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Author: search.filters.author.Julia-Tatjana Maul

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    Dermatologist-like explainable AI enhances trust and confidence in diagnosing melanoma
    (2024)
    Tirtha Chanda
    ;
    Katja Hauser
    ;
    Sarah Hobelsberger
    ;
    Tabea-Clara Bucher
    ;
    Carina Nogueira Garcia
    Artificial intelligence (AI) systems have been shown to help dermatologists diagnose melanoma more accurately, however they lack transparency, hindering user acceptance. Explainable AI (XAI) methods can help to increase transparency, yet often lack precise, domain-specific explanations. Moreover, the impact of XAI methods on dermatologists’ decisions has not yet been evaluated. Building upon previous research, we introduce an XAI system that provides precise and domain-specific explanations alongside its differential diagnoses of melanomas and nevi. Through a three-phase study, we assess its impact on dermatologists’ diagnostic accuracy, diagnostic confidence, and trust in the XAI-support. Our results show strong alignment between XAI and dermatologist explanations. We also show that dermatologists’ confidence in their diagnoses, and their trust in the support system significantly increase with XAI compared to conventional AI. This study highlights dermatologists’ willingness to adopt such XAI systems, promoting future use in the clinic.
      6Scopus© Citations 64
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    Comorbidities in Chilean patients with psoriasis: a Global Healthcare Study on Psoriasis
    (2022)
    Fernando Valenzuela
    ;
    Claudia De La Cruz
    ;
    Cristóbal Lecaros
    ;
    Javier Fernández
    ;
    Gonzalo Hevia
    <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background</jats:title> <jats:p>Psoriasis is a chronic inflammatory skin disease associated with several important medical comorbidities. There are scant data available on the comorbidities of patients with psoriasis in South America.</jats:p> </jats:sec> <jats:sec> <jats:title>Aim</jats:title> <jats:p>To examine the comorbidity profile of adult patients with psoriasis in Chile and its association with severity of psoriasis.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>This was a multicentre, cross-sectional study involving 16 hospitals and clinics in Chile, which used a 48-item questionnaire to study clinician- and patient-reported outcomes and comorbidities. Inferential analyses were performed by psoriasis severity, using Fisher exact test, Student t-test and multivariable logistic regression.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>In total, 598 adult patients with psoriasis were included (51.1% male; mean age 49.2 ± 15.1 years); 48.5% mild and 51.4% moderate to severe; Psoriasis Area and Severity Index 11.6 ± 11.5; body surface area 14.7 ± 18.2%. Plaque psoriasis was the most common phenotype (90.2%), followed by guttate (13.4%). Psoriatic arthritis occurred in 27.3% of patients. Comorbidities were reported in 60.2% of all patients with psoriasis. Frequent concomitant diseases were obesity (25.3%), hypertension (24.3%), Type 2 diabetes mellitus (T2DM) (18.7%), dyslipidaemia (17.4%), metabolic syndrome (16.7%) and depression (14.4%). After adjustment, significant associations were found between moderate to severe psoriasis and obesity, T2DM and nonalcoholic fatty liver disease (NAFLD) compared with mild psoriasis.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions</jats:title> <jats:p>We report a large study of comorbidities, including depression, dyslipidaemia, T2DM and NAFLD, in people with psoriasis in Chile. The prevalence of comorbidities with psoriasis in Chile appears similar to that found in Western countries, and emphasizes the importance of assessing patients with psoriasis for risk factors for and presence of, comorbid disease in a multidisciplinary setting.</jats:p> </jats:sec>
      1Scopus© Citations 11
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    International eDelphi Study to Reach Consensus on the Methotrexate Dosing Regimen in Patients With Psoriasis
    (2022)
    Astrid M. van Huizen
    ;
    Stef P. Menting
    ;
    Rolland Gyulai
    ;
    Lars Iversen
    ;
    Gayle E. van der Kraaij
      40Scopus© Citations 19