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Author: search.filters.author.Roque Sáenz

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    Escurrimiento oleoso anaranjado o «keriorrea», («orange oily anal leakage»): una nueva enfermedad ligada a cambios de hábito alimentario
    (2012)
    Ignacio Robles
    ;
    Jose Manuel Vásquez
    ;
    Rodrigo Loehnert
    ;
    Alberto Espino
    ;
    Francisco Biel
      7Scopus© Citations 5
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    Escurrimiento oleoso anaranjado o «keriorrea», («orange oily anal leakage»): una nueva enfermedad ligada a cambios de hábito alimentario
    (2012)
    Ignacio Robles
    ;
    Jose Manuel Vásquez
    ;
    Rodrigo Loehnert
    ;
    Alberto Espino
    ;
    Francisco Biel
    <jats:p> Given the enormous estimated burden of respiratory virus infections worldwide, a substantial number of research priorities exist in order to better understand their epidemiology, pathogenesis, prevention and clinical management across different populations and resource settings. New therapeutics and specific vaccines for noninfluenza respiratory virus infections could provide enormous benefits in reducing the morbidity and mortality associated with these frequent infections and provide the foundation for responding to newly emerging threats. The BRaVe Initiative is a new WHO-led effort to catalyze multidisciplinary research on strategies to prevent and treat medically important respiratory virus infections with the goal of timely integration of scientific advances and technical innovations into public health practice. </jats:p>
      6Scopus© Citations 5
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    WGO Guideline—Endoscope Disinfection Update
    (2022)
    Tony Speer
    ;
    Michelle Alfa
    ;
    Dianne Jones
    ;
    Karen Vickery
    ;
    Helen Griffiths
    Scopus© Citations 10
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    An efficient strategy for evaluating new non-invasive screening tests for colorectal cancer: the guiding principles
    (2023)
    Robert S Bresalier
    ;
    Carlo Senore
    ;
    Graeme P Young
    ;
    James Allison
    ;
    Robert Benamouzig
    <jats:sec><jats:title>Objective</jats:title><jats:p>New screening tests for colorectal cancer (CRC) are rapidly emerging. Conducting trials with mortality reduction as the end point supporting their adoption is challenging. We re-examined the principles underlying evaluation of new non-invasive tests in view of technological developments and identification of new biomarkers.</jats:p></jats:sec><jats:sec><jats:title>Design</jats:title><jats:p>A formal consensus approach involving a multidisciplinary expert panel revised eight previously established principles.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Twelve newly stated principles emerged. Effectiveness of a new test can be evaluated by comparison with a proven comparator non-invasive test. The faecal immunochemical test is now considered the appropriate comparator, while colonoscopy remains the diagnostic standard. For a new test to be able to meet differing screening goals and regulatory requirements, flexibility to adjust its positivity threshold is desirable. A rigorous and efficient four-phased approach is proposed, commencing with small studies assessing the test’s ability to discriminate between CRC and non-cancer states (<jats:italic>phase I</jats:italic>), followed by prospective estimation of accuracy across the continuum of neoplastic lesions in neoplasia-enriched populations (<jats:italic>phase II</jats:italic>). If these show promise, a provisional test positivity threshold is set before evaluation in typical screening populations.<jats:italic>Phase III</jats:italic>prospective studies determine single round intention-to-screen programme outcomes and confirm the test positivity threshold.<jats:italic>Phase IV</jats:italic>studies involve evaluation over repeated screening rounds with monitoring for missed lesions. Phases III and IV findings will provide the real-world data required to model test impact on CRC mortality and incidence.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>New non-invasive tests can be efficiently evaluated by a rigorous phased comparative approach, generating data from unbiased populations that inform predictions of their health impact.</jats:p></jats:sec>
      8Scopus© Citations 37
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    Uniting the Global Gastroenterology Community to Meet the Challenge of Climate Change and Nonrecyclable Waste
    (2021)
    Desmond Leddin
    ;
    M. Bishr Omary
    ;
    Andrew Veitch
    ;
    Geoffrey Metz
    ;
    Naima Amrani
      1Scopus© Citations 10
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    Minimizing the Risks of Simethicone in Endoscope Reprocessing
    (2022)
    Tony Speer
    ;
    Karen Vickery
    ;
    Michelle Alfa
    ;
    Roque Sáenz
      4Scopus© Citations 6
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    Uniting the Global Gastroenterology Community to Meet the Challenge of Climate Change and Non-Recyclable Waste
    (2021)
    Desmond Leddin
    ;
    M. Bishr Omary
    ;
    Andrew Veitch
    ;
    Geoffrey Metz
    ;
    Naima Amrani
      29Scopus© Citations 21
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      1