Research Output

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Publication

Fluid transport in high volume fly ash mixtures with and without internal curing

2014 , Igor De la Varga , Robert P. Spragg , Carmelo Di Bella , CASTRO SEPÚLVEDA, JAVIER EDUARDO , Dale P. Bentz , Jason Weiss

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Evaluation of Portland and Pozzolanic cement on the self-healing of mortars with calcium lactate and bacteria

2020 , Álvaro González , Araceli Parraguez , Liliana Corvalán , Néstor Correa , CASTRO SEPÚLVEDA, JAVIER EDUARDO , Claudia Stuckrath , Marcelo González

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Massive volume fly-ash concrete: A more sustainable material with fly ash replacing cement and aggregates

2015 , Felipe Rivera , Patricia Martínez , CASTRO SEPÚLVEDA, JAVIER EDUARDO , Mauricio López

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Thermo-mechanical assessment of concrete microcracking damage due to early-age temperature rise

2015 , Franco Zunino , CASTRO SEPÚLVEDA, JAVIER EDUARDO , Mauricio Lopez

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Reducing setting time of blended cement paste containing high-SO3 fly ash (HSFA) using chemical/physical accelerators and by fly ash pre-washing

2018 , Franco Zunino , Dale P. Bentz , CASTRO SEPÚLVEDA, JAVIER EDUARDO

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Evaluating the hydration of high volume fly ash mixtures using chemically inert fillers

2018 , Igor De la Varga , CASTRO SEPÚLVEDA, JAVIER EDUARDO , Dale P. Bentz , Franco Zunino , Jason Weiss

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Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ): Rationale and Study Design of the Largest Global Prospective Cohort Study of Clinical High Risk for Psychosis

2024 , Cassandra M J Wannan , Barnaby Nelson , Jean Addington , Kelly Allott , Alan Anticevic , Celso Arango , Justin T Baker , Carrie E Bearden , Tashrif Billah , Sylvain Bouix , Matthew R Broome , Kate Buccilli , Kristin S Cadenhead , Monica E Calkins , Tyrone D Cannon , Guillermo Cecci , Eric Yu Hai Chen , Kang Ik K Cho , Jimmy Choi , Scott R Clark , Michael J Coleman , Philippe Conus , Cheryl M Corcoran , Barbara A Cornblatt , Covadonga M Diaz-Caneja , Dominic Dwyer , Bjørn H Ebdrup , Lauren M Ellman , Paolo Fusar-Poli , Liliana Galindo , Pablo A Gaspar , Carla Gerber , Louise Birkedal Glenthøj , Robert Glynn , Michael P Harms , Leslie E Horton , René S Kahn , Joseph Kambeitz , Lana Kambeitz-Ilankovic , John M Kane , Tina Kapur , Matcheri S Keshavan , Sung-Wan Kim , Nikolaos Koutsouleris , Marek Kubicki , Jun Soo Kwon , Kerstin Langbein , Kathryn E Lewandowski , Gregory A Light , Daniel Mamah , Patricia J Marcy , Daniel H Mathalon , Patrick D McGorry , Vijay A Mittal , Merete Nordentoft , Angela Nunez , Ofer Pasternak , Godfrey D Pearlson , Jesus Perez , Diana O Perkins , Albert R Powers , David R Roalf , Fred W Sabb , Jason Schiffman , Jai L Shah , Stefan Smesny , Jessica Spark , William S Stone , Gregory P Strauss , Zailyn Tamayo , John Torous , Rachel Upthegrove , Mark Vangel , Swapna Verma , Jijun Wang , Inge Winter-van Rossum , Daniel H Wolf , Phillip Wolff , Stephen J Wood , Alison R Yung , Carla Agurto , Mario Alvarez-Jimenez , Paul Amminger , Marco Armando , Ameneh Asgari-Targhi , John Cahill , Ricardo E Carrión , Eduardo Castro , Suheyla Cetin-Karayumak , M Mallar Chakravarty , Youngsun T Cho , David Cotter , Simon D’Alfonso , Michaela Ennis , Shreyas Fadnavis , Clara Fonteneau , Caroline Gao , Tina Gupta , Raquel E Gur , Ruben C Gur , Holly K Hamilton , Gil D Hoftman , Grace R Jacobs , Johanna Jarcho , Jie Lisa Ji , Christian G Kohler , Paris Alexandros Lalousis , Suzie Lavoie , Martin Lepage , Einat Liebenthal , Josh Mervis , Vishnu Murty , Spero C Nicholas , Lipeng Ning , Nora Penzel , Russell Poldrack , Pablo Polosecki , Danielle N Pratt , Rachel Rabin , Habiballah Rahimi Eichi , Yogesh Rathi , Avraham Reichenberg , Jenna Reinen , Jack Rogers , Bernalyn Ruiz-Yu , Isabelle Scott , Johanna Seitz-Holland , Vinod H Srihari , Agrima Srivastava , Andrew Thompson , Bruce I Turetsky , Barbara C Walsh , Thomas Whitford , Johanna T W Wigman , Beier Yao , Hok Pan Yuen , Uzair Ahmed , Andrew (Jin Soo) Byun , Yoonho Chung , Kim Do , Larry Hendricks , Kevin Huynh , Clark Jeffries , Erlend Lane , Carsten Langholm , Eric Lin , Valentina Mantua , Gennarina Santorelli , Kosha Ruparel , Eirini Zoupou , Tatiana Adasme , Lauren Addamo , Laura Adery , Munaza Ali , Andrea Auther , Samantha Aversa , Seon-Hwa Baek , Kelly Bates , Alyssa Bathery , Johanna M M Bayer , Rebecca Beedham , Zarina Bilgrami , Sonia Birch , Ilaria Bonoldi , Owen Borders , Renato Borgatti , Lisa Brown , Alejandro Bruna , Holly Carrington , Rolando I Castillo-Passi , Justine Chen , Nicholas Cheng , Ann Ee Ching , Chloe Clifford , Beau-Luke Colton , Pamela Contreras , Sebastián Corral , Stefano Damiani , Monica Done , Andrés Estradé , Brandon Asika Etuka , Melanie Formica , Rachel Furlan , Mia Geljic , Carmela Germano , Ruth Getachew , Mathias Goncalves , Anastasia Haidar , Jessica Hartmann , Anna Jo , Omar John , Sarah Kerins , Melissa Kerr , Irena Kesselring , Honey Kim , Nicholas Kim , Kyle Kinney , Marija Krcmar , Elana Kotler , Melanie Lafanechere , Clarice Lee , Joshua Llerena , Christopher Markiewicz , Priya Matnejl , Alejandro Maturana , Aissata Mavambu , Rocío Mayol-Troncoso , Amelia McDonnell , Alessia McGowan , Danielle McLaughlin , Rebecca McIlhenny , Brittany McQueen , Yohannes Mebrahtu , Martina Mensi , Christy Lai Ming Hui , Yi Nam Suen , Stephanie Ming Yin Wong , Neal Morrell , Mariam Omar , Alice Partridge , Christina Phassouliotis , Anna Pichiecchio , Pierluigi Politi , Christian Porter , Umberto Provenzani , Nicholas Prunier , Jasmine Raj , Susan Ray , Victoria Rayner , Manuel Reyes , Kate Reynolds , Sage Rush , Cesar Salinas , Jashmina Shetty , Callum Snowball , Sophie Tod , Gabriel Turra-Fariña , Daniela Valle , Simone Veale , Sarah Whitson , Alana Wickham , Sarah Youn , Francisco Zamorano , Elissa Zavaglia , Jamie Zinberg , Scott W Woods , Martha E Shenton

Abstract This article describes the rationale, aims, and methodology of the Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ). This is the largest international collaboration to date that will develop algorithms to predict trajectories and outcomes of individuals at clinical high risk (CHR) for psychosis and to advance the development and use of novel pharmacological interventions for CHR individuals. We present a description of the participating research networks and the data processing analysis and coordination center, their processes for data harmonization across 43 sites from 13 participating countries (recruitment across North America, Australia, Europe, Asia, and South America), data flow and quality assessment processes, data analyses, and the transfer of data to the National Institute of Mental Health (NIMH) Data Archive (NDA) for use by the research community. In an expected sample of approximately 2000 CHR individuals and 640 matched healthy controls, AMP SCZ will collect clinical, environmental, and cognitive data along with multimodal biomarkers, including neuroimaging, electrophysiology, fluid biospecimens, speech and facial expression samples, novel measures derived from digital health technologies including smartphone-based daily surveys, and passive sensing as well as actigraphy. The study will investigate a range of clinical outcomes over a 2-year period, including transition to psychosis, remission or persistence of CHR status, attenuated positive symptoms, persistent negative symptoms, mood and anxiety symptoms, and psychosocial functioning. The global reach of AMP SCZ and its harmonized innovative methods promise to catalyze the development of new treatments to address critical unmet clinical and public health needs in CHR individuals.