CARVAJAL BENAVIDES, CÉSAR CRISTÓBAL
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CARVAJAL BENAVIDES, CÉSAR CRISTÓBAL
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CRISTOBALCARVAJAL@UDD.CL
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53163308500

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Mild hypothermia attenuates lung edema and plasma interleukin-1β in a rat mechanical ventilation-induced lung injury model

2011 , Cruces, Pablo , Ronco, Ricardo , Benjamín Erranz , CONGET MOLINA, PAULETTE ANDREA , CARVAJAL BENAVIDES, CÉSAR CRISTÓBAL , Alejandro Donoso , Franco Díaz

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Diferencia veno-arterial de dióxido de carbono como predictor de gasto cardiaco disminuido en modelo pediátrico experimental

2012 , Franco Díaz , Alejandro Donoso , CARVAJAL BENAVIDES, CÉSAR CRISTÓBAL , Tatiana Salomón , María Torres , Benjamín Erranz , Pablo Cruces

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Surfactant deactivation in a pediatric model induces hypovolemia and fluid shift to the extravascular lung compartment

2012 , FRANCO JAVIER DIAZ RUBIO , Benjamín Erranz , Alejandro Donoso , CARVAJAL BENAVIDES, CÉSAR CRISTÓBAL , Tatiana Salomón , María Torres , Pablo Cruces , Andrew Davidson

Surfactant deficiency is the pivotal abnormality in Neonatal and Acute Respiratory Distress Syndrome. Surfactant deactivation can produce hypoxemia, loss of lung compliance, and pulmonary edema, but its circulatory consequences are less understood. Objective To describe the sequential hemodynamic changes and pulmonary edema formation after surfactant deactivation in piglets. Methods: Surfactant deactivation was induced by tracheal instillation of polysorbate 20 in 15 anesthetized and mechanically ventilated Large White piglets. The hemodynamic consequences of surfactant deactivation were assessed at 30, 120, and 240 min by transpulmonary thermodilution and traditional methods. Results: Surfactant deactivation caused hypoxemia, reduced lung compliance, and progressively increased lung water content (P < 0.01). Early hypovolemia was observed, with reductions of the global end-diastolic volume and stroke volume (P < 0.05). Reduced cardiac output was observed at the end of the study (P < 0.05). Standard monitoring was unable to detect these early preload alterations. Surprisingly, the bronchoalveolar protein content was greatly increased at the end of the study compared with baseline levels (P < 0.01). This finding was inconsistent with the notion that the pulmonary edema induced by surfactant deactivation was exclusively caused by high surface tension. Conclusions: Hypovolemia develops early after surfactant deactivation, in part due to the resulting fluid shift from the intravascular compartment to the lungs

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Angiotensin-converting enzyme insertion/deletion polymorphism is associated with severe hypoxemia in pediatric ARDS

2011 , Pablo Cruces , Franco Díaz , Alonso Puga , Benjamín Erranz , Alejandro Donoso , CARVAJAL BENAVIDES, CÉSAR CRISTÓBAL , Jan Wilhelm , REPETTO LISBOA, MARIA GABRIELA

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Decreased lung compliance increases preload dynamic tests in a pediatric acute lung injury model

2015 , Benjamín Erranz , Franco Díaz , Alejandro Donoso , Tatiana Salomón , CARVAJAL BENAVIDES, CÉSAR CRISTÓBAL , María Fernanda Torres , Pablo Cruces

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