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90 Role of microrna-145 in epithelial ovarian cancer
(2020)
Carmen Romero
;
Maritza P Garrido
;
Ignacio Torres
;
Andrea Hernandez
;
Jonas Chnaiderman
3
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CAUSES OF CONTRACTUAL DISPUTES IN CONSTRUCTION PROJECTS
(2023)
SERPELL-BLEY, ALFREDO FEDERICO
;
Ignacio Torres
;
Aslihan Karatas
;
Amir Iranmanesh
;
Asli Pelin Gurgun
<jats:p>This article reports on the main causes of contractual disputes in Chilean construction projects, a subject not much studied in the country. The research included an extensive review of international literature looking for the main causes of contractual disputes in construction as a reference and framework. Then, a detailed study of 98 dispute arbitrations processes of construction projects was carried out in search of the main causes of disputes. It was found that the main causes of contractual disputes were those related to the category of design and information and that the most frequent cause in general was non-payment or delay in payment. This result is consistent with causes of contractual disputes as reported in international literature. From the 98 arbitrations studied it was possible to establish that the duration of an arbitration was 531 days on average, but that this depends on the cause of termination of the arbitration. It was also observed that the amount requested from the arbitrator by the plaintiff was 80% of the original amount of the contract on average and that the compensation after the sentence was 28% on average of what was initially requested. This information might be useful for companies that anticipate carrying out construction works in Chile and in Latin-American countries to reduce the potential for claims in their works.</jats:p>
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NGF/TRKA Decrease miR-145-5p Levels in Epithelial Ovarian Cancer Cells
(2020)
Maritza P. Garrido
;
Ignacio Torres
;
Alba Avila
;
Jonás Chnaiderman
;
Manuel Valenzuela-Valderrama
<jats:p>Nerve Growth Factor (NGF) and its high-affinity receptor tropomyosin receptor kinase A (TRKA) increase their expression during the progression of epithelial ovarian cancer (EOC), promoting cell proliferation and angiogenesis through several oncogenic proteins, such as c-MYC and vascular endothelial growth factor (VEGF). The expression of these proteins is controlled by microRNAs (miRs), such as miR-145, whose dysregulation has been related to cancer. The aims of this work were to evaluate in EOC cells whether NGF/TRKA decreases miR-145 levels, and the effect of miR-145 upregulation. The levels of miR-145-5p were assessed by qPCR in ovarian biopsies and ovarian cell lines (human ovarian surface epithelial cells (HOSE), A2780 and SKOV3) stimulated with NGF. Overexpression of miR-145 in ovarian cells was used to evaluate cell proliferation, migration, invasion, c-MYC and VEGF protein levels, as well as tumor formation and metastasis in vivo. In EOC samples, miR-145-5p levels were lower than in epithelial ovarian tumors. Overexpression of miR-145 decreased cell proliferation, migration and invasion of EOC cells, changes that were concomitant with the decrease in c-MYC and VEGF protein levels. We observed decreased tumor formation and suppressed metastasis behavior in mice injected with EOC cells that overexpressed miR-145. As expected, ovarian cell lines stimulated with NGF diminished miR-145-5p transcription and abundance. These results suggest that the tumoral effects of NGF/TRKA depend on the regulation of miR-145-5p levels in EOC cells, and that its upregulation could be used as a possible therapeutic strategy for EOC.</jats:p>
Scopus© Citations 27 3

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