Early high-sensitivity troponin elevation in predicting short-term mortality in sepsis: A protocol for a systematic review with meta-analysis
Journal
PLOS ONE
ISSN
1932-6203
Date Issued
2024
Author(s)
Santiago Ferrière-Steinert
Joaquín Valenzuela Jiménez
Sebastián Heskia Araya
Thomas Kouyoumdjian
José Ramos-Rojas
Abraham I. J. Gajardo
Type
journal-article
Abstract
<jats:sec id="sec001">
<jats:title>Background</jats:title>
<jats:p>Sepsis is a common admission diagnosis in the intensive care unit (ICU). The Sepsis-3 consensus associates sepsis diagnosis with acute organ dysfunction. In these patients troponin elevation is a well-established phenomenon, but its clinical significance is not settled, as no systematic review has addressed the prognostic significance of the increasingly prevalent high-sensitivity troponin assays in acute organ dysfunction setting.</jats:p>
<jats:p>This study aims to clarify the association between early serum troponin levels in high-sensitivity assays with short-term mortality risk in septic patients with acute organ dysfunction.</jats:p>
</jats:sec>
<jats:sec id="sec002">
<jats:title>Methods</jats:title>
<jats:p>We will systematically search PubMed, Scopus and Embase for original articles; additionally, a manual search will be carried out through relevant literature. Generally, studies will be deemed eligible for inclusion if they evaluate the association between high-sensitivity troponin in the first 24 hours of admission and ICU, 30-days, or In-hospital mortality; in patients with septic shock or sepsis related to acute organ dysfunction. Two reviewers will independently select studies and extract the data. A meta-analysis for mortality outcome will be performed for comparative data regarding two effect measures: Odd ratios and Standardized Mean differences.</jats:p>
</jats:sec>
<jats:sec id="sec003">
<jats:title>Discussion</jats:title>
<jats:p>This study will provide further evidence about the role of high-sensitivity troponin assays in predicting mortality in septic patients; potentially helping to guide further research and yielding valuable information for patient assessment.</jats:p>
<jats:p>Conclusion about the certainty of evidence will be presented in a ´Summary of findings´ table.</jats:p>
</jats:sec>
<jats:sec id="sec004">
<jats:title>Trial registration</jats:title>
<jats:p>PROSPERO registration:</jats:p>
<jats:p>(<jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42024468883" xlink:type="simple">CRD42024468883</jats:ext-link>).</jats:p>
</jats:sec>
<jats:title>Background</jats:title>
<jats:p>Sepsis is a common admission diagnosis in the intensive care unit (ICU). The Sepsis-3 consensus associates sepsis diagnosis with acute organ dysfunction. In these patients troponin elevation is a well-established phenomenon, but its clinical significance is not settled, as no systematic review has addressed the prognostic significance of the increasingly prevalent high-sensitivity troponin assays in acute organ dysfunction setting.</jats:p>
<jats:p>This study aims to clarify the association between early serum troponin levels in high-sensitivity assays with short-term mortality risk in septic patients with acute organ dysfunction.</jats:p>
</jats:sec>
<jats:sec id="sec002">
<jats:title>Methods</jats:title>
<jats:p>We will systematically search PubMed, Scopus and Embase for original articles; additionally, a manual search will be carried out through relevant literature. Generally, studies will be deemed eligible for inclusion if they evaluate the association between high-sensitivity troponin in the first 24 hours of admission and ICU, 30-days, or In-hospital mortality; in patients with septic shock or sepsis related to acute organ dysfunction. Two reviewers will independently select studies and extract the data. A meta-analysis for mortality outcome will be performed for comparative data regarding two effect measures: Odd ratios and Standardized Mean differences.</jats:p>
</jats:sec>
<jats:sec id="sec003">
<jats:title>Discussion</jats:title>
<jats:p>This study will provide further evidence about the role of high-sensitivity troponin assays in predicting mortality in septic patients; potentially helping to guide further research and yielding valuable information for patient assessment.</jats:p>
<jats:p>Conclusion about the certainty of evidence will be presented in a ´Summary of findings´ table.</jats:p>
</jats:sec>
<jats:sec id="sec004">
<jats:title>Trial registration</jats:title>
<jats:p>PROSPERO registration:</jats:p>
<jats:p>(<jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42024468883" xlink:type="simple">CRD42024468883</jats:ext-link>).</jats:p>
</jats:sec>
Subjects
biomarkers
;
hospital mortality
;
humans
;
intensive care units
;
prognosis
;
sepsis
;
systematic reviews as topic
;
troponin
;
troponin
;
biological marker
;
troponin
;
all cause mortality
;
cohort analysis
;
early high sensitivity troponin elevation
;
human
;
intensive care unit
;
meta analysis
;
multiple organ failure
;
outcome assessment
;
prediction
;
preferred reporting items for systematic reviews and meta-analyses
;
prognostic assessment
;
publication bias
;
review
;
risk assessment
;
sensitivity analysis
;
sepsis
;
short term mortality
;
systematic review
;
blood
;
diagnosis
;
hospital mortality
;
mortality
;
prognosis
;
systematic review (topic)