SCHUH, CHRISTINA
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SCHUH, CHRISTINA
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cschuh@udd.cl
ORCID
Scopus Author ID
55897063400

Research Output

2024 2024 2023 2023 2022 2022 2021 2021 2020 2020 2019 2019 0.0 0.0 0.5 0.5 1.0 1.0 1.5 1.5 2.0 2.0 2.5 2.5 3.0 3.0

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Microfabrication-based engineering of biomimetic dentin-like constructs to simulate dental aging

2024 , Simon Álvarez , Jose Morales , Paola Tiozzo-Lyon , Pablo Berrios , Valentina Barraza , Kevin Simpson , Andrea Ravasio , Xavier Monforte Vila , Andreas Teuschl-Woller , SCHUH, CHRISTINA , Sebastian Aguayo

Our study aimed to develop a novel in vitro microfabricated biomimetic dentin surface that simulates the complex surface microarchitecture of exposed dentin, as well as age-derived glycation of teeth, for the growth of polymicrobial oral biofilms.

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Modulatory Effect of Glycated Collagen on Oral Streptococcal Nanoadhesion

2020 , SCHUH, CHRISTINA , B. Benso , P.A. Naulin , N.P. Barrera , L. Bozec , S. Aguayo

Biofilm-mediated oral diseases such as dental caries and periodontal disease remain highly prevalent in populations worldwide. Biofilm formation initiates with the attachment of primary colonizers onto surfaces, and in the context of caries, the adhesion of oral streptococci to dentinal collagen is crucial for biofilm progression. It is known that dentinal collagen suffers from glucose-associated crosslinking as a function of aging or disease; however, the effect of collagen crosslinking on the early adhesion and subsequent biofilm formation of relevant oral streptococci remains unknown. Therefore, the aim of this work was to determine the impact of collagen glycation on the initial adhesion of primary colonizers such as Streptococcus mutans UA159 and Streptococcus sanguinis SK 36, as well as its effect on the early stages of streptococcal biofilm formation in vitro. Type I collagen matrices were crosslinked with either glucose or methylglyoxal. Atomic force microscopy nanocharacterization revealed morphologic and mechanical changes within the collagen matrix as a function of crosslinking, such as a significantly increased elastic modulus in crosslinked fibrils. Increased nanoadhesion forces were observed for S. mutans on crosslinked collagen surfaces as compared with the control, and retraction curves obtained for both streptococcal strains demonstrated nanoscale unbinding behavior consistent with bacterial adhesin-substrate coupling. Overall, glucose-crosslinked substrates specifically promoted the initial adhesion, biofilm formation, and insoluble extracellular polysaccharide production of S. mutans, while methylglyoxal treatment reduced biofilm formation for both strains. Changes in the adhesion behavior and biofilm formation of oral streptococci as a function of collagen glycation could help explain the biofilm dysbiosis seen in older people and patients with diabetes. Further studies are necessary to determine the influence of collagen crosslinking on the balance between acidogenic and nonacidogenic streptococci to aid in the development of novel preventive and therapeutic treatment against dental caries in these patients.

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The Role of Schwann Cells in Peripheral Nerve Function, Injury, and Repair

2020-05 , SCHUH, CHRISTINA , DE GREGORIO CONCHA, CRISTIAN ALEJANDRO , Pamina Contreras-kallens

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Royal jelly extracellular vesicles promote wound healing by modulating underlying cellular responses

2023 , Simón Álvarez , Pamina Contreras-Kallens , Sebastian Aguayo , Ramírez Prada, Orlando , Catalina Vallejos , Jorge Ruiz , Eva Carrasco-Gallardo , Stefanie Troncoso-Vera , Bernardo Morales , SCHUH, CHRISTINA

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Aloe vera peel-derived nanovesicles display anti-inflammatory properties and prevent myofibroblast differentiation

2024 , RAMIREZ PRADA, ORLANDO JOSUÉ , Florencia Pomareda , OLIVARES, MARIA BELEN , HUANG, YA LIN , Gabriela Zavala , Javiera Carrasco-Rojas , Simón Alvarez , Camila Leiva-Sabadini , Valeria Hidalgo , Pablo Romo , SANCHEZ JIMÉNEZ, MATÍAS IGNACIO , Ayleen Vargas , Sebastian Aguayo , SCHUH, CHRISTINA , MARTINEZ ARENAS, JESSICA ISABEL

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Motor and sensory Schwann cell phenotype commitment is diminished by extracorporeal shockwave treatment in vitro

2020 , David Hercher , Heinz Redl , Christina M.a.p. Schuh

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Potential Novel Strategies for the Treatment of Dental Pulp-Derived Pain: Pharmacological Approaches and Beyond

2019 , SCHUH, CHRISTINA , Bruna Benso , Sebastian Aguayo

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A Natural deep eutectic solvent as an effective material for dual debridement and antibiofilm effects in chronic wound treatment

2024 , SCHUH, CHRISTINA , EZQUER, EDUARDO FERNANDO , MAMANI FLORES, SIGDE KARINA , CAMPODONICO GALDAMES, PAOLA ROSSANA , Constanza Cárcamo , Fabián Martinez-Gómez , Isabel Aburto , EZQUER, EDUARDO MARCELO , Bernardo Morales , OLIVARES, MARIA BELEN

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Modulation of the biophysical and biochemical properties of collagen by glycation for tissue engineering applications

2023 , Mina Vaez , Meisam Asgari , Liisa Hirvonen , Gorkem Bakir , Emilie Khattignavong , Maya Ezzo , Sebastian Aguayo , SCHUH, CHRISTINA , Kathleen Gough , Laurent Bozec

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Exosomes on the border of species and kingdom intercommunication

2019 , SCHUH, CHRISTINA , Jimena Cuenca , Francisca Alcayaga-Miranda , Maroun Khoury

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