Folate and Vitamin B12 Levels in Chilean Women with PCOS and Their Association with Metabolic Outcomes
Journal
Nutrients
ISSN
2072-6643
Date Issued
2024
Author(s)
Matías Carrasco-Cabezas
Taís Silveira Assmann
Leslie Cerpa
Susan Calfunao
Bárbara Echiburú
Manuel Maliqueo
Nicolás Crisosto
Francisca Salas-Pérez
Type
journal-article
Abstract
<jats:p>Polycystic ovary syndrome (PCOS) is a common endocrine disorder that affects women of reproductive age. Many women with PCOS have been found to have an unbalanced diet and deficiencies in essential nutrients. This study aimed to assess the levels of folate and vitamin B12 (B12) and their relationship with metabolic factors in women with PCOS. Anthropometric, clinical, and genetic analyses were conducted to evaluate markers related to one-carbon metabolism in women with PCOS and in a control group. The PCOS group had a higher BMI and HOMA-IR (1.7 vs. 3.1; p < 0.0001). HDL cholesterol levels were 23% lower and triglyceride levels were 74% higher in women with PCOS. Although there were no significant differences in folate and B12 levels between the PCOS and control groups, over 60% of women with PCOS had low B12 levels (<300 pg/mL) and high homocysteine levels. In addition, the MTHFR A1298C and C677T polymorphisms were not associated with PCOS. Moreover, erythrocyte folate levels were positively correlated with fasting glucose, triglycerides, and free androgen index, and negatively correlated with SHBG and LH levels. These results suggest that B vitamins may be associated with the metabolic phenotype in PCOS. This study emphasizes the potential link between folate, vitamin B12, and metabolic and hormonal outcomes in women with PCOS.</jats:p>
Cite this document
Carrasco-Cabezas, M., Assmann, T. S., Martínez, P., Cerpa, L., Calfunao, S., Echiburú, B., Maliqueo, M., Crisosto, N., & Salas-Pérez, F. (2024). Folate and vitamin b12 levels in chilean women with pcos and their association with metabolic outcomes. Nutrients, 16(12), 1937. https://doi.org/10.3390/nu16121937
Subjects
pcos
;
mthfr
;
metabolism
;
polymorphism
;
vitamins