According to the United Nations, in order to avoid some of the worst outcomes of climate change, the world must achieve net zero carbon emissions by 2050 at the very latest. That is the aim of the Race to Zero Campaign. Since 2019, more than 10,000 organizations around the world have embraced Race to Zero, which has been able to successfully create a relevant, global, and diverse cross-sector partnership, tearing down the barriers that have emerged from uncertainty. Building on three key cross-partnership elements (strategic, institutional, and learning), combined with the uncertainties faced by the partners, we describe the resources and activities that have made that possible.