CONGET MOLINA, PAULETTE ANDREA
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CONGET MOLINA, PAULETTE ANDREA
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pconget@udd.cl
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Scopus Author ID
6603343014

Research Output

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Mild hypothermia attenuates lung edema and plasma interleukin-1β in a rat mechanical ventilation-induced lung injury model

2011 , Cruces, Pablo , Ronco, Ricardo , Benjamín Erranz , CONGET MOLINA, PAULETTE ANDREA , CARVAJAL BENAVIDES, CÉSAR CRISTÓBAL , Alejandro Donoso , Franco Díaz

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Intraarticular Administration of Dexamethasone after Mesenchymal Stem Cells Implantation Does Not Improve Significantly the Treatment of Preestablished Full-Thickness Chondral Defect in a Rabbit Model

2013 , Maximiliano Espinosa , Alex Vaisman , Nicolas Nazal , FIGUEROA POBLETE, DAVID HUMBERTO , Marcela Gallegos , CONGET MOLINA, PAULETTE ANDREA

Objective: The aim of this study was to evaluate the contribution to hyaline cartilage regeneration of dexamethasone intraarticular administration after autologous mesenchymal stem cells (MSCs) implantation into a preestablished knee full-thickness chondral defect. Design: Full-thickness chondral defects of 4.5 × 4.5 mm2 were surgically made in both medial femoral condyles of adult male New Zealand rabbits. Two weeks later, autologous ex vivo expanded bone marrow–derived MSCs were embedded in hyaluronic acid and implanted into the chondral defects. Immediately and every week after the intervention, dexamethasone 0.25 mg/kg was intraarticularly administered (MSC/dexa-treated group). Six weeks after MSC transplantation, the animals were euthanized and condyles were characterized molecularly according to aggrecan, collagen type II, and collagen type I gene expression (quantitative reverse transcriptase-polymerase chain reaction) and histologically (hematoxylin–eosin staining). Data of MSC/dexa-treated condyles were compared with untreated, dexa-treated, MSC-treated, or normal unlesioned condyles. Results: The ratio between collagen type II expression versus collagen type I expression in MSC/dexa-treated condyles was higher than one, even though the group mean value was not statistically different from that of untreated defects. Histological changes were observed between MSC/dexa-treated and untreated defects mainly in surface regularity and in hyaline matrix abundance. However, International Cartilage Repair Society score analysis did not support robust differences between those groups. Conclusion: Intraarticular administration of dexamethasone after autologous MSC implantation into a preestablished full-thickness chondral defect does not contribute significantly to the regeneration of a tissue with molecular and histological characteristics identical to hyaline cartilage.

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Intravenous administration of bone marrow-derived multipotent mesenchymal stromal cells has a neutral effect on obesity-induced diabetic cardiomyopathy

2013 , Calligaris, Sebastián , CONGET MOLINA, PAULETTE ANDREA

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Acellular derivatives of mesenchymal stem cells prevent peritoneal adhesions in an animal model

2018 , Daniel Rojo , CONGET MOLINA, PAULETTE ANDREA

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The constructivist epistemological belief about scientific knowledge varies according to the year of training in medical students

2017 , Ximena Lazcano , Francisco Villalón , Soledad Vera , CONGET MOLINA, PAULETTE ANDREA

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The administration of multipotent stromal cells at precancerous stage precludes tumor growth and epithelial dedifferentiation of oral squamous cell carcinoma

2017 , FLAVIA ALEJANDRA BRUNA , Martha Arango-Rodríguez , Anita Plaza , Iris Espinoza , CONGET MOLINA, PAULETTE ANDREA

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Nosema ceranae an emergent pathogen of Apis mellifera in Chile

2012 , MARTINEZ ARENAS, JESSICA ISABEL , Germán Leal , Paulette Conget

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Identification of a Patient Cohort with Relapsing Diffuse Large B-Cell Lymphoma with a Low International Prognostic Index in PET/CT Using a 2-Gene (LMO2/TNFRSF9) Scoring System

2020 , Nader Omidvar , Nilgun Tekin , CONGET MOLINA, PAULETTE ANDREA , Flavia Bruna , Botond Timar , Eva Gagyi , Ranjan Basak , Chirayu Auewarakul , Narongrit Sritana , Juliano Julio Cerci , Mark Pierre Dimamay , Tamas Gyorke , Francisca Redondo , Reena Nair , Charity Gorospe , Diana Paez , Stefano Fanti , Hilal Ozdag , Rose Ann Padua , Robert Carr

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Novel and recurrent COL7A1 mutations in Chilean patients with dystrophic epidermolysis bullosa

2012 , Fernando A. Rodríguez , María José Gana , YUBERO GONCALVEZ, MARIA JOAO , Gisela Zillmann , Susanne M. Krämer , Javiera Catalán , Julia Rubio-Astudillo , Sergio González , Lu Liu , Linda Ozoemena , Jemima M. Mellerio , John A. McGrath , PALISSON ETCHARREN, FRANCIS , CONGET MOLINA, PAULETTE ANDREA

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Dynamic of distribution of human bone marrow-derived mesenchymal stem cells after transplantation into adult unconditioned mice

2004-08-27 , Allers, Carolina , Sierralta, Walter D. , Neubauer, Sonia , Rivera, Francisco , Minguell, José J. , CONGET MOLINA, PAULETTE ANDREA

Background. The use of mesenchymal stem cells (MSC) for cell therapy relies on their capacity to engraft and survive long term in the appropriate target tissue(s). Animal models have demonstrated that the syngeneic or xenogeneic transplantation of MSC results in donor engraftment into the bone marrow and other tissues of conditioned recipients. However, there are no reliable data showing the fate of human MSC infused into conditioned or unconditioned adult recipients. Methods. In the present study, the authors investigated, by using imaging, polymerase chain reaction (PCR), and in situ hybridization, the biodistribution of human bone marrow-derived MSC after intravenous infusion into unconditioned adult nude mice. Results. As assessed by imaging (gamma camera), PCR, and in situ hybridization analysis, the authors' results demonstrate the presence of human MSC in bone marrow, spleen, and mesenchymal tissues of recipient mice. Conclusions. These results suggest that human MSC transplantation into unconditioned recipients represents an option for providing cellular therapy and avoids the complications associated with drugs or radiation conditioning.

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