SLACHEVSKY CHONCHOL, ANDREA MARÍA
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SLACHEVSKY CHONCHOL, ANDREA MARÍA
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aslachevsky@med.uchile.cl
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56394322900

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Dataset - Multi-feature computational framework for combined signatures of dementia in underrepresented settings

2022 , SLACHEVSKY CHONCHOL, ANDREA MARÍA

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From Snapshots to Movies: The Association Between Retirement Sequences and Aging Trajectories in Limitations to Perform Activities of Daily Living

2019 , Ariel Azar , Ursula M. Staudinger , Andrea Slachevsky , Ignacio Madero-Cabib , Esteban Calvo

Objective: This study analyzes the dynamic association between retirement sequences and activities of daily living (ADLs) trajectories between ages 60 and 70. Method: Retirement sequences previously established for 7,880 older Americans from the Health and Retirement Study were used in hierarchical linear and propensity score full matching models, analyzing their association with ADL trajectories. Results: Sequences of partial retirement from full- or part-time jobs showed higher baseline and slower decline in ADL than sequences characterized by early labor force disengagement. Discussion: The conventional model in which people completely retire from a full-time job at normative ages and the widely promoted new conventional model of late retirement are both associated with better functioning than early labor force disengagement. But unconventional models, where older adults keep partially engaged with the labor force are also significantly associated with better functioning. These findings call attention to more research on potential avenues to simultaneously promote productive engagement and health later in life.

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The cost of dementia in an unequal country: The case of Chile

2017 , Daniel A. Hojman , Fabian Duarte , Jaime Ruiz-Tagle , Marilu Budnich , Carolina Delgado , Andrea Slachevsky , Stefano Federici

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Dementia in Latin America: Epidemiological Evidence and Implications for Public Policy

2017 , Nilton Custodio , Ana Wheelock , Daniela Thumala , Andrea Slachevsky

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A Multidimensional, Person-Centered Framework for Functional Assessment in Dementia: Insights from the ‘What’, ‘How’, ‘To Whom’, and ‘How Much’ Questions

2024 , SLACHEVSKY CHONCHOL, ANDREA MARÍA , Fabrissio Grandi , Daniela Thumala , Sandra Baez , Hernando Santamaria-García , Maureen Schmitter-Edgecombe , Mario A. Parra

Dementia is a syndrome characterized by cognitive and neuropsychiatric symptoms associated with progressive functional decline (FD). FD is a core diagnostic criterion for dementia, setting the threshold between its prodromal stages and the full-blown disease. The operationalization of FD continues to generate a great deal of controversy. For instance, the threshold of FD for the diagnosis of dementia varies across diagnostic criteria, supporting the need for standardization of this construct. Moreover, there is a need to reconsider how we are measuring FD to set boundaries between normal aging, mild cognitive impairment, and dementia. In this paper, we propose a multidimensional framework that addresses outstanding issues in the assessment of FD: i) What activities of daily living (ADLs) are necessary to sustain an independent living in aging? ii) How to assess FD in individuals with suspected neurocognitive disorders? iii) To whom is the assessment directed? and iv) How much does FD differentiate healthy aging from mild and major neurocognitive disorders? Importantly, the To Whom Question introduces a person-centered approach that regards patients and caregivers as active agents in the assessment process of FD. Thus, once impaired ADLs have been identified, patients can indicate how significant such impairments are for them in daily life. We envisage that this new framework will guide future strategies to enhance functional assessment and treatment of patients with dementia and their caregivers.

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Validation of Picture Free and Cued Selective Reminding Test for Illiteracy in Lima, Peru

2022 , Rosa Montesinos , Jose F. Parodi , Monica M. Diaz , Eder Herrera-Perez , Elizabeth Valeriano-Lorenzo , Ambar Soto , Carolina Delgado , Andrea Slachevsky , Nilton Custodio

Dementia in Latin America is a crucial public health problem. Identifying brief cognitive screening (BCS) tools for the primary care setting is crucial, particularly for illiterate individuals. We evaluated tool performance characteristics and validated the free and total recall sections of the Free and Cued Selective Reminding Test-Picture version (FCSRT-Picture) to discriminate between 63 patients with early Alzheimer’s disease dementia (ADD), 60 amnestic mild cognitive impairment (aMCI) and 64 cognitively healthy Peruvian individuals with illiteracy from an urban area. Clinical, functional, and cognitive assessments were performed. FCSRT-Picture performance was assessed using receiver operating characteristic curve analyses. The mean ± standard deviation scores were 7.7 ± 1.0 in ADD, 11.8 ± 1.6 in aMCI, and 29.5 ± 1.8 in controls. The FCSRT-Picture had better performance characteristics for distinguishing controls from aMCI compared with several other BCS tools, but similar characteristics between controls and early ADD. The FCSRT-Picture is a reliable BCS tool for illiteracy in Peru.

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Aging and Health Policies in Chile: New Agendas for Research

2017 , Daniela Thumala , Brian K. Kennedy , Esteban Calvo , Christian Gonzalez-Billault , Pedro Zitko , Patricia Lillo , Roque Villagra , Agustín Ibáñez , Rodrigo Assar , Maricarmen Andrade , Andrea Slachevsky

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The first genome‐wide association study in the Argentinian and Chilean populations identifies shared genetics with Europeans in Alzheimer's disease

2023 , Maria Carolina Dalmasso , Itziar de Rojas , Natividad Olivar , Carolina Muchnik , Bárbara Angel , Sergio Gloger , Mariana Soledad Sanchez Abalos , María Victoria Chacón , Rafael Aránguiz , Paulina Orellana , Carolina Cuesta , Pablo Galeano , Lorenzo Campanelli , Gisela Vanina Novack , Luis Eduardo Martinez , Nancy Medel , Julieta Lisso , Zulma Sevillano , Nicolás Irureta , Eduardo Miguel Castaño , Laura Montrreal , Michaela Thoenes , Claudia Hanses , Stefanie Heilmann‐Heimbach , Claudia Kairiyama , Inés Mintz , Ivana Villella , Fabiana Rueda , Amanda Romero , Nancy Wukitsevits , Ivana Quiroga , Cristian Gona , Jean‐Charles Lambert , Patricia Solis , Daniel Gustavo Politis , Carlos Alberto Mangone , Christian Gonzalez‐Billault , Mercè Boada , Lluís Tàrraga , SLACHEVSKY CHONCHOL, ANDREA MARÍA , Cecilia Albala , Patricio Fuentes , Silvia Kochen , Luis Ignacio Brusco , Agustín Ruiz , Laura Morelli , Alfredo Ramírez

AbstractINTRODUCTIONGenome‐wide association studies (GWAS) are fundamental for identifying loci associated with diseases. However, they require replication in other ethnicities.METHODSWe performed GWAS on sporadic Alzheimer's disease (AD) including 539 patients and 854 controls from Argentina and Chile. We combined our results with those from the European Alzheimer and Dementia Biobank (EADB) in a meta‐analysis and tested their genetic risk score (GRS) performance in this admixed population.RESULTSWe detected apolipoprotein E ε4 as the single genome‐wide significant signal (odds ratio  = 2.93 [2.37–3.63], P = 2.6 × 10−23). The meta‐analysis with EADB summary statistics revealed four new loci reaching GWAS significance. Functional annotations of these loci implicated endosome/lysosomal function. Finally, the AD‐GRS presented a similar performance in these populations, despite the score diminished when the Native American ancestry rose.DISCUSSIONWe report the first GWAS on AD in a population from South America. It shows shared genetics modulating AD risk between the European and these admixed populations.Highlights This is the first genome‐wide association study on Alzheimer's disease (AD) in a population sample from Argentina and Chile. Trans‐ethnic meta‐analysis reveals four new loci involving lysosomal function in AD. This is the first independent replication for TREM2L, IGH‐gene‐cluster, and ADAM17 loci. A genetic risk score (GRS) developed in Europeans performed well in this population. The higher the Native American ancestry the lower the GRS values.

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Assessing subjective cognitive decline in older adults attending primary health care centers: what question should be asked?

2023 , Matías Molina-Donoso , Teresa Parrao , Céline Meillon , Daniela Thumala , Patricia Lillo , Roque Villagra , Agustín Ibañez , Mauricio Cerda , Pedro Zitko , Hélène Amieva , SLACHEVSKY CHONCHOL, ANDREA MARÍA

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Self-stigma in people living with dementia in Chile: A qualitative exploratory study

2021 , Jean Gajardo , Rubén Alvarado , SLACHEVSKY CHONCHOL, ANDREA MARÍA , Laura N. Gitlin

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