CRIS

Permanent URI for this communityhttps://investigadores.udd.cl/handle/123456789/1

Browse

Settings

Author: search.filters.author.Michael HornbergerStart date: 2020

Search Results

Now showing 1 - 5 of 5
  • Loading...
    Thumbnail Image
    Some of the metrics are blocked by your 
    consent settings
    Item type:Publication,
    Activities of daily living and their neural correlates across the Alzheimer's disease continuum: Evidence from a Latin American cohort
    (Wiley, 2026-04-29)
    Patricio Riquelme
    ;
    Gonzalo Forno
    ;
    Joaquín Migeot
    ;
    Rodrigo Henríquez
    ;
    Patricia Lillo
    <jats:title>Abstract</jats:title> <jats:sec> <jats:title>INTRODUCTION</jats:title> <jats:p>Functional decline in activities of daily living (ADL)—advanced (AADL), instrumental (IADL), and basic (BADL)—is a hallmark of Alzheimer's disease (AD). However, integrated clinical–neuroanatomical evidence on progression across the AD continuum remains limited, particularly in Latin American populations.</jats:p> </jats:sec> <jats:sec> <jats:title>METHODS</jats:title> <jats:p>We studied 138 older adults with subjective cognitive complaints (SCCs), mild cognitive impairment (MCI), and Alzheimer's disease dementia (ADD). ADL domains were assessed using the Technology‐Activities of Daily Living Questionnaire. Structural magnetic resonance imaging data were analyzed using voxel‐based morphometry (VBM) to identify gray matter (GM) correlates of ADL performance.</jats:p> </jats:sec> <jats:sec> <jats:title>RESULTS</jats:title> <jats:p>A hierarchical decline from AADL to IADL to BADL differentiated clinical stages. SCC and MCI differed mainly in AADL performance, whereas ADD showed decline across all domains. VBM revealed GM correlates consistent with this hierarchy, with distinct but partially overlapping substrates for each ADL domain.</jats:p> </jats:sec> <jats:sec> <jats:title>DISCUSSION</jats:title> <jats:p>These findings underscore a diagnostically informative and anatomically organized progression of ADL decline.</jats:p> </jats:sec>
    Scopus© Citations 1  3
  • Loading...
    Thumbnail Image
    Some of the metrics are blocked by your 
    consent settings
    Item type:Publication,
    Impact of cardiometabolic factors and AD plasma biomarkers on white matter hyperintensities volume in individuals with cognitive complaints from the global south
    (Elsevier BV, 2026-02)
    Patricio Riquelme-Contreras
    ;
    Fernando Henriquez
    ;
    Cecilia Gonzalez-Campo
    ;
    Florencia Altschuler
    ;
    Matías Fraile-Vazquez
      2
  • Loading...
    Thumbnail Image
    Some of the metrics are blocked by your 
    consent settings
    Item type:Publication,
    Heterogeneous factors influence social cognition across diverse settings in brain health and age-related diseases
    (Springer Science and Business Media LLC, 2024-01-02)
    Sol Fittipaldi
    ;
    Agustina Legaz
    ;
    Marcelo Maito
    ;
    Hernan Hernandez
    ;
    Florencia Altschuler
    Aging diminishes social cognition, and changes in this capacity can indicate brain diseases. However, the relative contribution of age, diagnosis and brain reserve to social cognition, especially among older adults and in global settings, remains unclear when considering other factors. Here, using a computational approach, we combined predictors of social cognition from a diverse sample of 1,063 older adults across nine countries. Emotion recognition, mentalizing and overall social cognition were predicted via support vector regressions from various factors, including diagnosis (subjective cognitive complaints, mild cognitive impairment, Alzheimer’s disease and behavioral variant frontotemporal dementia), demographics, cognition/executive function, brain reserve and motion artifacts from functional magnetic resonance imaging recordings. Higher cognitive/executive functions and education ranked among the top predictors, outweighing age, diagnosis and brain reserve. Network connectivity did not show predictive values. The results challenge traditional interpretations of age-related decline, patient–control differences and brain associations of social cognition, emphasizing the importance of heterogeneous factors.
    Scopus© Citations 31  1
  • Loading...
    Thumbnail Image
    Some of the metrics are blocked by your 
    consent settings
    Item type:Publication,
    Does culture shape our understanding of others’ thoughts and emotions? An investigation across 12 countries.
    (2022)
    François Quesque
    ;
    Antoine Coutrot
    ;
    Sharon Cox
    ;
    Leonardo Cruz de Souza
    ;
    Sandra Baez
      24Scopus© Citations 35
  • Loading...
    Thumbnail Image
    Some of the metrics are blocked by your 
    consent settings
    Item type:Publication,
      29Scopus© Citations 73