Universidad del Desarrollo

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Increased Intrahepatic Mast Cell Density in Liver Cirrhosis Due to MASLD and Other Non-Infectious Chronic Liver Diseases
(MDPI AG, 2025-12-30)
Nicolás Ortiz-López
;
Araceli Pinto-León
;
Javiera Favi
;
Dannette Guíñez Francois
;
Larissa Aleman
Metabolic dysfunction-associated steatotic liver disease (MASLD) has become highly prevalent worldwide, and its pathogenesis and progression mechanisms remain incompletely understood. An increased activation of innate immune cells in the liver contributes to hepatic fibrogenesis via a chronic loop of inflammation and regeneration processes. Among them are mast cells (MCs), whose role in hepatic cirrhosis secondary to MASLD remains poorly studied. Our aim was to evaluate differences in MC density in cirrhotic liver tissue among patients with MASLD and other chronic liver disease etiologies. For this, a retrospective study of MC count was performed in cirrhotic liver explants obtained from MASLD, alcohol-related liver disease (ALD), and autoimmune hepatitis (AIH). We included a control group of subjects without liver damage. Tryptase-positive MCs were identified by indirect immunofluorescence and quantified as MC density per low-power field (MC/LPF). Group differences were analyzed using the Kruskal–Wallis test with Dunn’s multiple comparisons, considering p < 0.05 as statistically significant. A significantly higher MC density was observed in MASLD, ALD, and AIH patients compared with the control group. The group analysis showed that ALD patients exhibited higher MC density than AIH, with no observed difference between ALD and MASLD. MC density was correlated positively with tobacco smoking and alcohol use in the full analyzed group, suggesting them as risk factors of high MC liver infiltration. We conclude that MC density is augmented in MASLD-related cirrhosis, highlighting potential links between lifestyle factors and MC-mediated hepatic inflammation. Future studies should explore the mechanisms driving this association and evaluate whether targeting MCs could help mitigate fibrosis progression.</jats:p>
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Alcohol Absorption Modification After a Laparoscopic Sleeve Gastrectomy Due to Obesity
(2010)
Fernando Maluenda
;
Attila Csendes
;
Xabier De Aretxabala
;
Jaime Poniachik
;
Karen Salvo
Scopus© Citations 86
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Recurrence of hepatocellular carcinoma after liver transplantation: Prognostic and predictive factors of survival in a Latin American cohort
(2020)
Claudia Maccali
;
Aline L. Chagas
;
Ilka Boin
;
Emilio Quiñonez
;
Sebastián Marciano
13Scopus© Citations 18
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Liver transplantation for hepatocellular carcinoma: impact of expansion criteria in a multicenter cohort study from a high waitlist mortality region
(2021)
Federico Piñero
;
Margarita Anders
;
Ilka F. Boin
;
Aline Chagas
;
Emilio Quiñonez
Scopus© Citations 3 2
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Performance of pre‐transplant criteria in prediction of hepatocellular carcinoma progression and waitlist dropout
(2022)
Federico Piñero
;
Marcos Thompson
;
Ilka Boin
;
Aline Chagas
;
Emilio Quiñonez
2Scopus© Citations 3
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Direct‐Acting Antivirals and Hepatocellular Carcinoma: No Evidence of Higher Wait‐List Progression or Posttransplant Recurrence
(2020)
Federico Piñero
;
Ilka Boin
;
Aline Chagas
;
Emilio Quiñonez
;
Sebastián Marciano
7Scopus© Citations 15
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Resumen ejecutivo: Enfermedad por hígado graso no alcohólico en sujetos con diabetes mellitus tipo 2: Postura conjunta de la Asociación Chilena de Hepatología (ACHHEP) y la Sociedad Chilena de Diabetología (SOCHIDIAB)
(2021)
Juan Pablo Arab
;
Lorena Castro
;
Patricia C. Gómez
;
Paulina Vignolo
;
Marco Arrese
Scopus© Citations 1 7
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Liver transplantation for hepatocellular carcinoma: Evaluation of the alpha-fetoprotein model in a multicenter cohort from Latin America
(2016)
Federico Piñero
;
Matías Tisi Baña
;
Elaine Cristina de Ataide
;
Sergio Hoyos Duque
;
Sebastian Marciano
22Scopus© Citations 79
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A changing etiologic scenario in liver transplantation for hepatocellular carcinoma in a multicenter cohort study from Latin America
(2018)
Federico Piñero
;
Paulo Costa
;
Yuri Longatto Boteon
;
Sergio Hoyos Duque
;
Sebastian Marciano
11Scopus© Citations 25
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Results of liver transplantation for hepatocellular carcinoma in a multicenter latin American cohort study
(2018)
Federico Pinero
;
Paulo Costa
;
Yuri L. Boteon
;
Sergio Hoyos Duque
;
Sebastian Marciano
Scopus© Citations 11 3

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