BEHRENS PELLEGRINO, MARIA ISABEL
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BEHRENS PELLEGRINO, MARIA ISABEL
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BEHRENS PELLEGRINO, MARIA ISABEL
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mbehrens@udd.cl
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7007110355

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Frequency and Determinants of Poststroke Cognitive Impairment at Three and Twelve Months in Chile

2010 , Carolina Delgado , Archibaldo Donoso , Patricia Orellana , Carolina Vásquez , DIAZ TAPIA, VIOLETA DEL CARMEN , BEHRENS PELLEGRINO, MARIA ISABEL

A higher risk of poststroke cognitive impairment (CI) has been reported in Hispanics in a US cohort but has not been systematically studied in Latin America. <i>Objectives:</i> Our purpose was to investigate the frequencies and determinants of poststroke CI in the hispano-mestizo population of Santiago, Chile. <i>Methods:</i> A prospective study of hospitalized patients aged >60 years admitted with an ischemic or hemorrhagic stroke was conducted. The cognitive status was determined at 3 and 12 months after the stroke by informant questionnaires, neuropsychological testing and clinical diagnosis. Cardiovascular risk factors, brain imaging and stroke features were analyzed using regression models to establish determinants for poststroke CI. <i>Results:</i> A total of 164 patients (mean age = 72 ± 7.5 years) were recruited. Out of 122 patients (74%) evaluated at 3 months, 81 (66%) had CI. Out of 101 patients (62%) evaluated at 12 months, 39 (39%) had CI no dementia, and 22 (22%) were demented. The new-onset dementia frequency at 1 year was 16%. Independent determinants for dementia were higher functional impairment at hospital egress (OR = 4.0), left-hemisphere large-vessel infarction (OR = 6.9) and a larger amount of white matter changes (OR = 1.3). <i>Conclusions:</i> In this first study on poststroke CI in Latin America, the frequencies and determinants of poststroke CI were similar to those in other cohorts of different ethnic origin.

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Usefulness of a brief informant interview to detect Dementia, translated into Spanish (AD8-Ch

2010-08 , Muñoz, Carlos , Núñez, Javier , Flores, Patricia , BEHRENS PELLEGRINO, MARIA ISABEL , Slachevsky, Andrea

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Frizzled-1 receptor regulates adult hippocampal neurogenesis

2016 , Muriel D. Mardones , Gabriela A. Andaur , Manuel Varas-Godoy , Jenny F. Henriquez , Felipe Salech , BEHRENS PELLEGRINO, MARIA ISABEL , Andrés Couve , Nibaldo C. Inestrosa , Lorena Varela-Nallar

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Red neural por defecto y enfermedad de Alzheimer

2013 , Vergara, Fernando , BEHRENS PELLEGRINO, MARIA ISABEL

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Frontotemporal Dementias in Latin America: History, Epidemiology, Genetics, and Clinical Research

2021 , Jorge J. Llibre-Guerra , BEHRENS PELLEGRINO, MARIA ISABEL , Mirna Lie Hosogi , Lucia Montero , Teresa Torralva , Nilton Custodio , Erika Mariana Longoria-Ibarrola , Margarita Giraldo-Chica , David Aguillón , Angela Hardi , Gladys E. Maestre , Valeria Contreras , Celeste Doldan , Lissette Duque-Peñailillo , Heike Hesse , Norbel Roman , Dhara Angelina Santana-Trinidad , Christian Schenk , Ninoska Ocampo-Barba , Ricardo López-Contreras , Ricardo Nitrini

Introduction: The historical development, frequency, and impact of frontotemporal dementia (FTD) are less clear in Latin America than in high-income countries. Although there is a growing number of dementia studies in Latin America, little is known collectively about FTD prevalence studies by country, clinical heterogeneity, risk factors, and genetics in Latin American countries.Methods: A systematic review was completed, aimed at identifying the frequency, clinical heterogeneity, and genetics studies of FTD in Latin American populations. The search strategies used a combination of standardized terms for FTD and related disorders. In addition, at least one author per Latin American country summarized the available literature. Collaborative or regional studies were reviewed during consensus meetings.Results: The first FTD reports published in Latin America were mostly case reports. The last two decades marked a substantial increase in the number of FTD research in Latin American countries. Brazil (165), Argentina (84), Colombia (26), and Chile (23) are the countries with the larger numbers of FTD published studies. Most of the research has focused on clinical and neuropsychological features (n = 247), including the local adaptation of neuropsychological and behavioral assessment batteries. However, there are little to no large studies on prevalence (n = 4), biomarkers (n = 9), or neuropathology (n = 3) of FTD.Conclusions: Future FTD studies will be required in Latin America, albeit with a greater emphasis on clinical diagnosis, genetics, biomarkers, and neuropathological studies. Regional and country-level efforts should seek better estimations of the prevalence, incidence, and economic impact of FTD syndromes.

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Increased susceptibility to oxidative death of lymphocytes from Alzheimer patients correlates with dementia severity

2014-03 , Ponce, Daniela , Salech, Felipe , Sanmartin, Carol , Silva, Mónica , Xiong, Chengjie , Henriquez, Mauricio , Quest, Andrew F. , BEHRENS PELLEGRINO, MARIA ISABEL

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Inverse Susceptibility to Oxidative Death of Lymphocytes Obtained From Alzheimer's Patients and Skin Cancer Survivors: Increased Apoptosis in Alzheimer's and Reduced Necrosis in Cancer

2012 , BEHRENS PELLEGRINO, MARIA ISABEL , M. Silva , F. Salech , D. P. Ponce , D. Merino , Sinning, Mariana , Xiong, Chengjie , C. M. Roe , A. F. G. Quest

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Author Correction: The BrainLat project, a multimodal neuroimaging dataset of neurodegeneration from underrepresented backgrounds

2024 , Pavel Prado , Vicente Medel , Raul Gonzalez-Gomez , Agustín Sainz-Ballesteros , Victor Vidal , Hernando Santamaría-García , Sebastian Moguilner , Jhony Mejia , SLACHEVSKY CHONCHOL, ANDREA MARÍA , BEHRENS PELLEGRINO, MARIA ISABEL , David Aguillon , Francisco Lopera , Mario A. Parra , Diana Matallana , Marcelo Adrián Maito , Adolfo M. Garcia , Nilton Custodio , Alberto Ávila Funes , Stefanie Piña-Escudero , Agustina Birba , Sol Fittipaldi , Agustina Legaz , Agustín Ibañez

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Clinical spectrum of Kufor-Rakeb syndrome in the Chilean kindred with ATP13A2 mutations

2010 , BEHRENS PELLEGRINO, MARIA ISABEL , Norbert Brüggemann , Pedro Chana , Pablo Venegas , Marianne Kägi , Teresa Parrao , Patricia Orellana , Cristian Garrido , Cecilia V. Rojas , Jan Hauke , Eric Hahnen , Rafael González , Nicolas Seleme , Verónica Fernández , Alexander Schmidt , Ferdinand Binkofski , Detlef Kömpf , Christian Kubisch , Johann Hagenah , Christine Klein , Alfredo Ramirez

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Senescence Markers in Peripheral Blood Mononuclear Cells in Amnestic Mild Cognitive Impairment and Alzheimer’s Disease

2022 , Felipe Salech , Carol D. SanMartín , Jorge Concha-Cerda , Esteban Romero-Hernández , Daniela P. Ponce , Gianella Liabeuf , Nicole K. Rogers , Paola Murgas , Bárbara Bruna , Jamileth More , BEHRENS PELLEGRINO, MARIA ISABEL

Recent studies suggest that cellular senescence plays a role in Alzheimer’s Disease (AD) pathogenesis. We hypothesize that cellular senescence markers might be tracked in the peripheral tissues of AD patients. Senescence hallmarks, including altered metabolism, cell-cycle arrest, DNA damage response (DDR) and senescence secretory associated phenotype (SASP), were measured in peripheral blood mononuclear cells (PBMCs) of healthy controls (HC), amnestic mild cognitive impairment (aMCI) and AD patients. Senescence-associated βeta-galactosidase (SA-β-Gal) activity, G0-G1 phase cell-cycle arrest, p16 and p53 were analyzed by flow cytometry, while IL-6 and IL-8 mRNA were analyzed by qPCR, and phosphorylated H2A histone family member X (γH2AX) was analyzed by immunofluorescence. Senescent cells in the brain tissue were determined with lipofuscin staining. An increase in the number of senescent cells was observed in the frontal cortex and hippocampus of advanced AD patients. PBMCs of aMCI patients, but not in AD, showed increased SA-β-Gal compared with HCs. aMCI PBMCs also had increased IL-6 and IL8 mRNA expression and number of cells arrested at G0-G1, which were absent in AD. Instead, AD PBMCs had significantly increased p16 and p53 expression and decreased γH2Ax activity compared with HC. This study reports that several markers of cellular senescence can be measured in PBMCs of aMCI and AD patients.

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