Multidimensional inhibitory signatures of sentential negation in behavioral variant frontotemporal dementia

Journal
Cerebral Cortex
ISSN
1047-3211
1460-2199
Date Issued
2022
Author(s)
Mariano N Díaz-Rivera
Agustina Birba
Sol Fittipaldi
Débora Mola
Yurena Morera
Manuel de Vega
Sebastian Moguilner
Patricia Lillo
Cecilia González Campo
Agustín Ibáñez
Adolfo M García
Type
Resource Types::text::journal::journal article
Scopus ID
2-s2.0-85141770729
WoS ID
WOS:000776252900001
DOI
URL
URL Institutional Repository
Abstract
<jats:title>Abstract</jats:title>
<jats:sec>
<jats:title>Background</jats:title>
<jats:p>Processing of linguistic negation has been associated to inhibitory brain mechanisms. However, no study has tapped this link via multimodal measures in patients with core inhibitory alterations, a critical approach to reveal direct neural correlates and potential disease markers.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Methods</jats:title>
<jats:p>Here we examined oscillatory, neuroanatomical, and functional connectivity signatures of a recently reported Go/No-go negation task in healthy controls and behavioral variant frontotemporal dementia (bvFTD) patients, typified by primary and generalized inhibitory disruptions. To test for specificity, we also recruited persons with Alzheimer's disease (AD), a disease involving frequent but nonprimary inhibitory deficits.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Results</jats:title>
<jats:p>In controls, negative sentences in the No-go condition distinctly involved frontocentral delta (2–3 Hz) suppression, a canonical inhibitory marker. In bvFTD patients, this modulation was selectively abolished and significantly correlated with the volume and functional connectivity of regions supporting inhibition (e.g. precentral gyrus, caudate nucleus, and cerebellum). Such canonical delta suppression was preserved in the AD group and associated with widespread anatomo-functional patterns across non-inhibitory regions.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Discussion</jats:title>
<jats:p>These findings suggest that negation hinges on the integrity and interaction of spatiotemporal inhibitory mechanisms. Moreover, our results reveal potential neurocognitive markers of bvFTD, opening a new agenda at the crossing of cognitive neuroscience and behavioral neurology.</jats:p>
</jats:sec>
Dataset(s)
Subjects
behavioral variant frontotemporal dementia

; 

eeg oscillations

; 

inhibition

; 

multimodal imaging

; 

negation

; 

alzheimer disease

; 

brain

; 

brain mapping

; 

frontotemporal dementia

; 

humans

; 

inhibition, psychological

; 

magnetic resonance imaging

; 

neuropsychological tests

; 

aged

; 

alzheimer disease

; 

angular gyrus

; 

article

; 

brain size

; 

caudate nucleus

; 

cerebellum

; 

cerebellum vermis

; 

cingulum (brain)

; 

clinical article

; 

commission error

; 

controlled study

; 

electroencephalogram

; 

female

; 

forced choice method

; 

frontal variant frontotemporal dementia

; 

functional connectivity

; 

functional magnetic resonance imaging

; 

functional neuroimaging

; 

fusiform gyrus

; 

go no go task

; 

gray matter volume

; 

human

; 

image processing

; 

male

; 

medial frontal cortex

; 

montreal cognitive assessment

; 

multimodal imaging

; 

neuroanatomy

; 

occipital cortex

; 

olfactory cortex

; 

omission error

; 

orbital cortex

; 

oscillation

; 

oscillatory potential

; 

posterior cingulate

; 

primary motor cortex

; 

signal processing

; 

superior frontal gyrus

; 

supplementary motor area

; 

temporal cortex

; 

alzheimer disease

; 

brain

; 

brain mapping

; 

diagnostic imaging

; 

frontotemporal dementia

; 

neuropsychological test

; 

nuclear magnetic resonance imaging