Research Output

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Cerebral and pulmonary fat embolism after unilateral total knee arthroplasty

2019 , FIGUEROA POBLETE, DAVID HUMBERTO , FIGUEROA BERRIOS, FRANCISCO JAVIER , Rafael Calvo Mena , Figueroa, María

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Uso del plasma rico en plaquetas en cirugía ligamentosa de rodilla

2013 , FIGUEROA POBLETE, DAVID HUMBERTO , FIGUEROA BERRIOS, FRANCISCO JAVIER , Ahumada P Ximena , CALVO RODRIGUEZ, RAFAEL , Alex Vaisman B

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Aloinjertos óseos y la función del banco de huesos

2011 , CALVO RODRIGUEZ, RAFAEL , FIGUEROA POBLETE, DAVID HUMBERTO , Claudio Díaz-Ledezma , Alex Vaisman , FIGUEROA BERRIOS, FRANCISCO JAVIER

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Orthopedic surgery residents’ perception of online education in their programs during the COVID-19 pandemic: should it be maintained after the crisis?

2020 , FIGUEROA BERRIOS, FRANCISCO JAVIER , FIGUEROA POBLETE, DAVID HUMBERTO , Rafael Calvo-Mena , Felipe Narvaez , Natalia Medina , Juan Prieto

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Intraarticular Administration of Dexamethasone after Mesenchymal Stem Cells Implantation Does Not Improve Significantly the Treatment of Preestablished Full-Thickness Chondral Defect in a Rabbit Model

2013 , Maximiliano Espinosa , Alex Vaisman , Nicolas Nazal , FIGUEROA POBLETE, DAVID HUMBERTO , Marcela Gallegos , CONGET MOLINA, PAULETTE ANDREA

Objective: The aim of this study was to evaluate the contribution to hyaline cartilage regeneration of dexamethasone intraarticular administration after autologous mesenchymal stem cells (MSCs) implantation into a preestablished knee full-thickness chondral defect. Design: Full-thickness chondral defects of 4.5 × 4.5 mm2 were surgically made in both medial femoral condyles of adult male New Zealand rabbits. Two weeks later, autologous ex vivo expanded bone marrow–derived MSCs were embedded in hyaluronic acid and implanted into the chondral defects. Immediately and every week after the intervention, dexamethasone 0.25 mg/kg was intraarticularly administered (MSC/dexa-treated group). Six weeks after MSC transplantation, the animals were euthanized and condyles were characterized molecularly according to aggrecan, collagen type II, and collagen type I gene expression (quantitative reverse transcriptase-polymerase chain reaction) and histologically (hematoxylin–eosin staining). Data of MSC/dexa-treated condyles were compared with untreated, dexa-treated, MSC-treated, or normal unlesioned condyles. Results: The ratio between collagen type II expression versus collagen type I expression in MSC/dexa-treated condyles was higher than one, even though the group mean value was not statistically different from that of untreated defects. Histological changes were observed between MSC/dexa-treated and untreated defects mainly in surface regularity and in hyaline matrix abundance. However, International Cartilage Repair Society score analysis did not support robust differences between those groups. Conclusion: Intraarticular administration of dexamethasone after autologous MSC implantation into a preestablished full-thickness chondral defect does not contribute significantly to the regeneration of a tissue with molecular and histological characteristics identical to hyaline cartilage.

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Over 50% of self-reported burnout among Latin American orthopaedic surgeons: A cross-sectional survey on prevalence and risk factors

2024 , VAISMAN BURUCKER, ALEJANDRO ESTEBAN , Rodrigo Guiloff , Martín Contreras , Juan Pablo Casas-cordero , CALVO RODRIGUEZ, RAFAEL , FIGUEROA POBLETE, DAVID HUMBERTO

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Meniscus allograft transplantation: indications, techniques and outcomes

2019 , FIGUEROA BERRIOS, FRANCISCO JAVIER , FIGUEROA POBLETE, DAVID HUMBERTO , CALVO RODRIGUEZ, RAFAEL , Alex Vaisman , João Espregueira-Mendes

New indications for meniscal allograft transplantation (MAT) are being added, but the general expert opinion is that it is still a procedure reserved for symptomatic meniscal loss. Lateral MAT has better clinical outcomes and less failure risk compared to medial MAT. Ideal conditions (low-grade chondral lesions) make MAT a more survivable and successful procedure. Meniscal extrusion after MAT is common and does not seem to alter results. Midterm survivorship of a MAT is reported to be 85–90%, while long-term survivorship decreases to 50–70% depending on chondral status and concomitant procedures. Even if the procedure is a success, there are high possibilities of not being able to resume sports activities. Cite this article: EFORT Open Rev 2019;4:115-120. DOI: 10.1302/2058-5241.4.180052

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Posterolateral corner knee injuries: a narrative review

2021 , FIGUEROA BERRIOS, FRANCISCO JAVIER , FIGUEROA POBLETE, DAVID HUMBERTO , Sven Putnis , Rodrigo Guiloff , Patricio Caro , João Espregueira-Mendes

Limited knowledge of the anatomy and biomechanics of the posterolateral corner (PLC) of the knee, coupled with poor patient outcomes with non-operative management, resulted in the PLC often being labelled as the ‘dark side’ of the knee. In the last two decades, extensive research has resulted in a better understanding of the anatomy and function of the PLC, and has led to the development of anatomic reconstructions that have resulted in improved patient outcomes. Despite considerable attention in the clinical orthopaedic literature (nearly 400 articles published in the last decade), a standardized algorithm for the diagnosis and treatment of the PLC is still lacking, and much controversy remains. Considering the literature review, there is not a reconstruction technique that clearly prevails over the others. As anatomic, biomechanical, and clinical knowledge of PLC injuries continues to progress, finding the balance between re-creating native anatomy and safely performing PLC reconstruction provides a big challenge. Treatment decisions should be made on a case-by-case basis.Cite this article: EFORT Open Rev 2021;6:676-685. DOI: 10.1302/2058-5241.6.200096

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Vancomycin presoaking of hamstring autografts to prevent infection in anterior cruciate ligament reconstruction: a narrative review

2021 , FIGUEROA BERRIOS, FRANCISCO JAVIER , Alex Vaisman , CALVO RODRIGUEZ, RAFAEL , David Figueroa , João Espregueira-Mendes

Hamstring autograft use has been linked to an increased risk of infection after anterior cruciate (ACL) reconstruction compared to other grafts. The absolute reason for this remains unclear, with contamination after harvesting and preparation of the graft being the most accepted hypothesis. Using the rationale that a contaminated graft could be the main factor in postoperative septic arthritis and in an effort to maximize the antibiotic efficacy of the graft, the Vancomycin presoaking technique was developed. It has shown success in decreasing the infection rate in ACL reconstruction. In recent years, an important number of research articles using this protocol have appeared, but the technique is still not widely implemented. Recent literature shows that Vancomycin presoaking of the graft has shown a successful decrease in the infection rate after hamstring autograft ACL reconstruction. It has also shown efficacy decreasing the infection rate in other types of grafts (patellar tendon, quadriceps tendon, allograft) and also in patients with concomitant ligament procedures or open surgeries. Despite the positive effects of Vancomycin presoaking reducing the infection rate after ACL reconstruction, the lack of prospective randomized control trials and the heterogeneity of the different studies mean it is not feasible to recommend Vancomycin presoaking of the graft universally for every ACL reconstruction patient. Cite this article: EFORT Open Rev 2021;6:211-216. DOI: 10.1302/2058-5241.6.200059

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Age influences the efficacy of osteochondral autograft transfer: Promising results for patients under 40

2024 , FIGUEROA BERRIOS, FRANCISCO JAVIER , FIGUEROA POBLETE, DAVID HUMBERTO , CALVO RODRIGUEZ, RAFAEL , Esteban Stocker , Minerva Itriago , NÚÑEZ MARDONES, MARILAURA