Iron-Reduced Graphene Oxide Core–Shell Micromotors Designed for Magnetic Guidance and Photothermal Therapy under Second Near-Infrared Light
Journal
Pharmaceutics
ISSN
1999-4923
Date Issued
2024
Author(s)
Orlando Donoso-González
Ana L. Riveros
José F. Marco
Diego Venegas-Yazigi
Verónica Paredes-García
Camila F. Olguín
Cristina Mayorga-Lobos
Felipe Franco-Campos
Joseph Wang
Marcelo J. Kogan
Soledad Bollo
Daniela F. Báez
Claudia Yañez
University of Chile
Type
journal-article
Abstract
<jats:p>Core–shell micro/nanomotors have garnered significant interest in biomedicine owing to their versatile task-performing capabilities. However, their effectiveness for photothermal therapy (PTT) still faces challenges because of their poor tumor accumulation, lower light-to-heat conversion, and due to the limited penetration of near-infrared (NIR) light. In this study, we present a novel core–shell micromotor that combines magnetic and photothermal properties. It is synthesized via the template-assisted electrodeposition of iron (Fe) and reduced graphene oxide (rGO) on a microtubular pore-shaped membrane. The resulting Fe-rGO micromotor consists of a core of oval-shaped zero-valent iron nanoparticles with large magnetization. At the same time, the outer layer has a uniform reduced graphene oxide (rGO) topography. Combined, these Fe-rGO core–shell micromotors respond to magnetic forces and near-infrared (NIR) light (1064 nm), achieving a remarkable photothermal conversion efficiency of 78% at a concentration of 434 µg mL−1. They can also carry doxorubicin (DOX) and rapidly release it upon NIR irradiation. Additionally, preliminary results regarding the biocompatibility of these micromotors through in vitro tests on a 3D breast cancer model demonstrate low cytotoxicity and strong accumulation. These promising results suggest that such Fe-rGO core–shell micromotors could hold great potential for combined photothermal therapy.</jats:p>
Cite this document
Donoso-González, O., Riveros, A. L., Marco, J. F., Venegas-Yazigi, D., Paredes-García, V., Olguín, C. F., Mayorga-Lobos, C., Lobos-González, L., Franco-Campos, F., Wang, J., Kogan, M. J., Bollo, S., Yañez, C., & Báez, D. F. (2024). Iron-reduced graphene oxide core–shell micromotors designed for magnetic guidance and photothermal therapy under second near-infrared light. Pharmaceutics, 16(7), 856. https://doi.org/10.3390/pharmaceutics16070856
Subjects
cancer
;
core–shell micromotors
;
magnetic guidance
;
photothermal effect
;
photothermal therapy
;
reduced graphene oxide