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Validation and psychometric evaluation of the Spanish version of Brief Esophageal Dysphagia Questionnaire (BEDQ): Results of a multicentric study

2020 , CISTERNAS, DANIEL , Tiffany Taft , Dustin A. Carlson , GLASINOVIC VERNON, ESTEBAN ANDRES , Hugo Monrroy , Paula Rey , Albis Hani , Andres Ardila‐Hani , Ana Maria Leguizamo , Claudio Bilder , Andres Ditaranto , Amanda Varela , Joaquin Agotegaray , Jose Maria Remes‐Troche , Antonio Ruiz de León , Julio Pérez de la Serna , Ingrid Marin , Jordi Serra

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The Chicago Classification 3.0 Results in More Normal Findings and Fewer Hypotensive Findings With No Difference in Other Diagnoses

2017 , San-Chi Chen , Yee Chao , Muh-Hwa Yang , CISTERNAS, DANIEL

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Updates to the modern diagnosis of GERD: Lyon consensus 2.0

2023 , C Prakash Gyawali , Rena Yadlapati , Ronnie Fass , David Katzka , John Pandolfino , Edoardo Savarino , Daniel Sifrim , Stuart Spechler , Frank Zerbib , Mark R Fox , Shobna Bhatia , Nicola de Bortoli , Yu Kyung Cho , CISTERNAS CAMUS, DANIEL ALEJANDRO , Chien-Lin Chen , Charles Cock , Albis Hani , Jose Maria Remes Troche , Yinglian Xiao , Michael F Vaezi , Sabine Roman

The Lyon Consensus provides conclusive criteria for and against the diagnosis of gastro-oesophageal reflux disease (GERD), and adjunctive metrics that consolidate or refute GERD diagnosis when primary criteria are borderline or inconclusive. An international core and working group was assembled to evaluate research since publication of the original Lyon Consensus, and to vote on statements collaboratively developed to update criteria. The Lyon Consensus 2.0 provides a modern definition of actionable GERD, where evidence from oesophageal testing supports revising, escalating or personalising GERD management for the symptomatic patient. Symptoms that have a high versus low likelihood of relationship to reflux episodes are described. Unproven versus proven GERD define diagnostic strategies and testing options. Patients with no prior GERD evidence (unproven GERD) are studied using prolonged wireless pH monitoring or catheter-based pH or pH-monitoring off antisecretory medication, while patients with conclusive GERD evidence (proven GERD) and persisting symptoms are evaluated using pH-impedance monitoring while on optimised antisecretory therapy. The major changes from the original Lyon Consensus criteria include establishment of Los Angeles grade B oesophagitis as conclusive GERD evidence, description of metrics and thresholds to be used with prolonged wireless pH monitoring, and inclusion of parameters useful in diagnosis of refractory GERD when testing is performed on antisecretory therapy in proven GERD. Criteria that have not performed well in the diagnosis of actionable GERD have been retired. Personalisation of investigation and management to each patient’s unique presentation will optimise GERD diagnosis and management.

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Normal values of esophageal pressure responses to a rapid drink challenge test in healthy subjects: results of a multicenter study

2017 , I. Marin , CISTERNAS, DANIEL , L. Abrao , E. Lemme , C. Bilder , A. Ditaranto , R. Coello , A. Hani , A. M. Leguizamo , A. Meixueiro , J. Remes-Troche , M. A. Zavala , A. Ruiz de León , J. Perez de la Serna , M. A. Valdovinos , J. Serra

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The Brief Esophageal Dysphagia Questionnaire shows better discriminative capacity for clinical and manometric findings than the Eckardt score: Results from a multicenter study

2021 , CISTERNAS, DANIEL , Tiffany Taft , Dustin A. Carlson , Esteban Glasinovic , Hugo Monrroy , Paula Rey , Albis Hani , Andres Ardila‐Hani , Ana Maria Leguizamo , Claudio Bilder , Andres Ditaranto , Amanda Varela , Joaquin Agotegaray , Jose Maria Remes‐Troche , Antonio Ruiz León , Julio Pérez Serna , Ingrid Marin , Jordi Serra

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Are the Chicago 3.0 manometric diagnostics consistent with Chicago 4.0?

2023 , Angélica Tobón , Albis C Hani , Cristiam D Pulgarin , Andres F Ardila , Oscar M Muñoz , Julian A Sierra , Daniel Cisternas

Summary There is little information on the degree of concordance between the results obtained using the Chicago 3.0 (CCv3.0) and Chicago 4.0 (CCv4.0) protocols to interpret high-resolution manometry (HRM) seeking to determine the value provided by the new swallowing maneuvers included in the last protocol. This is a study of diagnostic tests, evaluating concordance by consistency between the results obtained by the CCv3.0 and CCv4.0 protocols, in patients undergoing HRM. Concordance was assessed with the kappa test. Bland–Altman scatter plots, and Lin’s correlation-concordance coefficient (CCC) were used to assess the agreement between IRP measured with swallows in the supine and seated position or with solid swallows. One hundred thirty-two patients were included (65% women, age 53 ± 17 years). The most frequent HRM indication was dysphagia (46.1%). Type I was the most common type of gastroesophageal junction. The most frequent CCv4.0 diagnoses were normal esophageal motility (68.9%), achalasia (15.5%), and ineffective esophageal motility (IEM; 5.3%). The agreement between the results was substantial (Kappa 0.77 ± 0.05), with a total agreement of 87.9%. Diagnostic reclassification occurred in 12.1%, from IEM in CCv3.0 to normal esophageal motility in CCv4.0. Similarly, there was a high level of agreement between the IRP measured in the supine compared to the seated position (CCC0.92) and with solid swallows (CCC0.96). In conclusion, the CCv4.0 protocol presents a high concordance compared to CCv3.0. In the majority of manometric diagnoses there is no reclassification of patients with provocation tests. However, the more restrictive criteria of CCv4.0 achieve a better reclassification of patients with IEM.

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Chicago Classification update (V4.0): Technical review on diagnostic criteria for ineffective esophageal motility and absent contractility

2021 , C. Prakash Gyawali , Frank Zerbib , Shobna Bhatia , CISTERNAS, DANIEL , Enrique Coss‐Adame , Adriana Lazarescu , Daniel Pohl , Rena Yadlapati , Roberto Penagini , John Pandolfino

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Esophagogastric junction morphology and contractile integral on high‐resolution manometry in asymptomatic healthy volunteers: An international multicenter study

2020 , Benjamin D. Rogers , Arvind Rengarajan , Luiz Abrahao , Shobna Bhatia , Serhat Bor , Dustin A. Carlson , CISTERNAS, DANIEL , Sutep Gonlachanvit , Albis Hani , Jamal Hayat , Osamu Kawamura , Yeung Yeh Lee , Ana Maria Leguizamo , Ans Pauwels , Julio Perez de la Serna , Rosa I. Ramos , Jose Maria Remes‐Troche , Sabine Roman , Edoardo Savarino , Jordi Serra , Daniel Sifrim , Salvatore Tolone , Zhiqin Wong , Frank Zerbib , John Pandolfino , C. Prakash Gyawali

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Diagnosticando la enfermedad por reflujo gastroesofágico en 2022: los cómo y los por qué

2022 , CISTERNAS, DANIEL

La enfermedad por reflujo gastroesofágico (ERGE) es muy frecuente en la población, con tasas de prevalencia reportadas de entre 10 y 30%, tanto en Latinoamérica1 como en el resto del mundo.2 Esto, sumado a que el diagnóstico suele requerir estudios costosos y que el manejo implica tratamientos médicos prolongados o cirugía, hacen que la ERGE resulte una enorme carga económica para los países.3 Por otro lado, impacta significativamente en la calidad de vida, habiéndose reportado peor calidad de vida que en casos de enfermedades como la angina de pecho o la insuficiencia cardíaca.4 En este contexto, un abordaje diagnóstico y terapéutico costo-efectivo es imprescindible, en especial en los países subdesarrollados. Los avances tecnológicos de los últimos años han dado lugar a nuevos métodos diagnósticos y nuevas variables para el diagnóstico de la ERGE. Con esto, ha sido necesaria la realización de diversos consensos y la actualización de guías de manejo,5-7 incluido el recientemente desarrollado Consenso Latinoamericano 2022. Entre ellos, se destaca el Consenso de Lyon, que fue publicado en 2018 y es el fruto de años de trabajo de un grupo de connotados expertos mundiales.8 Ha sido tremendamente influyente pues ha redefinido los criterios diagnósticos de la ERGE. Estas definiciones han sido adoptadas, por ejemplo, por el Consenso Latinoamericano y este documento se basa en ellas.

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Novedades acerca de los trastornos motores del esófago tras la reciente clasificación de chicago 4.0

2021 , Claudia Córdoba , Agustina Rodil , CISTERNAS, DANIEL

The Chicago Classification includes esophageal motor disorders diagnosed by high-resolution manometry. Of the manometric patterns, some are always clinically relevant and require treatment (eg, the achalasia), while others may be incidental findings requiring no intervention in which aggressive management would be counterproductive. One of the goals of the new version of the recently published Chicago Classification (CCv4.0) was to distinguish between clinically relevant and non-clinically relevant disorders. With this in mind, the study protocol was modified to include liquid swallows in the supine and sitting positions and provocation tests were standardized. Diagnostic criteria were modified, incorporating the presence of symptoms and the support of complementary studies other than manometry. In this review, we will comment the diagnosis and treatment of esophagogastric junction outlet obstruction and hypomotility disorders based on CCv4.0.