BEHRENS PELLEGRINO, MARIA ISABEL
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BEHRENS PELLEGRINO, MARIA ISABEL
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BEHRENS PELLEGRINO, MARIA ISABEL
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mbehrens@udd.cl
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7007110355

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Frequency and Determinants of Poststroke Cognitive Impairment at Three and Twelve Months in Chile

2010 , Carolina Delgado , Archibaldo Donoso , Patricia Orellana , Carolina Vásquez , DIAZ TAPIA, VIOLETA DEL CARMEN , BEHRENS PELLEGRINO, MARIA ISABEL

A higher risk of poststroke cognitive impairment (CI) has been reported in Hispanics in a US cohort but has not been systematically studied in Latin America. <i>Objectives:</i> Our purpose was to investigate the frequencies and determinants of poststroke CI in the hispano-mestizo population of Santiago, Chile. <i>Methods:</i> A prospective study of hospitalized patients aged >60 years admitted with an ischemic or hemorrhagic stroke was conducted. The cognitive status was determined at 3 and 12 months after the stroke by informant questionnaires, neuropsychological testing and clinical diagnosis. Cardiovascular risk factors, brain imaging and stroke features were analyzed using regression models to establish determinants for poststroke CI. <i>Results:</i> A total of 164 patients (mean age = 72 ± 7.5 years) were recruited. Out of 122 patients (74%) evaluated at 3 months, 81 (66%) had CI. Out of 101 patients (62%) evaluated at 12 months, 39 (39%) had CI no dementia, and 22 (22%) were demented. The new-onset dementia frequency at 1 year was 16%. Independent determinants for dementia were higher functional impairment at hospital egress (OR = 4.0), left-hemisphere large-vessel infarction (OR = 6.9) and a larger amount of white matter changes (OR = 1.3). <i>Conclusions:</i> In this first study on poststroke CI in Latin America, the frequencies and determinants of poststroke CI were similar to those in other cohorts of different ethnic origin.

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Inverse Susceptibility to Oxidative Death of Lymphocytes Obtained From Alzheimer's Patients and Skin Cancer Survivors: Increased Apoptosis in Alzheimer's and Reduced Necrosis in Cancer

2012 , BEHRENS PELLEGRINO, MARIA ISABEL , M. Silva , F. Salech , D. P. Ponce , D. Merino , Sinning, Mariana , Xiong, Chengjie , C. M. Roe , A. F. G. Quest

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Validación del instrumento Montreal Cognitive Assessment en español en adultos mayores de 60 años

2019 , C. Delgado , A. Araneda , BEHRENS PELLEGRINO, MARIA ISABEL

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Clinical spectrum of Kufor-Rakeb syndrome in the Chilean kindred with ATP13A2 mutations

2010 , BEHRENS PELLEGRINO, MARIA ISABEL , Norbert Brüggemann , Pedro Chana , Pablo Venegas , Marianne Kägi , Teresa Parrao , Patricia Orellana , Cristian Garrido , Cecilia V. Rojas , Jan Hauke , Eric Hahnen , Rafael González , Nicolas Seleme , Verónica Fernández , Alexander Schmidt , Ferdinand Binkofski , Detlef Kömpf , Christian Kubisch , Johann Hagenah , Christine Klein , Alfredo Ramirez

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The BrainLat project, a multimodal neuroimaging dataset of neurodegeneration from underrepresented backgrounds

2023 , Pavel Prado , Vicente Medel , Raul Gonzalez-Gomez , Agustín Sainz-Ballesteros , Victor Vidal , Hernando Santamaría-García , Sebastian Moguilner , Jhony Mejia , SLACHEVSKY CHONCHOL, ANDREA MARÍA , BEHRENS PELLEGRINO, MARIA ISABEL , David Aguillon , Francisco Lopera , Mario A. Parra , Diana Matallana , Marcelo Adrián Maito , Adolfo M. Garcia , Nilton Custodio , Alberto Ávila Funes , Stefanie Piña-Escudero , Agustina Birba , Sol Fittipaldi , Agustina Legaz , Agustín Ibañez

The Latin American Brain Health Institute (BrainLat) has released a unique multimodal neuroimaging dataset of 780 participants from Latin American. The dataset includes 530 patients with neurodegenerative diseases such as Alzheimer’s disease (AD), behavioral variant frontotemporal dementia (bvFTD), multiple sclerosis (MS), Parkinson’s disease (PD), and 250 healthy controls (HCs). This dataset (62.7 ± 9.5 years, age range 21–89 years) was collected through a multicentric effort across five Latin American countries to address the need for affordable, scalable, and available biomarkers in regions with larger inequities. The BrainLat is the first regional collection of clinical and cognitive assessments, anatomical magnetic resonance imaging (MRI), resting-state functional MRI (fMRI), diffusion-weighted MRI (DWI), and high density resting-state electroencephalography (EEG) in dementia patients. In addition, it includes demographic information about harmonized recruitment and assessment protocols. The dataset is publicly available to encourage further research and development of tools and health applications for neurodegeneration based on multimodal neuroimaging, promoting the assessment of regional variability and inclusion of underrepresented participants in research.

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Frontotemporal Dementias in Latin America: History, Epidemiology, Genetics, and Clinical Research

2021 , Jorge J. Llibre-Guerra , BEHRENS PELLEGRINO, MARIA ISABEL , Mirna Lie Hosogi , Lucia Montero , Teresa Torralva , Nilton Custodio , Erika Mariana Longoria-Ibarrola , Margarita Giraldo-Chica , David Aguillón , Angela Hardi , Gladys E. Maestre , Valeria Contreras , Celeste Doldan , Lissette Duque-Peñailillo , Heike Hesse , Norbel Roman , Dhara Angelina Santana-Trinidad , Christian Schenk , Ninoska Ocampo-Barba , Ricardo López-Contreras , Ricardo Nitrini

Introduction: The historical development, frequency, and impact of frontotemporal dementia (FTD) are less clear in Latin America than in high-income countries. Although there is a growing number of dementia studies in Latin America, little is known collectively about FTD prevalence studies by country, clinical heterogeneity, risk factors, and genetics in Latin American countries.Methods: A systematic review was completed, aimed at identifying the frequency, clinical heterogeneity, and genetics studies of FTD in Latin American populations. The search strategies used a combination of standardized terms for FTD and related disorders. In addition, at least one author per Latin American country summarized the available literature. Collaborative or regional studies were reviewed during consensus meetings.Results: The first FTD reports published in Latin America were mostly case reports. The last two decades marked a substantial increase in the number of FTD research in Latin American countries. Brazil (165), Argentina (84), Colombia (26), and Chile (23) are the countries with the larger numbers of FTD published studies. Most of the research has focused on clinical and neuropsychological features (n = 247), including the local adaptation of neuropsychological and behavioral assessment batteries. However, there are little to no large studies on prevalence (n = 4), biomarkers (n = 9), or neuropathology (n = 3) of FTD.Conclusions: Future FTD studies will be required in Latin America, albeit with a greater emphasis on clinical diagnosis, genetics, biomarkers, and neuropathological studies. Regional and country-level efforts should seek better estimations of the prevalence, incidence, and economic impact of FTD syndromes.

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Neuronal Rubicon Represses Extracellular APP/Amyloid β Deposition in Alzheimer’s Disease

2022 , Sandra Espinoza , Felipe Grunenwald , Wileidy Gomez , Felipe García , Lorena Abarzúa-Catalan , Sebastián Oyarce-Pezoa , Maria Fernanda Hernandez , Bastián I. Cortés , Markus Uhrig , Daniela P. Ponce , Claudia Durán-Aniotz , Claudio Hetz , Carol D. SanMartín , Victor H. Cornejo , EZQUER, EDUARDO FERNANDO , Valentina Parra , BEHRENS PELLEGRINO, MARIA ISABEL , Patricio A. Manque , Diego Rojas-Rivera , René L. Vidal , Ute Woehlbier , Melissa Nassif

Alzheimer’s disease (AD) is the most prevalent age-associated neurodegenerative disease. A decrease in autophagy during aging contributes to brain disorders by accumulating potentially toxic substrates in neurons. Rubicon is a well-established inhibitor of autophagy in all cells. However, Rubicon participates in different pathways depending on cell type, and little information is currently available on neuronal Rubicon’s role in the AD context. Here, we investigated the cell-specific expression of Rubicon in postmortem brain samples from AD patients and 5xFAD mice and its impact on amyloid β burden in vivo and neuroblastoma cells. Further, we assessed Rubicon levels in human-induced pluripotent stem cells (hiPSCs), derived from early-to-moderate AD and in postmortem samples from severe AD patients. We found increased Rubicon levels in AD-hiPSCs and postmortem samples and a notable Rubicon localization in neurons. In AD transgenic mice lacking Rubicon, we observed intensified amyloid β burden in the hippocampus and decreased Pacer and p62 levels. In APP-expressing neuroblastoma cells, increased APP/amyloid β secretion in the medium was found when Rubicon was absent, which was not observed in cells depleted of Atg5, essential for autophagy, or Rab27a, required for exosome secretion. Our results propose an uncharacterized role of Rubicon on APP/amyloid β homeostasis, in which neuronal Rubicon is a repressor of APP/amyloid β secretion, defining a new way to target AD and other similar diseases therapeutically.

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The Impact of a Yoga-Based Mindfulness Intervention versus Psycho-Educational Session for Older Adults with Mild Cognitive Impairment: The Protocol of a Randomized Controlled Trial

2022 , Maryam Farhang , Graciela Rojas , Pablo Martínez , BEHRENS PELLEGRINO, MARIA ISABEL , Álvaro I. Langer , Marcela Diaz , Claudia Miranda-Castillo

Background: There is a global agreement in the medical community that a significant proportion of dementia cases could be prevented or postponed. One of the factors behind this agreement comes from scientific evidence showing that mind-body interventions such as mindfulness and yoga for the elderly have been related to a range of positive outcomes, including improved cognition performance in seniors with mild cognitive impairment (MCI). Objective: This study aims to evaluate the effectiveness of a yoga-based mindfulness intervention (YBM) versus psychoeducational sessions for older adults with MCI attending Hospital Clinic Universidad de Chile in Santiago. Method: Two-arm, individually randomized controlled trial (RCT) will be carried out at Clinical Hospital Universidad de Chile in Santiago. Older people over 60 years with any type of MCI using a score < 21 in the Montreal Cognitive Assessment (MoCA) test and a score of 0.05 in the Clinical Dementia Rating (CDR) Scale; and with preserved activities of daily living will be randomly assigned with an allocation ratio of 1:1 in either the yoga-based mindfulness intervention or the active control group based on the psycho-educational program. People who have performed yoga and/or mindfulness in the last 6 months or/and people with a psychiatric clinical diagnosis will be excluded from the study. Montreal Cognitive Assessment, the Lawton Instrumental Activities of Daily Living Scale (IADL), the Barthel Index (BI), the Pemberton happiness index, the Geriatric Anxiety Inventory (GAI) as well as the Geriatric Depression Scale (GDS-5) will be administered by blinded outcomes assessors before random assignment (Pre-test), the week following the last session of the intervention (post-test), and then after 3- and 6-months follow-up. Results: The YBM intervention protocol based on a video recording has been adapted and designed. This is the first RCT to examine the effects of a yoga-based mindfulness intervention in improving cognitive and physical functions and mental health outcomes for Chilean elderly diagnosed with MCI. It is expected to be implemented as an acceptable and effective non-pharmacological option for older people with MCI. Conclusion: Providing evidence-based programs such as preventive therapy for Alzheimer’s disease has relevant implications for public mental health services in Chile.

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Author Correction: The BrainLat project, a multimodal neuroimaging dataset of neurodegeneration from underrepresented backgrounds

2024 , Pavel Prado , Vicente Medel , Raul Gonzalez-Gomez , Agustín Sainz-Ballesteros , Victor Vidal , Hernando Santamaría-García , Sebastian Moguilner , Jhony Mejia , SLACHEVSKY CHONCHOL, ANDREA MARÍA , BEHRENS PELLEGRINO, MARIA ISABEL , David Aguillon , Francisco Lopera , Mario A. Parra , Diana Matallana , Marcelo Adrián Maito , Adolfo M. Garcia , Nilton Custodio , Alberto Ávila Funes , Stefanie Piña-Escudero , Agustina Birba , Sol Fittipaldi , Agustina Legaz , Agustín Ibañez

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Frizzled-1 receptor regulates adult hippocampal neurogenesis

2016 , Muriel D. Mardones , Gabriela A. Andaur , Manuel Varas-Godoy , Jenny F. Henriquez , Felipe Salech , BEHRENS PELLEGRINO, MARIA ISABEL , Andrés Couve , Nibaldo C. Inestrosa , Lorena Varela-Nallar

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