Lactadherin: From a Well-Known Breast Tumor Marker to a Possible Player in Extracellular Vesicle-Mediated Cancer Progression
Journal
International Journal of Molecular Sciences
ISSN
1422-0067
Date Issued
2022
Author(s)
Eduardo Durán-Jara
Tamara Vera-Tobar
Lorena De Lourdes Lobos-González
Type
Resource Types::text::journal::journal article
URL Institutional Repository
Abstract
<jats:p>Lactadherin is a secreted glycoprotein associated with the milk fat globule membrane, which is highly present in the blood and in the mammary tissue of lactating women. Several biological functions have been associated with this protein, mainly attributable to its immunomodulatory role promoting phagocyte-mediated clearance of apoptotic cells. It has been shown that lactadherin also plays important roles in cell adhesion, the promotion of angiogenesis, and tissue regeneration. On the other hand, this protein has been used as a marker of breast cancer and tumor progression. Recently, high levels of lactadherin has been associated with poor prognosis and decreased survival, not only in breast cancer, but also in melanoma, ovarian, colorectal, and other types of cancer. Although the mechanisms responsible for the tumor-promoting effects attributed to lactadherin have not been fully elucidated, a growing body of literature indicates that lactadherin could be a promising therapeutic target and/or biomarker for breast and other tumors. Moreover, recent studies have shown its presence in extracellular vesicles derived from cancer cell lines and cancer patients, which was associated with cancer aggressiveness and worse prognosis. Thus, this review will focus on the link between lactadherin and cancer development and progression, its possible use as a cancer biomarker and/or therapeutic target, concluding with a possible role of this protein in cellular communication mediated by extracellular vesicles</jats:p>
Cite this document
Durán-Jara, E., Vera-Tobar, T., & Lobos-González, L. D. L. (2022). Lactadherin: From a well-known breast tumor marker to a possible player in extracellular vesicle-mediated cancer progression. International Journal of Molecular Sciences, 23(7), 3855. https://doi.org/10.3390/ijms23073855
Project(s)
Dataset(s)
Dataset - Lactadherin: From a Well-Known Breast Tumor Marker to a Possible Player in Extracellular Vesicle-Mediated Cancer Progression
Subjects
lactadherin
;
breast cancer
;
metastasis
;
extracellular vesicles
;
exosomes
;
antigens, surface
;
biomarkers, tumor
;
breast
;
breast neoplasms
;
extracellular vesicles
;
female
;
humans
;
lactation
;
milk proteins
;
lactadherin
;
tumor marker
;
membrane antigen
;
milk protein
;
tumor marker
;
breast tumor
;
cancer growth
;
carcinogenesis
;
cell communication
;
cell proliferation
;
cell survival
;
epithelial mesenchymal transition
;
exosome
;
human
;
immunomodulation
;
metastatic breast cancer
;
model
;
patent
;
pathophysiology
;
prediction
;
promoter region
;
protein expression
;
protein function
;
review
;
translational medicine
;
tumor cell
;
tumor growth
;
breast
;
female
;
genetics
;
lactation
;
metabolism
;
pathology