Plasma versus Erythrocyte Vitamin E in Renal Transplant Recipients, and Duality of Tocopherol Species
Journal
Nutrients
ISSN
2072-6643
Date Issued
2019
Author(s)
Camilo G. Sotomayor
Ramón Rodrigo
António W. Gomes-Neto
Juan Guillermo Gormaz
Robert A. Pol
Isidor Minović
Manfred L. Eggersdorfer
Michel Vos
Ineke J. Riphagen
Martin H. de Borst
Ilja M. Nolte
Stefan P. Berger
Gerjan J. Navis
Stephan J. L. Bakker
Type
Resource Types::text::journal::journal article
URL Institutional Repository
Abstract
<jats:p>Redox imbalance is an adverse on-going phenomenon in renal transplant recipients (RTR). Vitamin E has important antioxidant properties that counterbalance its deleterious effects. However, plasma vitamin E affinity with lipids challenges interpretation of its levels. To test the hypothesis that erythrocyte membranes represent a lipids-independent specimen to estimate vitamin E status, we performed a cross-sectional study in a cohort of adult RTR (n = 113) recruited in a university setting (2015–2018). We compared crude and total lipids-standardized linear regression-derived coefficients of plasma and erythrocyte tocopherol species in relation to clinical and laboratory parameters. Strongly positive associations of fasting lipids with plasma tocopherol became inverse, rather than absent, in total lipids-standardized analyses, indicating potential overadjustment. Whilst, no variables from the lipids domain were associated with the tocopherol species measured from erythrocyte specimens. In relation to inflammatory status and clinical parameters with antioxidant activity, we found associations in directions that are consistent with either beneficial or adverse effects concerning α- or γ-tocopherol, respectively. In conclusion, erythrocytes offer a lipids-independent alternative to estimate vitamin E status and investigate its relationship with parameters over other biological domains. In RTR, α- and γ-tocopherol may serve as biomarkers of relatively lower or higher vulnerability to oxidative stress and inflammation, noticeably in opposite directions.</jats:p>
Subjects
vitamin e
;
alpha-tocopherol
;
gamma-tocopherol
;
erythrocyte
;
inflammation
;
oxidative stress
;
cardiovascular disease
;
renal transplantation
;
renal transplant recipients
;
adult
;
aged
;
alpha-tocopherol
;
biomarkers
;
cross-sectional studies
;
erythrocytes
;
female
;
gamma-tocopherol
;
humans
;
inflammation
;
kidney transplantation
;
lipids
;
male
;
middle aged
;
oxidation-reduction
;
oxidative stress
;
plasma
;
alpha tocopherol
;
antioxidant
;
biological marker
;
c reactive protein
;
cholesterol
;
creatinine
;
gamma tocopherol
;
glucose
;
hemoglobin a1c
;
high density lipoprotein cholesterol
;
lipid
;
low density lipoprotein cholesterol
;
triacylglycerol
;
uric acid
;
alpha tocopherol
;
biological marker
;
gamma tocopherol
;
lipid
;
adult
;
antioxidant activity
;
article
;
clinical article
;
colorimetry
;
cross-sectional study
;
enzymatic assay
;
erythrocyte
;
female
;
follow up
;
graft recipient
;
human
;
immunosuppressive treatment
;
inflammation
;
kidney graft
;
liquid chromatography
;
male
;
nephelometry
;
oxidation reduction reaction
;
spectrophotometry
;
ultraviolet visible spectroscopy
;
urinalysis
;
vitamin blood level
;
adverse event
;
aged
;
blood
;
comparative study
;
erythrocyte
;
inflammation
;
kidney transplantation
;
metabolism
;
middle aged
;
oxidative stress
;
plasma