CARVAJAL BENAVIDES, CÉSAR CRISTÓBAL
Thumbnail Image
Preferred name
CARVAJAL BENAVIDES, CÉSAR CRISTÓBAL
Main Affiliation
Email
CRISTOBALCARVAJAL@UDD.CL
ORCID
Scopus Author ID
53163308500

Research Output

2012 2012 0.0 0.0 0.2 0.2 0.4 0.4 0.6 0.6 0.8 0.8 1.0 1.0 1.2 1.2 1.4 1.4 1.6 1.6 1.8 1.8 2.0 2.0

Filters

1
2
2
Reset filters

Settings
Now showing 1 - 2 of 2
No Thumbnail Available
Publication

Surfactant deactivation in a pediatric model induces hypovolemia and fluid shift to the extravascular lung compartment

2012 , FRANCO JAVIER DIAZ RUBIO , Benjamín Erranz , Alejandro Donoso , CARVAJAL BENAVIDES, CÉSAR CRISTÓBAL , Tatiana Salomón , María Torres , Pablo Cruces , Andrew Davidson

Surfactant deficiency is the pivotal abnormality in Neonatal and Acute Respiratory Distress Syndrome. Surfactant deactivation can produce hypoxemia, loss of lung compliance, and pulmonary edema, but its circulatory consequences are less understood. Objective To describe the sequential hemodynamic changes and pulmonary edema formation after surfactant deactivation in piglets. Methods: Surfactant deactivation was induced by tracheal instillation of polysorbate 20 in 15 anesthetized and mechanically ventilated Large White piglets. The hemodynamic consequences of surfactant deactivation were assessed at 30, 120, and 240 min by transpulmonary thermodilution and traditional methods. Results: Surfactant deactivation caused hypoxemia, reduced lung compliance, and progressively increased lung water content (P < 0.01). Early hypovolemia was observed, with reductions of the global end-diastolic volume and stroke volume (P < 0.05). Reduced cardiac output was observed at the end of the study (P < 0.05). Standard monitoring was unable to detect these early preload alterations. Surprisingly, the bronchoalveolar protein content was greatly increased at the end of the study compared with baseline levels (P < 0.01). This finding was inconsistent with the notion that the pulmonary edema induced by surfactant deactivation was exclusively caused by high surface tension. Conclusions: Hypovolemia develops early after surfactant deactivation, in part due to the resulting fluid shift from the intravascular compartment to the lungs

View
No Thumbnail Available
Publication

Diferencia veno-arterial de dióxido de carbono como predictor de gasto cardiaco disminuido en modelo pediátrico experimental

2012 , Franco Díaz , Alejandro Donoso , CARVAJAL BENAVIDES, CÉSAR CRISTÓBAL , Tatiana Salomón , María Torres , Benjamín Erranz , Pablo Cruces

View