Metastatic pulmonary calcification: High-resolution computed tomography findings in 23 cases [Calcificação pulmonar metastática: Achados na tomografia computadorizada de alta resolução de 23 casos]

Luciana Camara Belém; Carolina A. Souza; Arthur Soares Souza Jr.; Dante Luiz Escuissato; Bruno Hochhegger; Luiz Felipe Nobre; Rosana Souza Rodrigues; Antônio Carlos Portugal Gomes; CLAUDIO SERGIO SILVA FUENTE ALBA; Marcos Duarte Guimarães; Gláucia Zanetti; Edson Marchiori

doi:10.1590/0100-3984.2016-0123

Metastatic pulmonary calcification: High-resolution computed tomography findings in 23 cases [Calcificação pulmonar metastática: Achados na tomografia computadorizada de alta resolução de 23 casos]

Journal

Radiologia Brasileira

ISSN

1678-7099

0100-3984

Date Issued

2017

Author(s)

Luciana Camara Belém

Carolina A. Souza

Arthur Soares Souza Jr.

Dante Luiz Escuissato

Bruno Hochhegger

Luiz Felipe Nobre

Rosana Souza Rodrigues

Antônio Carlos Portugal Gomes

CLAUDIO SERGIO SILVA FUENTE ALBA

Facultad de Medicina Clínica Alemana Universidad del Desarrollo

Marcos Duarte Guimarães

Gláucia Zanetti

Edson Marchiori

Type

Resource Types::text::journal::journal article

Scopus ID

2-s2.0-85029945802

DOI

10.1590/0100-3984.2016-0123

URL

https://investigadores.udd.cl/handle/123456789/2765

URL Institutional Repository

http://hdl.handle.net/11447/1930

Abstract

Abstract Objective: The aim of this study was to evaluate the high-resolution computed tomography (HRCT) findings in patients diagnosed with metastatic pulmonary calcification (MPC). Materials and Methods: We retrospectively reviewed the HRCT findings from 23 cases of MPC [14 men, 9 women; mean age, 54.3 (range, 26-89) years]. The patients were examined between 2000 and 2014 in nine tertiary hospitals in Brazil, Chile, and Canada. Diagnoses were established by histopathologic study in 18 patients and clinical-radiological correlation in 5 patients. Two chest radiologists analyzed the images and reached decisions by consensus. Results: The predominant HRCT findings were centrilobular ground-glass nodules (n = 14; 60.9%), consolidation with high attenuation (n = 10; 43.5%), small dense nodules (n = 9; 39.1%), peripheral reticular opacities associated with small calcified nodules (n = 5; 21.7%), and ground-glass opacities without centrilobular ground-glass nodular opacity (n = 5; 21.7%). Vascular calcification within the chest wall was found in four cases and pleural effusion was observed in five cases. The abnormalities were bilateral in 21 cases. Conclusion: MPC manifested with three main patterns on HRCT, most commonly centrilobular ground-glass nodules, often containing calcifications, followed by dense consolidation and small solid nodules, most of which were calcified. We also described another pattern of peripheral reticular opacities associated with small calcified nodules. These findings should suggest the diagnosis of MPC in the setting of hypercalcemia.