How the Nature of an Alpha-Nucleophile Determines a Brønsted Type-Plot and Its Reaction Pathways. An Experimental Study
Journal
Frontiers in Chemistry
ISSN
2296-2646
Date Issued
2022
Author(s)
Ricardo A. Tapia
Cristian Suárez-Rozas
Type
Resource Types::text::journal::journal article
URL Institutional Repository
Abstract
<jats:p>The reactions between 2-chloro-5-nitro pyrimidine with a serie of α-nucleophile derivatives were kinetically evaluated. The kinetic study was carried out in aqueous media and the data shown an unusual split on the Brønsted type-plot, opening a controversial discussion based on reactivities and possible reaction pathways. These split Brønsted type-plots are discussed over the hypothetical transition state (TS) structures associated to concerted or stepwise mechanisms with emphasis on hydrogen bond interactions between electrophile/nucleophile pair able to determine the reactivities and the plausible reaction routes.</jats:p>
Cite this document
Campodónico, P. R., Tapia, R. A., & Suárez-Rozas, C. (2022). How the nature of an alpha-nucleophile determines a brønsted type-plot and its reaction pathways. An experimental study. Frontiers in Chemistry, 9, 740161. https://doi.org/10.3389/fchem.2021.740161
Dataset(s)
Supplementary Material -How the Nature of an Alpha-Nucleophile Determines a Brønsted Type-Plot and Its Reaction Pathways. An Experimental Study
Subjects
snar reactions
;
mechanisms
;
hydrogen bond interaction
;
reactivity
;
bronsted type-plots