Initial-onset acute and chronic recurrent stages are two distinctive courses of Vogt-Koyanagi-Harada disease
Journal
Journal of Ophthalmic Inflammation and Infection
ISSN
1869-5760
Date Issued
2020
Author(s)
Carl Herbort
Rodrigo A. Valenzuela
Ahmed M. Abu El-Asrar
Lourdes Arellanes-Garcia
Ariel Schlaen
Joyce Yamamoto
Carlos Pavesio
Type
Resource Types::text::journal::journal article
URL Institutional Repository
Abstract
<jats:title>Abstract</jats:title><jats:sec>
<jats:title>Purpose</jats:title>
<jats:p>To describe distinctive stages of Vogt-Koyanagi-Harada (VKH) disease: initial-onset acute versus chronic recurrent disease.</jats:p>
</jats:sec><jats:sec>
<jats:title>Methods</jats:title>
<jats:p>A comprehensive literature review regarding stages and clinical presentations of VKH disease was conducted.</jats:p>
</jats:sec><jats:sec>
<jats:title>Results</jats:title>
<jats:p>Despite a list of signs that has been described as characteristic features of early or late phases of VKH disease, the current classification -developed by an international committee and published in 2001- does not consider a distinction regarding the time from onset of disease symptoms, and specific findings observed at certain time point from the symptoms presentation and outcomes related to the stage of VKH disease. In that sense, chronic recurrent VKH disease is more refractory to treatment and is associated with a higher rate of complications. Accordingly, this subset of VKH patients has poorer functional and anatomical outcomes than patients with an initial-onset acute disease.</jats:p>
</jats:sec><jats:sec>
<jats:title>Conclusions</jats:title>
<jats:p>An early clear distinction of VKH phenotype [Initial-onset acute versus chronic recurrent disease] should be considered in each clinical scenario, evaluating the delay in diagnosis and the clinical presentation, since it may help clinicians to perform a correct disease prognosis categorization and thus to make treatment decisions in terms of potential refractoriness or expected clinical outcomes.</jats:p>
</jats:sec>
<jats:title>Purpose</jats:title>
<jats:p>To describe distinctive stages of Vogt-Koyanagi-Harada (VKH) disease: initial-onset acute versus chronic recurrent disease.</jats:p>
</jats:sec><jats:sec>
<jats:title>Methods</jats:title>
<jats:p>A comprehensive literature review regarding stages and clinical presentations of VKH disease was conducted.</jats:p>
</jats:sec><jats:sec>
<jats:title>Results</jats:title>
<jats:p>Despite a list of signs that has been described as characteristic features of early or late phases of VKH disease, the current classification -developed by an international committee and published in 2001- does not consider a distinction regarding the time from onset of disease symptoms, and specific findings observed at certain time point from the symptoms presentation and outcomes related to the stage of VKH disease. In that sense, chronic recurrent VKH disease is more refractory to treatment and is associated with a higher rate of complications. Accordingly, this subset of VKH patients has poorer functional and anatomical outcomes than patients with an initial-onset acute disease.</jats:p>
</jats:sec><jats:sec>
<jats:title>Conclusions</jats:title>
<jats:p>An early clear distinction of VKH phenotype [Initial-onset acute versus chronic recurrent disease] should be considered in each clinical scenario, evaluating the delay in diagnosis and the clinical presentation, since it may help clinicians to perform a correct disease prognosis categorization and thus to make treatment decisions in terms of potential refractoriness or expected clinical outcomes.</jats:p>
</jats:sec>
Subjects
categorization
;
chronic vkh
;
initial-onset acute vkh
;
vogt-koyanagi-harada disease
;
acute disease
;
chronic disease
;
clinical feature
;
clinical outcome
;
clinical practice
;
disease classification
;
disease course
;
human
;
outcome assessment
;
phenotype
;
priority journal
;
prognosis
;
recurrent disease
;
retina detachment
;
review
;
symptom
;
vogt koyanagi syndrome