Pathological axis fracture secondary to a solitary bone plasmacytoma: Two cases and a literature review
Journal
Surgical Neurology International
ISSN
2152-7806
Date Issued
2021
Author(s)
Matias Delgado
Marilaura Nuñez
Juan Lopez
Bartolome Marre
Type
Resource Types::text::journal::journal article
URL Institutional Repository
Abstract
<jats:sec id="st1">
<jats:title>Background: </jats:title>
<jats:p>Solitay bone plasmocytoma (SBP) account for just 5–10% of all plasma cell neoplasms. They are infrequent in the cervical spine, especially involving the C0–C2 segment. In this article we conducted a literature review and present the diagnosis, management and long term course of two patients with SBP of C2 causing cervical instability.</jats:p>
</jats:sec>
<jats:sec id="st2">
<jats:title>Methods: </jats:title>
<jats:p>We assessed the clinical records of two patients with SBP in C2 and cervical instability attributed to SP-B involving C2. Both patients presented with progressive, severe cervicalgia, and the “sensation” of skull instability. Magnetic resonance imaging revealed an extensive, infiltrative lesion involving C2 vertebral body and lateral masses, consistent with a plasmacytoma.</jats:p>
</jats:sec>
<jats:sec id="st3">
<jats:title>Results: </jats:title>
<jats:p>Both patients underwent emergency posterior surgical stabilization with craniocervical fixation; this was accompanied by a C2 transpedicular biopsy. Postoperatively, patients exhibited no focal neurological deficits and rapidly became pain free. They additional recieved 25 sessions of local conventional radiation therapy. Both patients are doing well as respective 2 and 7-year follow-up.</jats:p>
</jats:sec>
<jats:sec id="st4">
<jats:title>Conclusion: </jats:title>
<jats:p>Although rare, unstable SBP may present atypical cervical location that readily responds to surgical descompression/fusion and radiotherapy.</jats:p>
</jats:sec>
<jats:title>Background: </jats:title>
<jats:p>Solitay bone plasmocytoma (SBP) account for just 5–10% of all plasma cell neoplasms. They are infrequent in the cervical spine, especially involving the C0–C2 segment. In this article we conducted a literature review and present the diagnosis, management and long term course of two patients with SBP of C2 causing cervical instability.</jats:p>
</jats:sec>
<jats:sec id="st2">
<jats:title>Methods: </jats:title>
<jats:p>We assessed the clinical records of two patients with SBP in C2 and cervical instability attributed to SP-B involving C2. Both patients presented with progressive, severe cervicalgia, and the “sensation” of skull instability. Magnetic resonance imaging revealed an extensive, infiltrative lesion involving C2 vertebral body and lateral masses, consistent with a plasmacytoma.</jats:p>
</jats:sec>
<jats:sec id="st3">
<jats:title>Results: </jats:title>
<jats:p>Both patients underwent emergency posterior surgical stabilization with craniocervical fixation; this was accompanied by a C2 transpedicular biopsy. Postoperatively, patients exhibited no focal neurological deficits and rapidly became pain free. They additional recieved 25 sessions of local conventional radiation therapy. Both patients are doing well as respective 2 and 7-year follow-up.</jats:p>
</jats:sec>
<jats:sec id="st4">
<jats:title>Conclusion: </jats:title>
<jats:p>Although rare, unstable SBP may present atypical cervical location that readily responds to surgical descompression/fusion and radiotherapy.</jats:p>
</jats:sec>
Subjects
bone cyst
;
cervical vertebrae
;
multiple myeloma
;
solitary plasmacytoma
;
bence jones protein
;
adult
;
aged
;
autograft
;
bone biopsy
;
bone graft
;
bone scintiscanning
;
bone tumor
;
cancer radiotherapy
;
case report
;
clinical article
;
disease course
;
electrophoresis
;
emergency surgery
;
female
;
histopathology
;
human
;
hypermetabolism
;
immunohistochemistry
;
middle aged
;
myelography
;
neck pain
;
neuroimaging
;
neuromonitoring
;
neuronavigation
;
nuclear magnetic resonance imaging
;
odontoid process
;
odontoid process fracture
;
pain severity
;
pathologic fracture
;
plasmacytoma
;
positron emission tomography
;
priority journal
;
protein electrophoresis
;
review
;
solitary bone plasmacytoma
;
tumor diagnosis
;
vertebra body
;
x-ray computed tomography