Plasticity of cardiovascular chemoreflexes after prolonged unilateral carotid body denervation: implications for its therapeutic use
Journal
American Journal of Physiology-Heart and Circulatory Physiology
ISSN
0363-6135
1522-1539
Date Issued
2020
Author(s)
Jaime Eugenín
Carolina Larraín
Patricio Zapata
Type
Resource Types::text::journal::journal article
URL Institutional Repository
Abstract
<jats:p>Unilateral carotid body denervation has been proposed as treatment for sympathetic hyperactivity-related human disorders. Its therapeutic effectiveness for maintaining a persistent decrease in the sympathetic outflow activity will depend on the absence of compensatory chemoreflex plasticity in the remnant carotid and aortic afferents. Here, we suggest that the integrity of central afferents after carotid body denervation is essential to prevent the emergence of plastic functional changes on the contralateral “intact” carotid nerve.</jats:p>
Cite this document
Eugenín, J., Larraín, C., & Zapata, P. (2020). Plasticity of cardiovascular chemoreflexes after prolonged unilateral carotid body denervation: Implications for its therapeutic use. American Journal of Physiology-Heart and Circulatory Physiology, 318(5), H1325-H1336. https://doi.org/10.1152/ajpheart.00451.2019
Subjects
arterial pressure control
;
cardiovascular chemoreflexes
;
carotid body denervation
;
heart rate control
;
petrosal ganglionectomy
;
animals
;
arterial pressure
;
carotid body
;
cats
;
denervation
;
geniculate ganglion
;
reflex
;
sodium cyanide
;
sodium cyanide
;
sodium cyanide
;
adult
;
animal experiment
;
aortic nerve
;
arterial pressure
;
article
;
cardiovascular chemoreflex
;
cardiovascular reflex
;
carotid body
;
carotid sinus nerve
;
chemoreceptor reflex
;
controlled study
;
denervation
;
female
;
ganglion
;
ganglionectomy
;
male
;
nerve cell plasticity
;
neurectomy
;
nonhuman
;
priority journal
;
sensory nerve cell
;
solitary tract nucleus
;
animal
;
arterial pressure
;
carotid body
;
cat
;
denervation
;
drug effect
;
geniculate ganglion
;
physiology
;
reflex
;
surgery