EZQUER, EDUARDO FERNANDO
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EZQUER, EDUARDO FERNANDO
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eezquer@udd.cl
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8614146900

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ANTI-INFLAMMATORY MESENCHYMAL STEM CELLS AND N-ACETYL CYSTEINE INHIBIT CHRONIC ETHANOL INTAKE AND ABOLISH RELAPSE BINGE DRINKING: PRECLINICAL STUDIES

2018 , EZQUER, EDUARDO FERNANDO , EZQUER, EDUARDO MARCELO , Daniela Santapau , Yedy Israel , QUINTANILLA, M.E. , MORALES, P. , LESLAY REBOLLEDO, C. , HERRERA MARSCHITZ, M.

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Material Suplementario - Genome Sequencing Variations in the Octodon degus, an Unconventional Natural Model of Aging and Alzheimer's Disease

2022 , EZQUER, EDUARDO MARCELO , EZQUER, EDUARDO FERNANDO

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Insulin is secreted upon glucose stimulation by both gastrointestinal enteroendocrine K-cells and L-cells engineered with the preproinsulin gene

2011 , Gonzalo Encina , EZQUER, EDUARDO FERNANDO , CONGET MOLINA, PAULETTE ANDREA , Yedy Israel

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The Reparative Abilities of Menstrual Stem Cells Modulate the Wound Matrix Signals and Improve Cutaneous Regeneration

2018 , Jimena Cuenca , Alice Le-Gatt , Valentina Castillo , Jose Belletti , Macarena Díaz , Mónica Kurte G , Paz L. Gonzalez , Francisca Alcayaga-Miranda , Christina M. A. P. Schuh , EZQUER, EDUARDO FERNANDO , EZQUER, EDUARDO MARCELO , Maroun Khoury

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Intracerebral Stem Cell Administration Inhibits Relapse-like Alcohol Drinking in Rats

2016 , Yedy Israel , EZQUER, EDUARDO FERNANDO , María Elena Quintanilla , Paola Morales , EZQUER, EDUARDO MARCELO , Mario Herrera-Marschitz

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IMMUNOMODULATORY AND REGENERATIVE PROPERTIES OF HUMAN MENSENCHYMAL STEM CELLS SECRETOME, PREVENT HEPATIC AND RENAL MULTIPLE ORGAN DYSFUNCTION IN A RAT MODEL OF ACUTE ON CHRONIC LIVER FAILURE

2023 , EZQUER, EDUARDO FERNANDO , EZQUER, EDUARDO MARCELO

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MSC transplantation: a promising therapeutic strategy to manage the onset and progression of diabetic nephropathy

2012 , EZQUER, EDUARDO MARCELO , EZQUER, EDUARDO FERNANDO , Martha L Arango-Rodríguez , Paulette A Conget

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Schizophrenia-derived hiPSC brain microvascular endothelial-like cells show impairments in angiogenesis and blood–brain barrier function

2022 , Bárbara S. Casas , Gabriela Vitória , Catalina P. Prieto , Mariana Casas , Carlos Chacón , Markus Uhrig , EZQUER, EDUARDO FERNANDO , Stevens K. Rehen , EZQUER, EDUARDO MARCELO , Verónica Palma

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Aspirin and N‐acetylcysteine co‐administration markedly inhibit chronic ethanol intake and block relapse binge drinking: Role of neuroinflammation‐oxidative stress self‐perpetuation

2019 , Yedy Israel , María Elena Quintanilla , EZQUER, EDUARDO FERNANDO , Paola Morales , Daniela Santapau , BERRIOS CARCAMO, PABLO ANDRES , EZQUER, EDUARDO MARCELO , OLIVARES, MARIA BELEN , Mario Herrera‐Marschitz

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New Perspectives to Improve Mesenchymal Stem Cell Therapies for Drug-Induced Liver Injury

2022 , EZQUER, EDUARDO FERNANDO , HUANG, YA LIN , EZQUER, EDUARDO MARCELO

Drug-induced liver injury (DILI) is one of the leading causes of acute liver injury. Many factors may contribute to the susceptibility of patients to this condition, making DILI a global medical problem that has an impact on public health and the pharmaceutical industry. The use of mesenchymal stem cells (MSCs) has been at the forefront of regenerative medicine therapies for many years, including MSCs for the treatment of liver diseases. However, there is currently a huge gap between these experimental approaches and their application in clinical practice. In this concise review, we focus on the pathophysiology of DILI and highlight new experimental approaches conceived to improve cell-based therapy by the in vitro preconditioning of MSCs and/or the use of cell-free products as treatment for this liver condition. Finally, we discuss the advantages of new approaches, but also the current challenges that must be addressed in order to develop safer and more effective procedures that will allow cell-based therapies to reach clinical practice, enhancing the quality of life and prolonging the survival time of patients with DILI.

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