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Author: search.filters.author.Pedro Zitko

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    Loss in Old Age: The Role of Sociodemographic and Cognitive Factors
    (SAGE Publications, 2025-12-08)
    Daniela Thumala-Dockendorff
    ;
    Marcelo Arnold-Cathalifaud
    ;
    Teresa Parrao
    ;
    Rodrigo Assar
    ;
    Roque Villagra
    <jats:p>Understanding how different types of losses accumulate and are perceived in later life is essential for designing effective mental health interventions. This study examined the types, co-occurrence, and perceived intensity of losses experienced by older adults in Chile, where no prior research has systematically addressed this phenomenon. We also analyzed how sociodemographic variables (sex, education, income, and social network characteristics) and cognitive impairment without dementia relate to the experience of loss. One hundred ninety-four community-dwelling older adults in Chile completed the Scale of Losses in Old Age (SLO), the Mini-Mental State Examination (MMSE), and a sociodemographic questionnaire. Results confirmed the accumulation of diverse, mostly moderate-intensity losses, particularly the death of significant others and declines in health and physical capacity. Losses tended to co-occur and were significantly associated with socioeconomic disadvantage and dissatisfaction with close relationships, especially with children. Cognitive impairment was associated with greater intensity of specific losses but did not independently predict overall burden. These findings highlight the importance of considering the number and types of losses, their subjective appraisal, and the structural and relational conditions that shape their psychological impact. The study offers a novel framework for assessing loss in old age and provides context-sensitive evidence to inform policy and intervention design.</jats:p>
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    The “when” matters: Evidence from memory markers in the clinical continuum of Alzheimer’s disease.
    (2023)
    Gonzalo Forno
    ;
    Mario A. Parra
    ;
    Daniela Thumala
    ;
    Roque Villagra
    ;
    Mauricio Cerda
      6Scopus© Citations 5
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    Assessing subjective cognitive decline in older adults attending primary health care centers: what question should be asked?
    (2023)
    Matías Molina-Donoso
    ;
    Teresa Parrao
    ;
    Céline Meillon
    ;
    Daniela Thumala
    ;
    Patricia Lillo
    Scopus© Citations 1  1
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    Scopus© Citations 2  2
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    Scopus© Citations 17  1
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      4
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    Population attributable fraction of modifiable risk factors for dementia in Chile
    (2022)
    Rodrigo C. Vergara
    ;
    Pedro Zitko
    ;
    Andrea Slachevsky  
    ;
    Consuelo San Martin
    ;
    Carolina Delgado
      20Scopus© Citations 25
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    GERO Cohort Protocol, Chile, 2017–2022: Community-based Cohort of Functional Decline in Subjective Cognitive Complaint elderly
    (2020)
    Andrea Slachevsky  
    ;
    Pedro Zitko
    ;
    David Martínez-Pernía
    ;
    Gonzalo Forno
    ;
    Felipe A. Court
    <jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>With the global population aging and life expectancy increasing, dementia has turned a priority in the health care system. In Chile, dementia is one of the most important causes of disability in the elderly and the most rapidly growing cause of death in the last 20 years. Cognitive complaint is considered a predictor for cognitive and functional decline, incident mild cognitive impairment, and incident dementia. The GERO cohort is the Chilean core clinical project of the Geroscience Center for Brain Health and Metabolism (GERO). The objective of the GERO cohort is to analyze the rate of functional decline and progression to clinical dementia and their associated risk factors in a community-dwelling elderly with subjective cognitive complaint, through a population-based study. We also aim to undertake clinical research on brain ageing and dementia disorders, to create data and biobanks with the appropriate infrastructure to conduct other studies and facilitate to the national and international scientific community access to the data and samples for research.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>The GERO cohort aims the recruitment of 300 elderly subjects (&gt; 70 years) from Santiago (Chile), following them up for at least 3 years. Eligible people are adults not diagnosed with dementia with subjective cognitive complaint, which are reported either by the participant, a proxy or both. Participants are identified through a household census. The protocol for evaluation is based on a multidimensional approach including socio-demographic, biomedical, psychosocial, neuropsychological, neuropsychiatric and motor assessments. Neuroimaging, blood and stool samples are also obtained. This multidimensional evaluation is carried out in a baseline and 2 follow-ups assessments, at 18 and 36 months. In addition, in months 6, 12, 24, and 30, a telephone interview is performed in order to keep contact with the participants and to assess general well-being.</jats:p></jats:sec><jats:sec><jats:title>Discussion</jats:title><jats:p>Our work will allow us to determine multidimensional risks factors associated with functional decline and conversion to dementia in elderly with subjective cognitive complain. The aim of our GERO group is to establish the capacity to foster cutting edge and multidisciplinary research on aging in Chile including basic and clinical research.</jats:p></jats:sec><jats:sec><jats:title>Trial registration</jats:title><jats:p><jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="https://clinicaltrials.gov/ct2/show/NCT04265482">NCT04265482</jats:ext-link>in ClinicalTrials.gov. Registration Date: February 11, 2020. Retrospectively Registered.</jats:p></jats:sec>
    Scopus© Citations 13  2
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    Aging and Health Policies in Chile: New Agendas for Research
    (2017)
    Daniela Thumala
    ;
    Brian K. Kennedy
    ;
    Esteban Calvo
    ;
    Christian Gonzalez-Billault
    ;
    Pedro Zitko
      20Scopus© Citations 52
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    Priority setting for mental health research in Chile
    (2017)
    Pedro Zitko
    ;
    Francesca Borghero
    ;
    Cynthia Zavala
    ;
    Niina Markkula  
    ;
    Emilio Santelices
    Scopus© Citations 8  7