WEITZEL, THOMAS
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WEITZEL, THOMAS
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thomas.weitzel@gmail.com
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14007561700

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Evaluation of Eight Serological Tests for Diagnosis of Imported Schistosomiasis

2012 , Hans-Friedemann Kinkel , Sabine Dittrich , Britta Bäumer , WEITZEL, THOMAS

ABSTRACT The diagnosis of schistosomiasis in individuals from countries where the disease is not endemic is challenging, and few data are available on the accuracy of serological diagnosis in those patients. We evaluated the performance of eight serological assays, including four commercial kits, in the diagnosis of imported schistosomiasis in individuals from areas where the disease is not endemic, including six enzyme-linked immunosorbent assays using three different antigens, an indirect hemagglutination assay, and an indirect immunofluorescent-antibody test. To analyze the assays, we used a total of 141 serum samples, with 121 derived from patients with various parasitic infections (among which were 37 cases of schistosomiasis) and 20 taken from healthy volunteers. The sensitivity values for detection of schistosomiasis cases ranged from 41% to 78% and were higher for Schistosoma mansoni than for S. haematobium infections. Specificity values ranged from 76% to 100%; false-positive results were most frequent for samples from patients with cestode infections. By combining two or more tests, sensitivity improved markedly and specificity decreased only moderately. Serological tests are useful instruments for diagnosing imported schistosomiasis in countries where the disease is not endemic, but due to limitations in test sensitivities, we recommend the use of two or more assays in parallel.

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Reiseimpfungen – Hinweise und Empfehlungen

2022 , Camilla Rothe , Deike Rosenbusch , Martin Alberer , Silja Bühler , Gerd Burchard , Torsten Feldt , Martin P. Grobusch , Annette Kapaun , Carsten Köhler , Christina Kreuzberg , Evelyn Kusi , Micha Löbermann , Karin Meischner , Wolfram Metzger , Andreas Müller , HansNothdurft Dieter , Michael Ramharter , Burkhard Rieke , Clara Schlaich , Christian Schönfeld , Marco H. Schulze , Jörg Siedenburg , Florian Steiner , Olivia Veit , WEITZEL, THOMAS , Gerhard Boecken

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Empfehlungen zur Malariaprophylaxe

2024 , Camilla Rothe , Olivia Veit , Deike Rosenbusch , Silja Bühler , Torsten Feldt , Markus Frühwein , Martin P. Grobusch , Sabine Jordan , Annette Kapaun , Carsten Köhler , Christina Kreuzberg , Micha Löbermann , Karin Meischner , Andreas Müller , Michael Ramharter , Burkhard Rieke , Clara Schlaich , Victoria Schoeller , Christian Schönfeld , Jörg Siedenburg , Günther Slesak , Florian Steiner , WEITZEL, THOMAS , Gerhard Boecken

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International mass gatherings and travel-associated illness: A GeoSentinel cross-sectional, observational study

2019 , Philippe Gautret , Kristina M. Angelo , Hilmir Asgeirsson , Alexandre Duvignaud , Perry J.J. van Genderen , Emmanuel Bottieau , Lin H. Chen , Salim Parker , Bradley A. Connor , Elizabeth D. Barnett , Michael Libman , Davidson H. Hamer , WEITZEL, THOMAS

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Diagnosis and therapy of cutaneous and mucocutaneous Leishmaniasis in Germany

2011 , Gerhard Boecken , Cord Sunderkötter , Christian Bogdan , WEITZEL, THOMAS , Marcellus Fischer , Andreas Müller , Micha Löbermann , Gerlind Anders , Esther von Stebut , Mirjam Schunk , Gerd Burchard , Martin Grobusch , Ralf Bialek , Gundel Harms‐Zwingenberger , Bernhard Fleischer , Mathias Pietras , Michael Faulde , Kay Erkens

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Head-to-head comparison of CAMPYAIR aerobic culture medium versus standard microaerophilic culture for Campylobacter isolation from clinical samples

2023 , Arturo Levican , Carmen Varela , Lorena Porte , WEITZEL, THOMAS , Isabel Briceño , Francisco Guerra , Benjamín Mena , Arthur Hinton

Campylobacter spp. are considered the most frequent cause of acute gastroenteritis worldwide. However, outside high-income countries, its burden is poorly understood. Limited published data suggest that Campylobacter prevalence in low- and middle-income countries is high, but their reservoirs and age distribution are different. Culturing Campylobacter is expensive due to laboratory equipment and supplies needed to grow the bacterium (e.g., selective culture media, microaerophilic atmosphere, and a 42°C incubator). These requirements limit the diagnostic capacity of clinical laboratories in many resource-poor regions, leading to significant underdiagnosis and underreporting of isolation of the pathogen. CAMPYAIR, a newly developed selective differential medium, permits Campylobacter isolation without the need for microaerophilic incubation. The medium is supplemented with antibiotics to allow Campylobacter isolation in complex matrices such as human feces. The present study aims to evaluate the ability of the medium to recover Campylobacter from routine clinical samples. A total of 191 human stool samples were used to compare the ability of CAMPYAIR (aerobic incubation) and a commercial Campylobacter medium (CASA, microaerophilic incubation) to recover Campylobacter. All Campylobacter isolates were then identified by MALDI-TOF MS. CAMPYAIR showed sensitivity and specificity values of 87.5% (95% CI 47.4%–99.7%) and 100% (95% CI 98%–100%), respectively. The positive predictive value of CAMPYAIR was 100% and its negative predictive value was 99.5% (95% CI 96.7%–99.9%); Kappa Cohen coefficient was 0.93 (95% CI 0.79–1.0). The high diagnostic performance and low technical requirements of the CAMPYAIR medium could permit Campylobacter culture in countries with limited resources.

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Dataset - Genomic analysis of the diversity, antimicrobial resistance and virulence potential of Campylobacter jejuni and Campylobacter coli strains from a private health care center in Central Chile

2020 , WEITZEL, THOMAS

This dataset includes bacterial draft genome sequence reannotations of 69 C. jejuni and 12 C. coli strains, the fasta file containing the nucleotide sequence of Campylobacter pathogenicity genes screened for the virulome analysis and the fasta file for the in-house database for plasmid screening analysis in Campylobacter genomes.

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A 4-year-old Girl from Bolivia with a Dark Nodule on Her Toe: Tungiasis

2015 , WEITZEL, THOMAS

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Effect of textile colour on vector mosquito host selection: a simulated field study in Mali, West Africa

2024 , Ursula Benz , Mohamad M Traore , Edita E Revay , Amadou S Traore , Alexey M Prozorov , Issa Traoré , Amy Junnila , Liwang Cui , Aidas Saldaitis , Aboubakr S Kone , Roman V Yakovlev , Younoussa Ziguime , Petrányi Gergely , Siriman Samake , Alou Keita , Günter C Müller , WEITZEL, THOMAS , Camilla Rothe

Abstract Background The effect of clothing colour on the biting rates of different vector mosquito species is not well understood. Studies under tropical field conditions are lacking. This study aimed to determine the influence of clothing colours on mosquito biting rates in rural and suburban settings in West Africa. Methods We performed a simulated field study in a suburban and a rural site in Mali using Mosquito-Magnet traps utilizing CO2 and other attractants, which were covered with black, white, and black/white striped textile sheets covers. These targets operated continuously for 10 consecutive days with bright nights (around full moon) and 10 consecutive days with dark nights (around new moon). Trapped mosquitoes were collected and catch rates counted hourly. Mosquitoes were morphologically identified to the species complex level (Anopheles gambiae s.l. and Culex pipiens s.l.) or species level (Aedes aegypti). A subset of Anopheles specimens were further identified by molecular methods. Results Under bright-night conditions, An. gambiae s.l. was significantly more attracted to black targets than to white and striped targets; during dark nights, no target preference was noted. During bright nights, Cx. pipiens s.l. was significantly more attracted to black and striped targets than to white targets; a similar trend was noted during dark nights (not significant). For day-active Ae. aegypti, striped targets were more attractive than the other targets and black were more attractive than white targets. Conclusions The study firstly demonstrated that under field conditions in Mali, West Africa, mosquito catch rates were influenced by different clothing colours, depending on mosquito species and light conditions. Overall, light colours were least attractive to host-seeking mosquitoes. Using white or other light-coloured clothing can potentially reduce bite exposure and risk of disease transmission in endemic tropical regions.

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Microsporidiosis

2017 , WEITZEL, THOMAS

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