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    Ecocardiografía Funcional y sus aplicaciones clínicas en Neonatología
    (2021)
    Irene Montoya Claramunt
    ;
    Claudia Sánchez Ramírez
    ;
    Raul Nachar Hidalgo
    ;
    Jorge Torres Torretti
    <jats:p>La Ecocardiografía funcional surge como una herramienta clínica para la valoración del estado hemodinámico del paciente, luego de demostrarse que los métodos clínicos usados tradicionalmente en la unidad de cuidados intensivos neonatales son limitados y muchas veces tardíos. Esto nos permite establecer un diagnóstico hemodinámico más certero y así mejorar la morbimortalidad neonatal ya que permite formular una recomendación basada en la fisiología, que resulta en un plan de tratamiento racional e individualizado. Los escenarios en los cuales se ha visto su utilidad son: transición inadecuada del recién nacido prematuro de muy bajo peso de nacimiento, inestabilidad hemodinámica, valoración del ductus arterioso persitente y su repercusión hemodinámica e hipertensión pulmonar. La presente revisión actualiza la información sobre la utilidad de la ecocardiografía funcional en la unidad de cuidados intensivos neonatales y los escenarios clínicos en donde se recomienda su uso.</jats:p>
      1Scopus© Citations 4
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    Proteomic Analysis of Niemann-Pick Type C Hepatocytes Reveals Potential Therapeutic Targets for Liver Damage
    (2021)
    Elisa Balboa
    ;
    Tamara Marín
    ;
    Juan Esteban Oyarzún
    ;
    Pablo S. Contreras
    ;
    Robert Hardt
    <jats:p>Niemann-Pick type C disease (NPCD) is a lysosomal storage disorder caused by mutations in the NPC1 gene. The most affected tissues are the central nervous system and liver, and while significant efforts have been made to understand its neurological component, the pathophysiology of the liver damage remains unclear. In this study, hepatocytes derived from wild type and Npc1−/− mice were analyzed by mass spectrometry (MS)-based proteomics in conjunction with bioinformatic analysis. We identified 3832 proteins: 416 proteins had a p-value smaller than 0.05, of which 37% (n = 155) were considered differentially expressed proteins (DEPs), 149 of them were considered upregulated, and 6 were considered downregulated. We focused the analysis on pathways related to NPC pathogenic mechanisms, finding that the most significant changes in expression levels occur in proteins that function in the pathways of liver damage, lipid metabolism, and inflammation. Moreover, in the group of DEPs, 30% (n = 47) were identified as lysosomal proteins and 7% (n = 10) were identified as mitochondrial proteins. Importantly, we found that lysosomal DEPs, including CTSB/D/Z, LIPA, DPP7 and GLMP, and mitocondrial DEPs, AKR1B10, and VAT1 had been connected with liver fibrosis, damage, and steatosis in previous studies, validiting our dataset. Our study found potential therapeutic targets for the treatment of liver damage in NPCD.</jats:p>
    Scopus© Citations 9  1