Inhibition of PORCN Blocks Wnt Signaling to Attenuate Progression of Oral Carcinogenesis
Journal
Clinical Cancer Research
ISSN
1078-0432
1557-3265
Date Issued
2023
Author(s)
Daniel Peña-Oyarzún
Tania Flores
Vicente A. Torres
Andrew F.G. Quest
Catalina Kretschmar
Pamela Contreras
Andrea Maturana-Ramírez
Alfredo Criollo
Montserrat Reyes
Type
Resource Types::text::journal::journal article
Abstract
Oral squamous cell carcinoma (OSCC) is commonly preceded by potentially malignant lesions, referred to as oral dysplasia. We recently reported that oral dysplasia is associated with aberrant activation of the Wnt/β-catenin pathway, due to overexpression of Wnt ligands in a Porcupine (PORCN)-dependent manner. Pharmacologic inhibition of PORCN precludes Wnt secretion and has been proposed as a potential therapeutic approach to treat established cancers. Nevertheless, there are no studies that explore the effects of PORCN inhibition at the different stages of oral carcinogenesis.
Cite this document
Peña-Oyarzún, D., Flores, T., Torres, V. A., Quest, A. F. G., Lobos-González, L., Kretschmar, C., Contreras, P., Maturana-Ramírez, A., Criollo, A., & Reyes, M. (2024). Inhibition of porcn blocks wnt signaling to attenuate progression of oral carcinogenesis. Clinical Cancer Research, 30(1), 209-223. https://doi.org/10.1158/1078-0432.CCR-23-0318