Genetic Background Matters: Population-Based Studies in Model Organisms for Translational Research
Journal
International Journal of Molecular Sciences
ISSN
1422-0067
Date Issued
2022
Author(s)
Anyelo Durán
Macarena Las Heras
Juan Carlos Rubilar
Francisco A. Cubillos
Patricio Olguín
Andrés D. Klein
Type
Resource Types::text::journal::journal article
URL Institutional Repository
Abstract
<jats:p>We are all similar but a bit different. These differences are partially due to variations in our genomes and are related to the heterogeneity of symptoms and responses to treatments that patients exhibit. Most animal studies are performed in one single strain with one manipulation. However, due to the lack of variability, therapies are not always reproducible when treatments are translated to humans. Panels of already sequenced organisms are valuable tools for mimicking human phenotypic heterogeneities and gene mapping. This review summarizes the current knowledge of mouse, fly, and yeast panels with insightful applications for translational research.</jats:p>
Cite this document
Olguín, V., Durán, A., Las Heras, M., Rubilar, J. C., Cubillos, F. A., Olguín, P., & Klein, A. D. (2022). Genetic background matters: Population-based studies in model organisms for translational research. International Journal of Molecular Sciences, 23(14), 7570. https://doi.org/10.3390/ijms23147570
Subjects
drosophila
;
gene mapping
;
genetic background
;
mouse
;
precision medicine
;
saccharomyces cerevisiae
;
systems genetics
;
translational research
;
animals
;
chromosome mapping
;
genetic background
;
genome
;
humans
;
mice
;
saccharomyces cerevisiae
;
translational research, biomedical
;
adult
;
animal experiment
;
drosophila
;
gene mapping
;
genetic background
;
human
;
male
;
mouse
;
nonhuman
;
personalized medicine
;
review
;
saccharomyces cerevisiae
;
systems genetics
;
translational research
;
treatment response
;
yeast
;
animal
;
chromosomal mapping
;
genetic background
;
genetics
;
genome