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    Heterogeneous factors influence social cognition across diverse settings in brain health and age-related diseases
    (Springer Science and Business Media LLC, 2024-01-02)
    Sol Fittipaldi
    ;
    Agustina Legaz
    ;
    Marcelo Maito
    ;
    Hernan Hernandez
    ;
    Florencia Altschuler
    Aging diminishes social cognition, and changes in this capacity can indicate brain diseases. However, the relative contribution of age, diagnosis and brain reserve to social cognition, especially among older adults and in global settings, remains unclear when considering other factors. Here, using a computational approach, we combined predictors of social cognition from a diverse sample of 1,063 older adults across nine countries. Emotion recognition, mentalizing and overall social cognition were predicted via support vector regressions from various factors, including diagnosis (subjective cognitive complaints, mild cognitive impairment, Alzheimer’s disease and behavioral variant frontotemporal dementia), demographics, cognition/executive function, brain reserve and motion artifacts from functional magnetic resonance imaging recordings. Higher cognitive/executive functions and education ranked among the top predictors, outweighing age, diagnosis and brain reserve. Network connectivity did not show predictive values. The results challenge traditional interpretations of age-related decline, patient–control differences and brain associations of social cognition, emphasizing the importance of heterogeneous factors.
    Scopus© Citations 31  1
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    Dementia caregiving across Latin America and the Caribbean and brain health diplomacy
    (2021)
    Agustin Ibáñez
    ;
    Stefanie Danielle Pina-Escudero
    ;
    Katherine L Possin
    ;
    Yakeel T Quiroz
    ;
    Fernando Aguzzoli Peres
    Scopus© Citations 49  1
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    The cost of dementia in an unequal country: The case of Chile
    (2017)
    Daniel A. Hojman
    ;
    Fabian Duarte
    ;
    Jaime Ruiz-Tagle
    ;
    Marilu Budnich
    ;
    Carolina Delgado
      1Scopus© Citations 57
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    Towards affordable biomarkers of frontotemporal dementia: A classification study via network's information sharing
    (2017)
    Martin Dottori
    ;
    Lucas Sedeño
    ;
    Miguel Martorell Caro
    ;
    Florencia Alifano
    ;
    Eugenia Hesse
      21Scopus© Citations 50