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    Scopus© Citations 9  2
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    Efectos de la injuria renal isquémica aguda en la disfunción extrarenal: Estudio experimental aleatorizado
    (2013)
    CAMILA SALAS A
    ;
    PABLO LILLO A
    ;
    ALEJANDRO PACHECO V
    ;
    TATIANA SALOMÓN S
    ;
    FELIPE LILLO A
    Scopus© Citations 1  1
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    Scopus© Citations 5  1
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    Intensive Care Unit–Acquired Weakness in Patients With Acute Kidney Injury: A Contemporary Review
    (2023)
    J. Pedro Teixeira
    ;
    Kirby P. Mayer
    ;
    Benjamin R. Griffin
    ;
    Naomi George
    ;
    Nathaniel Jenkins
    Scopus© Citations 11  6
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    Critical illness myopathy and trajectory of recovery in acute kidney injury requiring continuous renal replacement therapy: a prospective observational trial protocol
    (2023)
    J Pedro Teixeira
    ;
    Benjamin R Griffin
    ;
    Chaitanya Anil Pal
    ;
    David Felipe Márquez González
    ;
    Nathanial Jenkins
    <jats:sec><jats:title>Introduction</jats:title><jats:p>Acute kidney injury requiring renal replacement therapy (AKI-RRT) is common in the intensive care unit (ICU) and is associated with significant morbidity and mortality. Continuous RRT (CRRT) non-selectively removes large amounts of amino acids from plasma, lowering serum amino acid concentrations and potentially depleting total-body amino acid stores. Therefore, the morbidity and mortality associated with AKI-RRT may be partly mediated through accelerated skeletal muscle atrophy and resulting muscle weakness. However, the impact of AKI-RRT on skeletal muscle mass and function during and following critical illness remains unknown. We hypothesise that patients with AKI-RRT have higher degrees of acute muscle loss than patients without AKI-RRT and that AKI-RRT survivors are less likely to recover muscle mass and function when compared with other ICU survivors.</jats:p></jats:sec><jats:sec><jats:title>Methods and analysis</jats:title><jats:p>This protocol describes a prospective, multicentre, observational trial assessing skeletal muscle size, quality and function in ICU patients with AKI-RRT. We will perform musculoskeletal ultrasound to longitudinally evaluate rectus femoris size and quality at baseline (within 48 hours of CRRT initiation), day 3, day 7 or at ICU discharge, at hospital discharge, and 1–3 months postdischarge. Additional skeletal muscle and physical function tests will be performed at hospital discharge and postdischarge follow-up. We will analyse the effect of AKI-RRT by comparing the findings in enrolled subjects to historical controls of critically ill patients without AKI-RRT using multivariable modelling.</jats:p></jats:sec><jats:sec><jats:title>Ethics and dissemination</jats:title><jats:p>We anticipate our study will reveal that AKI-RRT is associated with greater degrees of muscle loss and dysfunction along with impaired postdischarge recovery of physical function. These findings could impact the in-hospital and postdischarge treatment plan for these patients to include focused attention on muscle strength and function. We intend to disseminate findings to participants, healthcare professionals, the public and other relevant groups via conference presentation and publication without any publication restrictions.</jats:p></jats:sec><jats:sec><jats:title>Trial registration number</jats:title><jats:p><jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="clintrialgov" xlink:href="NCT05287204">NCT05287204</jats:ext-link>.</jats:p></jats:sec>
      4Scopus© Citations 5
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      17  1Scopus© Citations 8
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    Prevention of Crush Syndrome through Aggressive Early Resuscitation: Clinical Case in a Buried Worker
    (2016)
    Alvaro Mardones
    ;
    Pablo Arellano
    ;
    Carlos Rojas
    ;
    Rodrigo Gutierrez
    ;
    Nicolas Oliver
    <jats:title>Abstract</jats:title><jats:sec id="S1049023X16000327_abs1" sec-type="intro"><jats:title>Introduction</jats:title><jats:p>Crush syndrome, of which little is known, occurs as a result of compression injury to the muscles. This syndrome is characterized by systemic manifestations such as acute kidney injury (AKI), hypovolemic shock, and hydroelectrolytic variations. This pathology presents high morbidity and mortality if not managed aggressively by prehospital care.</jats:p></jats:sec><jats:sec id="S1049023X16000327_abs2" sec-type="general"><jats:title>Clinical Case</jats:title><jats:p>A 40-year-old worker was rescued after being buried underground in a ditch for 19 hours. The patient was administered early resuscitation with isotonic solutions and monitored during the entire rescue operation. Despite having increased plasma levels of total creatine kinase (CK), the patient did not develop AKI or hydroelectrolytic variations.</jats:p></jats:sec><jats:sec id="S1049023X16000327_abs3" sec-type="conclusion"><jats:title>Conclusion</jats:title><jats:p>Aggressive early management with isotonic solutions before hospital arrival is an effective option for nephron-protection and prevention of crush syndrome.</jats:p><jats:p><jats:mixed-citation id="S1049023X16000327_refa1" publication-type="other"><jats:name name-style="western"><jats:surname>Mardones</jats:surname><jats:given-names>A</jats:given-names></jats:name>, <jats:name name-style="western"><jats:surname>Arellano</jats:surname><jats:given-names>P</jats:given-names></jats:name>, <jats:name name-style="western"><jats:surname>Rojas</jats:surname><jats:given-names>C</jats:given-names></jats:name>, <jats:name name-style="western"><jats:surname>Gutierrez</jats:surname><jats:given-names>R</jats:given-names></jats:name>, <jats:name name-style="western"><jats:surname>Oliver</jats:surname><jats:given-names>N</jats:given-names></jats:name>, <jats:name name-style="western"><jats:surname>Borgna</jats:surname><jats:given-names>V</jats:given-names></jats:name>. <jats:article-title>Prevention of crush syndrome through aggressive early resuscitation: clinical case in a buried worker</jats:article-title>. <jats:source>Prehosp Disaster Med</jats:source>. <jats:year>2016</jats:year>;<jats:volume>31</jats:volume>(<jats:issue>3</jats:issue>):<jats:fpage>340</jats:fpage>–<jats:lpage>342</jats:lpage>.</jats:mixed-citation></jats:p></jats:sec>
      7Scopus© Citations 5