Streamlining the Journey of Research Into Clinical Practice: Making Your Patients and Practice Flourish Optimizing Management and Minimizing Risk of Osteoporotic Vertebral Fractures – Perspectives of the AO Spine KF Trauma and Infection Group Key Opinion Leaders
Journal
Global Spine Journal
ISSN
2192-5682
2192-5690
Date Issued
2024
Author(s)
Andrei F. Joaquim
Sebastian F. Bigdon
Richard Bransford
Harvinder Singh Chhabra
Vishal Kumar
Mohammad El-Sharkawi
Lorin M. Benneker
Brian A. Karamian
Jose A. Canseco
Julian Scherer
Ahmed Abdelazim Hassan
Gregory D. Schroeder
Cumhur F. Öner
Shanmuganathan Rajasekaran
Emiliano Vialle
Rishi M. Kanna
Alexander R. Vaccaro
Jin Tee
Gaston Camino-Willhuber
Charles G. Fisher
Marcel F. Dvorak
Klaus J. Schnake
Type
journal-article
DOI
URL
Abstract
<jats:sec><jats:title>Study Design</jats:title><jats:p> Literature review with clinical recommendations. </jats:p></jats:sec><jats:sec><jats:title>Objective</jats:title><jats:p> To highlight important studies about osteoporotic spinal fractures (OF) that may be integrated into clinical practice based on the assessment of the AO Spine KF Trauma and Infection group key opinion leaders. </jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p> 4 important studies about OF that may affect current clinical practice of spinal surgeons were selected and reviewed with the aim of providing clinical recommendations to streamline the journey of research into clinical practice. Recommendations were graded as strong or conditional following the GRADE methodology. </jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p> 4 studies were selected. Article 1: a validation of the Osteoporotic Fracture (OF)-score to treat OF fractures. Conditional recommendation to incorporate the OF score in the management of fractures to improve clinical results. Article 2: a randomized multicenter study comparing romosozumab/alendronate vs alendronate to decrease the incidence of new vertebral fractures. Strong recommendation that the group receiving romosozumab/alendronate had a decreased risk of new OF when compared with the alendronate only group only. Article 3: a systematic literature review of spinal orthoses in the management of. Conditional recommendation to prescribe a spinal orthosis to decrease pain and improve quality of life. Article 4: post-traumatic deformity after OF. A conditional recommendation that middle column injury and pre-injury use of steroids may lead to high risk of post-traumatic deformity after OF. </jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p> Management of patients with OF is still complex and challenging. This review provides some recommendations that may help surgeons to better manage these patients and improve their clinical practice. </jats:p></jats:sec>