EV-miRNA-Mediated Intercellular Communication in the Breast Tumor Microenvironment
Journal
International Journal of Molecular Sciences
ISSN
1422-0067
Date Issued
2023
Author(s)
Francisca Sepúlveda
Cristina Mayorga-Lobos
Kevin Guzmán
Eduardo Durán-Jara
Lorena Lobos-González
Type
Resource Types::text::journal::journal article
URL Institutional Repository
Abstract
<jats:p>Cancer research has prioritized the study of the tumor microenvironment (TME) as a crucial area of investigation. Understanding the communication between tumor cells and the various cell types within the TME has become a focal point. Bidirectional communication processes between these cells support cellular transformation, as well as the survival, invasion, and metastatic dissemination of tumor cells. Extracellular vesicles are lipid bilayer structures secreted by cells that emerge as important mediators of this cell-to-cell communication. EVs transfer their molecular cargo, including proteins and nucleic acids, and particularly microRNAs, which play critical roles in intercellular communication. Tumor-derived EVs, for example, can promote angiogenesis and enhance endothelial permeability by delivering specific miRNAs. Moreover, adipocytes, a significant component of the breast stroma, exhibit high EV secretory activity, which can then modulate metabolic processes, promoting the growth, proliferation, and migration of tumor cells. Comprehensive studies investigating the involvement of EVs and their miRNA cargo in the TME, as well as their underlying mechanisms driving tumoral capacities, are necessary for a deeper understanding of these complex interactions. Such knowledge holds promise for the development of novel diagnostic and therapeutic strategies in cancer treatment.</jats:p>
Cite this document
Sepúlveda, F., Mayorga-Lobos, C., Guzmán, K., Durán-Jara, E., & Lobos-González, L. (2023). Ev-mirna-mediated intercellular communication in the breast tumor microenvironment. International Journal of Molecular Sciences, 24(17), 13085. https://doi.org/10.3390/ijms241713085
Subjects
cancer progression
;
extracellular vesicles
;
metastasis
;
mirnas
;
small evs
;
tumor progression
;
microrna
;
adipocyte
;
angiogenesis
;
blood vessel permeability
;
breast cancer
;
cancer associated fibroblast
;
cancer growth
;
cell membrane permeability
;
cellular secretion
;
endothelium cell
;
epithelial mesenchymal transition
;
exosome
;
gene targeting
;
human
;
intercellular signaling
;
nonhuman
;
review
;
tumor cell
;
tumor microenvironment