Research Output

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A functional dissociation of the left frontal regions that contribute to single word production tasks

2021 , Justyna O. Ekert , Diego L. Lorca-Puls , GAJARDO VIDAL, ANDREA ELIZABETH , Jennifer T. Crinion , Thomas M.H. Hope , David W. Green , Cathy J. Price

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Better long-term speech outcomes in stroke survivors who received early clinical speech and language therapy: What’s driving recovery?

2021 , Sophie Roberts , Rachel M. Bruce , Louise Lim , Hayley Woodgate , Kate Ledingham , Storm Anderson , Diego L. Lorca-Puls , GAJARDO VIDAL, ANDREA ELIZABETH , Alexander P. Leff , Thomas M. H. Hope , David W. Green , Jennifer T. Crinion , Cathy J. Price

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Right cerebral motor areas that support accurate speech production following damage to cerebellar speech areas

2021 , Sharon Geva , Letitia M. Schneider , Sophie Roberts , Shamima Khan , GAJARDO VIDAL, ANDREA ELIZABETH , Diego L. Lorca-Puls , PLORAS team , Thomas M.H. Hope , David W. Green , Cathy J. Price

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Using transcranial magnetic stimulation of the undamaged brain to identify lesion sites that predict language outcome after stroke

2017 , Diego L. Lorca-Puls , GAJARDO VIDAL, ANDREA ELIZABETH , Mohamed L. Seghier , Alexander P. Leff , Varun Sethi , Susan Prejawa , Thomas M. H. Hope , Joseph T. Devlin , Cathy J. Price

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How distributed processing produces false negatives in voxel-based lesion-deficit analyses

2018 , GAJARDO VIDAL, ANDREA ELIZABETH , Diego L. Lorca-Puls , Jennifer T. Crinion , Jitrachote White , Mohamed L. Seghier , Alex P. Leff , Thomas M.H. Hope , Philipp Ludersdorfer , David W. Green , Howard Bowman , Cathy J. Price

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The impact of sample size on the reproducibility of voxel-based lesion-deficit mappings

2018 , Diego L. Lorca-Puls , GAJARDO VIDAL, ANDREA ELIZABETH , Jitrachote White , Mohamed L. Seghier , Alexander P. Leff , David W. Green , Jenny T. Crinion , Philipp Ludersdorfer , Thomas M.H. Hope , Howard Bowman , Cathy J. Price

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Generalizing post-stroke prognoses from research data to clinical data

2019 , Robert Loughnan , Diego L. Lorca-Puls , GAJARDO VIDAL, ANDREA ELIZABETH , Valeria Espejo-Videla , Céline R. Gillebert , Dante Mantini , Cathy J. Price , Thomas M.H. Hope

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Dissociating the functions of three left posterior superior temporal regions that contribute to speech perception and production

2021 , Justyna O. Ekert , GAJARDO VIDAL, ANDREA ELIZABETH , Diego L. Lorca-Puls , Thomas M.H. Hope , Fred Dick , Jennifer T. Crinion , David W. Green , Cathy J. Price

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The Effect of Right Temporal Lobe Gliomas on Left and Right Hemisphere Neural Processing During Speech Perception and Production Tasks

2022 , Adam Kenji Yamamoto , Ana Sanjuán , Rebecca Pope , Oiwi Parker Jones , Thomas M. H. Hope , Susan Prejawa , Marion Oberhuber , Laura Mancini , Justyna O. Ekert , GAJARDO VIDAL, ANDREA ELIZABETH , Megan Creasey , Tarek A. Yousry , David W. Green , Cathy J. Price

Using fMRI, we investigated how right temporal lobe gliomas affecting the posterior superior temporal sulcus alter neural processing observed during speech perception and production tasks. Behavioural language testing showed that three pre-operative neurosurgical patients with grade 2, grade 3 or grade 4 tumours had the same pattern of mild language impairment in the domains of object naming and written word comprehension. When matching heard words for semantic relatedness (a speech perception task), these patients showed under-activation in the tumour infiltrated right superior temporal lobe compared to 61 neurotypical participants and 16 patients with tumours that preserved the right postero-superior temporal lobe, with enhanced activation within the (tumour-free) contralateral left superior temporal lobe. In contrast, when correctly naming objects (a speech production task), the patients with right postero-superior temporal lobe tumours showed higher activation than both control groups in the same right postero-superior temporal lobe region that was under-activated during auditory semantic matching. The task dependent pattern of under-activation during the auditory speech task and over-activation during object naming was also observed in eight stroke patients with right hemisphere infarcts that affected the right postero-superior temporal lobe compared to eight stroke patients with right hemisphere infarcts that spared it. These task-specific and site-specific cross-pathology effects highlight the importance of the right temporal lobe for language processing and motivate further study of how right temporal lobe tumours affect language performance and neural reorganisation. These findings may have important implications for surgical management of these patients, as knowledge of the regions showing functional reorganisation may help to avoid their inadvertent damage during neurosurgery.