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    Item type:Publication,
    Safety, Tolerability, Bioavailability, and Biological Activity of Inhaled Interferon-α2b in Healthy Adults: The IN2COVID Phase I Randomized Trial
    (2023)
    Diego Garcia-Huidobro
    ;
    Carolina Iturriaga
    ;
    Guillermo Perez-Mateluna
    ;
    Paula Fajuri
    ;
    Nicolás Severino
    Scopus© Citations 2  1
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    Integrin Alpha E (CD103) Limits Virus-Induced IFN-I Production in Conventional Dendritic Cells
    (2021)
    Vikas Duhan
    ;
    Vishal Khairnar
    ;
    Simo Kitanovski
    ;
    Thamer A. Hamdan
    ;
    KLEIN POSTERNACK, ANDRES DAVID  
    <jats:p>Early and strong production of IFN-I by dendritic cells is important to control vesicular stomatitis virus (VSV), however mechanisms which explain this cell-type specific innate immune activation remain to be defined. Here, using a genome wide association study (GWAS), we identified Integrin alpha-E (<jats:italic>Itgae</jats:italic>, CD103) as a new regulator of antiviral IFN-I production in a mouse model of vesicular stomatitis virus (VSV) infection. CD103 was specifically expressed by splenic conventional dendritic cells (cDCs) and limited IFN-I production in these cells during VSV infection. Mechanistically, CD103 suppressed AKT phosphorylation and mTOR activation in DCs. Deficiency in CD103 accelerated early IFN-I in cDCs and prevented death in VSV infected animals. In conclusion, CD103 participates in regulation of cDC specific IFN-I induction and thereby influences immune activation after VSV infection.</jats:p>
      1Scopus© Citations 4