Electrospun Poly(acrylic acid-co-4-styrene sulfonate) as Potential Drug-Eluting Scaffolds for Targeted Chemotherapeutic Delivery Systems on Gastric (AGS) and Breast (MDA-Mb-231) Cancer Cell Lines
Journal
Nanomaterials
ISSN
2079-4991
Date Issued
2022
Author(s)
Andrónico Neira-Carrillo
Ignacio A. Zárate
Eddie Nieto
Nicole Butto-Miranda
Lorena Lobos-González
Matias Del Campo-Smith
Daniel A. Palacio
Bruno F. Urbano
Type
Resource Types::text::journal::journal article
URL Institutional Repository
Abstract
<jats:p>Potential drug-eluting scaffolds of electrospun poly(acrylic acid-co-styrene sulfonate) P(AA-co-SS) in clonogenic assays using tumorigenic gastric and ovarian cancer cells were tested in vitro. Electrospun polymer nanofiber (EPnF) meshes of PAA and PSSNa homo- and P(AA-co-SS) copolymer composed of 30:70, 50:50, 70:30 acrylic acid (AA) and sodium 4-styrene sulfonate (SSNa) units were performed by electrospinning (ES). The synthesis, structural and morphological characterization of all EPnF meshes were analyzed by optical and electron microscopy (SEM-EDS), infrared spectroscopy (FTIR), contact angle, and X-ray diffraction (XRD) measurements. This study shows that different ratio of AA and SSNa of monomers in P(AA-co-SS) EPnF play a crucial role in clonogenic in vitro assays. We found that 50:50 P(AA-co-SS) EPnF mesh loaded with antineoplastic drugs can be an excellent suppressor of growth-independent anchored capacities in vitro assays and a good subcutaneous drug delivery system for chemotherapeutic medication in vivo model for surgical resection procedures in cancer research.</jats:p>
Cite this document
Neira-Carrillo, A., Zárate, I. A., Nieto, E., Butto-Miranda, N., Lobos-González, L., Del Campo-Smith, M., Palacio, D. A., & Urbano, B. F. (2022). Electrospun poly(Acrylic acid-co-4-styrene sulfonate) as potential drug-eluting scaffolds for targeted chemotherapeutic delivery systems on gastric (Ags) and breast (MDA-Mb-231) cancer cell lines. Nanomaterials, 12(21), 3903. https://doi.org/10.3390/nano12213903
Subjects
clonogenic assay
;
electrospinning
;
electrospun fibers
;
gastric and breast cancer cells
;
poly(acrylic acid-co-styrene sulfonate)
;
polymers