Universidad del Desarrollo

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Can We Really Expect to Predict Patient Outcomes Using the Lung Ultrasound Aeration Score Pattern?
(SAGE Publications, 2025-12-01)
Diana Adrião
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Javiera Aguilera
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Pablo Mercado
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Francesco Mojoli
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Silvia Mongodi
2
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Association of Ventilatory Ratio with Acute Cor Pulmonale and Mortality in COVID-19 ARDS: A Cohort Study
(SAGE Publications, 2025-09-08)
Martín H. Benites
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Romina Battiato
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Pablo Mercado
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Ronald Pairumani
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Juan Nicolás Medel
Purpose : An elevated ventilatory ratio (VR) and acute cor pulmonale (ACP) are associated with mortality in ARDS patients. The primary aim of this study was to assess the association between VR and ACP in patients with COVID-19-related ARDS (C-ARDS). The secondary objectives were to analyze the association between VR and ICU mortality, describe VR temporal behavior in survivors and non-survivors, and evaluate the association between VR and pulmonary embolism. Materials and Methods : We studied a cohort of patients with C-ARDS. The VR was calculated using a validated formula. Echocardiography was used to diagnose ACP, and CT pulmonary angiography was performed to identify PE. To evaluate the associations between VR and ACP, mortality, and PE, a generalized logistic regression model was used. Results : Of the 140 subjects, 60 (43%) had a VR < 2, while 80 (57%) had a VR >= 2. Patients with a VR >= 2 had a higher risk of developing ACP than those with a VR <2 (Odds Ratio (OR), 3.77; 95% CI: 1.30 - 8.72). The ICU mortality rate was 29%. Of the 40 patients who died, 30 (75%) had a VR >= 2. Mortality was significantly associated with VR >= 2 and driving pressure >= 15 cm H2O. In non-survivor patients with a VR < 2 at ICU admission, a significant increase in VR was observed over the 7-day observation period. No significant association was observed between PE and VR (p = .118). Conclusion : Elevated VR was associated with ACP in patients with C-ARDS. VR >= 2 combined with driving pressure >= 15 cm H2O significantly improved the ability to identify patients at risk for ACP. Additionally, at ICU admission, elevated VR values and initially low values that increased over the first week were associated with higher ICU mortality.
Scopus© Citations 1 1
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The brain: an overloaded but overlooked organ. Author’s reply
(Springer Science and Business Media LLC, 2025-06-03)
Silvia Mongodi
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Javiera Aguilera
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Pablo Mercado
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Diana Adriao
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Luigi Camporota
1
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Lung recruitment maneuver improves right and left ventricular function in patients with acute respiratory distress syndrome
(Springer Science and Business Media LLC, 2025-05-31)
Alexis Lambour
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Yoann Zerbib
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Pablo Mercado
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Loay Kontar
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Bertrand De Cagny
1
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Mitral annular plane systolic excursion for assessing left ventricular systolic dysfunction in patients with septic shock
(2023)
Clément Brault
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Yoann Zerbib
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Pablo Mercado
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Momar Diouf
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Audrey Michaud
8Scopus© Citations 5
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Cardiac function in critically ill patients with severe COVID: A prospective cross-sectional study in mechanically ventilated patients
(2022)
Emilio Daniel Valenzuela
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Pablo Mercado
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Ronald Pairumani
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Juan Nicolás Medel
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Edward Petruska
Scopus© Citations 6 64
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Critical care echocardiography in prone position patients during COVID-19 pandemic: a feasibility study
(2022)
Diego Ugalde
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Juan Nicolas Medel
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Pablo Mercado
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Ronald Pairumani
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Daniela Eisen
Scopus© Citations 5 1
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Extravascular lung water levels are associated with mortality: a systematic review and meta-analysis
(2022)
Francesco Gavelli
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Rui Shi
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Jean-Louis Teboul
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Danila Azzolina
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Pablo Mercado
<jats:title>Abstract</jats:title><jats:sec> <jats:title>Background</jats:title> <jats:p>The prognostic value of extravascular lung water (EVLW) measured by transpulmonary thermodilution (TPTD) in critically ill patients is debated. We performed a systematic review and meta-analysis of studies assessing the effects of TPTD-estimated EVLW on mortality in critically ill patients. </jats:p> </jats:sec><jats:sec> <jats:title>Methods</jats:title> <jats:p>Cohort studies published in English from Embase, MEDLINE, and the Cochrane Database of Systematic Reviews from 1960 to 1 June 2021 were systematically searched. From eligible studies, the values of the odds ratio (OR) of EVLW as a risk factor for mortality, and the value of EVLW in survivors and non-survivors were extracted. Pooled OR were calculated from available studies. Mean differences and standard deviation of the EVLW between survivors and non-survivors were calculated. A random effects model was computed on the weighted mean differences across the two groups to estimate the pooled size effect. Subgroup analyses were performed to explore the possible sources of heterogeneity.</jats:p> </jats:sec><jats:sec> <jats:title>Results</jats:title> <jats:p>Of the 18 studies included (1296 patients), OR could be extracted from 11 studies including 905 patients (464 survivors vs. 441 non-survivors), and 17 studies reported EVLW values of survivors and non-survivors, including 1246 patients (680 survivors vs. 566 non-survivors). The pooled OR of EVLW for mortality from eleven studies was 1.69 (95% confidence interval (CI) [1.22; 2.34], <jats:italic>p</jats:italic> < 0.0015). EVLW was significantly lower in survivors than non-survivors, with a mean difference of −4.97 mL/kg (95% CI [−6.54; −3.41], <jats:italic>p</jats:italic> < 0.001). The results regarding OR and mean differences were consistent in subgroup analyses.</jats:p> </jats:sec><jats:sec> <jats:title>Conclusions</jats:title> <jats:p>The value of EVLW measured by TPTD is associated with mortality in critically ill patients and is significantly higher in non-survivors than in survivors. This finding may also be interpreted as an indirect confirmation of the reliability of TPTD for estimating EVLW at the bedside. Nevertheless, our results should be considered cautiously due to the high risk of bias of many studies included in the meta-analysis and the low rating of certainty of evidence.</jats:p> <jats:p><jats:italic>Trial registration</jats:italic> the study protocol was prospectively registered on PROSPERO: CRD42019126985.</jats:p> </jats:sec>
Scopus© Citations 27 1
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Doppler Echocardiographic Indices Are Specific But Not Sensitive to Predict Pulmonary Artery Occlusion Pressure in Critically Ill Patients Under Mechanical Ventilation
(2020)
Pablo Mercado
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Julien Maizel
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Julien Marc
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Christophe Beyls
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Yoann Zerbib
1Scopus© Citations 14
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Inferior Vena Cava Thrombosis Related to Hypothermia Catheter: Report of 20 Consecutive Cases
(2015)
ANDRES MATIAS RECCIUS MEZA
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Pablo Mercado
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Patricio Vargas
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Claudio Canals
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Jose Montes
Scopus© Citations 11 1

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