Research Output

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Esophagogastric junction morphology and contractile integral on high‐resolution manometry in asymptomatic healthy volunteers: An international multicenter study

2020 , Benjamin D. Rogers , Arvind Rengarajan , Luiz Abrahao , Shobna Bhatia , Serhat Bor , Dustin A. Carlson , CISTERNAS, DANIEL , Sutep Gonlachanvit , Albis Hani , Jamal Hayat , Osamu Kawamura , Yeung Yeh Lee , Ana Maria Leguizamo , Ans Pauwels , Julio Perez de la Serna , Rosa I. Ramos , Jose Maria Remes‐Troche , Sabine Roman , Edoardo Savarino , Jordi Serra , Daniel Sifrim , Salvatore Tolone , Zhiqin Wong , Frank Zerbib , John Pandolfino , C. Prakash Gyawali

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Breaks in peristaltic integrity predict abnormal esophageal bolus clearance better than contraction vigor or residual pressure at the esophagogastric junction

2021 , Benjamin D. Rogers , CISTERNAS, DANIEL , Arvind Rengarajan , Ingrid Marin , Luiz Abrahao , Albis Hani , Ana M. Lequizamo , José M. Remes‐Troche , Julio Perez de la Serna , Antonio Ruiz de Leon , Frank Zerbib , Jordi Serra , C. Prakash Gyawali

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Updates to the modern diagnosis of GERD: Lyon consensus 2.0

2023 , C Prakash Gyawali , Rena Yadlapati , Ronnie Fass , David Katzka , John Pandolfino , Edoardo Savarino , Daniel Sifrim , Stuart Spechler , Frank Zerbib , Mark R Fox , Shobna Bhatia , Nicola de Bortoli , Yu Kyung Cho , CISTERNAS CAMUS, DANIEL ALEJANDRO , Chien-Lin Chen , Charles Cock , Albis Hani , Jose Maria Remes Troche , Yinglian Xiao , Michael F Vaezi , Sabine Roman

The Lyon Consensus provides conclusive criteria for and against the diagnosis of gastro-oesophageal reflux disease (GERD), and adjunctive metrics that consolidate or refute GERD diagnosis when primary criteria are borderline or inconclusive. An international core and working group was assembled to evaluate research since publication of the original Lyon Consensus, and to vote on statements collaboratively developed to update criteria. The Lyon Consensus 2.0 provides a modern definition of actionable GERD, where evidence from oesophageal testing supports revising, escalating or personalising GERD management for the symptomatic patient. Symptoms that have a high versus low likelihood of relationship to reflux episodes are described. Unproven versus proven GERD define diagnostic strategies and testing options. Patients with no prior GERD evidence (unproven GERD) are studied using prolonged wireless pH monitoring or catheter-based pH or pH-monitoring off antisecretory medication, while patients with conclusive GERD evidence (proven GERD) and persisting symptoms are evaluated using pH-impedance monitoring while on optimised antisecretory therapy. The major changes from the original Lyon Consensus criteria include establishment of Los Angeles grade B oesophagitis as conclusive GERD evidence, description of metrics and thresholds to be used with prolonged wireless pH monitoring, and inclusion of parameters useful in diagnosis of refractory GERD when testing is performed on antisecretory therapy in proven GERD. Criteria that have not performed well in the diagnosis of actionable GERD have been retired. Personalisation of investigation and management to each patient’s unique presentation will optimise GERD diagnosis and management.

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Ineffective esophageal motility and bolus clearance. A study with combined high‐resolution manometry and impedance in asymptomatic controls and patients

2020 , Frank Zerbib , Ingrid Marin , CISTERNAS, DANIEL , Luiz Abrahao , Albis Hani , Ana M. Leguizamo , José M. Remes‐Troche , Julio Perez de la Serna , Antonio Ruiz de Leon , Jordi Serra

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Chicago Classification update (V4.0): Technical review on diagnostic criteria for ineffective esophageal motility and absent contractility

2021 , C. Prakash Gyawali , Frank Zerbib , Shobna Bhatia , CISTERNAS, DANIEL , Enrique Coss‐Adame , Adriana Lazarescu , Daniel Pohl , Rena Yadlapati , Roberto Penagini , John Pandolfino

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Esophageal motility disorders on high‐resolution manometry: Chicago classification version 4.0 ©

2020 , Rena Yadlapati , Peter J. Kahrilas , Mark R. Fox , Albert J. Bredenoord , C. Prakash Gyawali , Sabine Roman , Arash Babaei , Ravinder K. Mittal , Nathalie Rommel , Edoardo Savarino , Daniel Sifrim , André Smout , Michael F. Vaezi , Frank Zerbib , Junichi Akiyama , Shobna Bhatia , Serhat Bor , Dustin A. Carlson , Joan W. Chen , CISTERNAS, DANIEL , Charles Cock , Enrique Coss‐Adame , Nicola de Bortoli , Claudia Defilippi , Ronnie Fass , Uday C. Ghoshal , Sutep Gonlachanvit , Albis Hani , Geoffrey S. Hebbard , Kee Wook Jung , Philip Katz , David A. Katzka , Abraham Khan , Geoffrey Paul Kohn , Adriana Lazarescu , Johannes Lengliner , Sumeet K. Mittal , Taher Omari , Moo In Park , Roberto Penagini , Daniel Pohl , Joel E. Richter , Jordi Serra , Rami Sweis , Jan Tack , Roger P. Tatum , Radu Tutuian , Marcelo F. Vela , Reuben K. Wong , Justin C. Wu , Yinglian Xiao , John E. Pandolfino