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Author: search.filters.author.Kirby P. MayerSubject: search.filters.subject.critical illness

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    Concurrent nutrition and physical rehabilitation interventions for patients with critical illness
    (Ovid Technologies (Wolters Kluwer Health), 2024-12-16)
    GONZALEZ SEGUEL, FELIPE ANDRES  
    ;
    Kirby P. Mayer
    ;
    Renee D. Stapleton
    The effects of either physical rehabilitation or nutrition on outcomes in patients with critical illness are variable and remain unclear. The potential for the combination of exercise and nutritional delivered concurrently to provide benefit is provocative, but data are only emerging. Herein, we provide a summary of evidence from 2023 and 2024 on combined physical rehabilitation and nutrition during and following critical illness. Recent findings While latest trials on physical rehabilitation alone reported conflicting findings, recent nutrition trials found no difference between higher and lower protein delivery and even suggested harm in patients with acute kidney injury. In 2023 and 2024, we identified four studies (one randomized controlled trial) combining physical rehabilitation and nutrition (mainly protein supplementation) within the ICU setting. Overall, these suggested benefits, including reduction of muscle size loss, ICU acquired weakness, delirium, and improved mobility levels, although these benefits did not extend to mortality and hospital length of stay. No recent trials combining physical rehabilitation and nutrition for patients after ICU were identified.</jats:p>
    Scopus© Citations 6  1
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    Muscle Dysfunction and Physical Recovery After Critical Illness
    (SAGE Publications, 2025-02-04)
    Matthew F. Mart
    ;
    Joshua I. Gordon
    ;
    GONZALEZ SEGUEL, FELIPE ANDRES  
    ;
    Kirby P. Mayer
    ;
    Nathan Brummel
    During critical illness, patients experience significant and rapid onsets of muscle wasting and dysfunction with loss of strength, mass, and power. These deficits often persist long after the ICU, leading to impairments in physical function including reduced exercise capacity and increased frailty and disability. While there are numerous studies describing the epidemiology of impaired muscle and physical function in the ICU, there are significantly fewer data investigating mechanisms of prolonged and persistent impairments in ICU survivors. Additionally, while several potential clinical risk factors associated with poor physical recovery have been identified, there remains a dearth of interventions that have effectively improved outcomes long-term among survivors. In this article, we aim to provide a thorough, evidence-based review of the current state of knowledge regarding muscle dysfunction and physical function after critical illness with a focus on post-ICU and post-hospitalization phase of recovery.
    Scopus© Citations 14  2
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    Intensive Care Unit–Acquired Weakness in Patients With Acute Kidney Injury: A Contemporary Review
    (2023)
    J. Pedro Teixeira
    ;
    Kirby P. Mayer
    ;
    Benjamin R. Griffin
    ;
    Naomi George
    ;
    Nathaniel Jenkins
    Scopus© Citations 11  6