RETAMAL LUCERO, MAURICIO ANTONIO
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Preferred name
RETAMAL LUCERO, MAURICIO ANTONIO
Main Affiliation
Email
mretamal@udd.cl
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Scopus Author ID
8502472600

Research Output

2024 2024 2023 2023 2022 2022 2021 2021 2020 2020 2019 2019 2018 2018 2017 2017 2016 2016 2015 2015 0 0 2 2 4 4 6 6 8 8 10 10
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Ototoxicity induced by platinum-based chemotherapy

2022 , Cortés Fuentes , I.A., Hospital Barros Luco-Trudeau , University of Washington , RETAMAL LUCERO, MAURICIO ANTONIO

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Extracellular Cysteine in Connexins: Role as Redox Sensors

2016 , RETAMAL LUCERO, MAURICIO ANTONIO , Isaac E. García , Bernardo I. Pinto , Amaury Pupo , David Báez , Jimmy Stehberg , Rodrigo Del Rio , Carlos González

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4-Hydroxynonenal induces Cx46 hemichannel inhibition through its carbonylation

2020 , Mauricio A. Retamal , Mariana C. Fiori , Ainoa Fernandez-Olivares , Sergio Linsambarth , Francisca Peña , Daisy Quintana , Jimmy Stehberg , Guillermo A. Altenberg

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Cardiac remodeling and arrhythmogenesis are ameliorated by administration of Cx43 mimetic peptide Gap27 in heart failure rats

2020 , Claudia M. Lucero , David C. Andrade , Camilo Toledo , Hugo S. Díaz , Katherin V. Pereyra , Esteban Diaz-Jara , Karla G. Schwarz , Noah J. Marcus , RETAMAL LUCERO, MAURICIO ANTONIO , Rodrigo A. Quintanilla , Rodrigo Del Rio

AbstractAlterations in connexins and specifically in 43 isoform (Cx43) in the heart have been associated with a high incidence of arrhythmogenesis and sudden death in several cardiac diseases. We propose to determine salutary effect of Cx43 mimetic peptide Gap27 in the progression of heart failure. High-output heart failure was induced by volume overload using the arterio-venous fistula model (AV-Shunt) in adult male rats. Four weeks after AV-Shunt surgery, the Cx43 mimetic peptide Gap27 or scrambled peptide, were administered via osmotic minipumps (AV-ShuntGap27 or AV-ShuntScr) for 4 weeks. Cardiac volumes, arrhythmias, function and remodeling were determined at 8 weeks after AV-Shunt surgeries. At 8th week, AV-ShuntGap27 showed a marked decrease in the progression of cardiac deterioration and showed a significant improvement in cardiac functions measured by intraventricular pressure-volume loops. Furthermore, AV-ShuntGap27 showed less cardiac arrhythmogenesis and cardiac hypertrophy index compared to AV-ShuntScr. Gap27 treatment results in no change Cx43 expression in the heart of AV-Shunt rats. Our results strongly suggest that Cx43 play a pivotal role in the progression of cardiac dysfunction and arrhythmogenesis in high-output heart failure; furthermore, support the use of Cx43 mimetic peptide Gap27 as an effective therapeutic tool to reduce the progression of cardiac dysfunction in high-output heart failure.

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Remembrances of Dr. Michael V.L. Bennett by Iberoamerican Colleagues and Friends

2024 , Verónica Abudara , Ricardo C. Araneda , Luis Barrio , Viviana M. Berthoud , Jorge E. Contreras , Eliseo Eugenín , Juan Lerma , Juan A. Orellana , Nicolás Palacios-Prado , Elia Martha Pérez-Armendariz , RETAMAL LUCERO, MAURICIO ANTONIO , Juan C. Sáez

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Connexin43 Hemichannels in Satellite Glial Cells, Can They Influence Sensory Neuron Activity?

2017 , RETAMAL LUCERO, MAURICIO ANTONIO , Manuel A. Riquelme , Jimmy Stehberg , Julio Alcayaga

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Protocol for the Study of Connexin and DNA Interactions

2024 , Ainoa Fernandez-Olivares , RETAMAL LUCERO, MAURICIO ANTONIO

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Activation of Intra-nodose Ganglion P2X7 Receptors Elicit Increases in Neuronal Activity

2023 , Julio Alcayaga , Jorge Vera , Mauricio Reyna-Jeldes , Alejandra A. Covarrubias , Claudio Coddou , Esteban Díaz-Jara , Rodrigo Del Rio , RETAMAL LUCERO, MAURICIO ANTONIO

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Release of gliotransmitters through astroglial connexin 43 hemichannels is necessary for fear memory consolidation in the basolateral amygdala

2012 , Jimmy Stehberg , Rodrigo Moraga‐Amaro , Christian Salazar , Alvaro Becerra , Cesar Echeverría , Juan A. Orellana , Geert Bultynck , Raf Ponsaerts , Luc Leybaert , Felipe Simon , Juan C. Sáez , Mauricio A. Retamal

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ATP Is Required and Advances Cytokine-Induced Gap Junction Formation in Microglia In Vitro

2013 , Pablo J. Sáez , Kenji F. Shoji , RETAMAL LUCERO, MAURICIO ANTONIO , Paloma A. Harcha , Gigliola Ramírez , Jean X. Jiang , Rommy von Bernhardi , Juan C. Sáez

Microglia are the immune cells in the central nervous system. After injury microglia release bioactive molecules, including cytokines and ATP, which modify the functional state of hemichannels (HCs) and gap junction channels (GJCs), affecting the intercellular communication via extracellular and intracellular compartments, respectively. Here, we studied the role of extracellular ATP and several cytokines as modulators of the functional state of microglial HCs and GJCs using dye uptake and dye coupling techniques, respectively. In microglia and the microglia cell line EOC20, ATP advanced the TNF-α/IFN-γ-induced dye coupling, probably through the induction of IL-1βrelease. Moreover, TNF-α/IFN-γ, but not TNF-αplus ATP, increased dye uptake in EOC20 cells. Blockade of Cx43 and Panx1 HCs prevented dye coupling induced by TNF-α/IFN-γ, but not TNF-αplus ATP. In addition, IL-6 prevented the induction of dye coupling and HC activity induced by TNF-α/IFN-γin EOC20 cells. Our data support the notion that extracellular ATP affects the cellular communication between microglia through autocrine and paracrine mechanisms, which might affect the timing of immune response under neuroinflammatory conditions.

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