats:title>Conclusions and Relevance</jats:title><jats:p>In this randomized clinical trial, use of ultrasonography for femoral access did not reduce bleeding or vascular complications. However, ultrasonography did reduce the risk of venipuncture and number of attempts. Larger trials may be required to demonstrate additional potential benefits of ultrasonography-guided access.</jats:p></jats:sec><jats:sec><jats:title>Trial Registration</jats:title><jats:p>ClinicalTrials.gov Identifier: <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="https://clinicaltrials.gov/ct2/show/NCT03537118">NCT03537118</jats:ext-link></jats:p></jats:sec>
Subjects
aged
;
coronary angiography
;
female
;
femoral artery
;
fluoroscopy
;
hemorrhage
;
humans
;
male
;
prospective studies
;
radial artery
;
acetylsalicylic acid
;
anticoagulant agent
;
clopidogrel
;
prasugrel
;
ticagrelor
;
warfarin
;
acute coronary syndrome
;
aged
;
artery puncture
;
article
;
atrial fibrillation
;
bleeding
;
blood vessel injury
;
canada
;
cerebrovascular accident
;
clinical outcome
;
confidence interval
;
controlled study
;
coronary angiography
;
female
;
femoral artery
;
fluoroscopy
;
human
;
interventional ultrasonography
;
intravascular ultrasound
;
major clinical study
;
male
;
meta analysis
;
multicenter study
;
odds ratio
;
open study
;
patient selection
;
percutaneous coronary intervention
;
prospective study
;
randomization
;
randomized controlled trial
;
risk reduction
;
single blind procedure
;
vascular access
;
vein puncture
;
adverse event
;
bleeding
;
coronary angiography
;
procedures
;
radial artery